Persea declinata (Bl.) Kosterm Bark Crude Extract Induces Apoptosis in MCF-7 Cells via G0/G1 Cell Cycle Arrest, Bcl-2/Bax/Bcl-xl Signaling Pathways, and ROS Generation
Figure 4
Effect of PDM on ROS production. (a) Representative images of MCF-7 cells treated with DMEM, doxorubicin, or PDM for 24 h and stained with DHE dye. PDM induced a noteworthy elevation in nuclear ROS in the PDM-treated MCF-7 cells (magnification: 200x). (b) Representative bar charts indicating dose-dependent increased ROS in the nucleus of the PDM-treated MCF-7 cells.