Systematic Review and Meta-Analysis of Randomized Controlled Trials of Xingnaojing Treatment for Stroke

Table 1

Characteristics of the included studies.

Study	Number of patients	Follow-up (days)	Baseline comparison	Adverse event	Outcomes measure; (primary/secondary)	Treatment group dosage	Types of stroke
Cai et al. 2000 [29]	256	14	Y	N	TER, CSS	XNJ 30–60 mL/d + CWM	IS
Chen et al. 2004a [30]	100	14	Y	N	TER	XNJ 20 mL/d + CWM	IS
Chen et al. 2004b [31]	70	14	Y	N	TNF-𝛼, IL-6, IL-1, ESSS	XNJ 40 mL/d + CWM	ICH
Chen 2013 [32]	202	21	Y	Y	NIHSS, IL-9	XNJ 30 mL/d + CWM	ICH
Lei 2013 [33]	120	28	Y	Y	TER	XNJ 20 mL/d + CWM	ICH
Li 2011 [34]	118	14	Y	N	TNF-𝛼, IL-6, NIHSS	XNJ 40 mL/d + CWM	ICH
Liu and Bai 2004 [35]	70	14	Y	N	TNF-𝛼, IL-6, IL-8, ESSS	XNJ 40 mL/d + CWM	ICH/IS
Ming et al. 2010 [36]	91	21	Y	N	ESS,	XNJ 20 mL/d + CWM	ICH
Wang 2013 [37]	155	14	Y	N	TER	XNJ 20 mL/d + CWM	ICH/IS/SAH
Wei and Li 2009 [13]	120	28	Y	Y	TER, CSS	XNJ 10 mL/d + CWM	ICH
Zhang et al. 2012 [38]	65	14	Y	N	NIHSS	XNJ 20 mL/d + CWM	IS
Zhang et al. 2013 [39]	63	14	Y	N	NIHSS	XNJ 20 mL/d + CWM	IS
Zhou et al. 2005 [40]	84	28	Y	N	TER	XNJ 20 mL/d + CWM	ICH

Note. XNJ is Xingnaojing injection; CWM is conventional western medicine; TER is total effective rate; SR is soberness rat; NIHSS is the National Institute of Health stroke scale; SSS is Scandinavian Stroke Scale; ESS is the European stroke scale; ESSS is Edinburgh-Scandinavia stroke scale; CSS is the Chinese stroke scale; IS is ischemic stroke; ICH is intracerebral hemorrhage; SAH is subarachnoid hemorrhage. The column of “Baseline comparison” shows that the study did (Y) or did not (N) report the baseline comparison between the treatment and control groups.