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Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 280120, 11 pages
http://dx.doi.org/10.1155/2014/280120
Research Article

Antitumor Activity of Chinese Propolis in Human Breast Cancer MCF-7 and MDA-MB-231 Cells

1School of Life Science, Liaocheng University, Liaocheng 252059, China
2School of Life Science, Anhui University, Hefei 230039, China
3College of Animal Sciences, Zhejiang University, Hangzhou 310029, China

Received 10 February 2014; Revised 10 April 2014; Accepted 13 April 2014; Published 22 May 2014

Academic Editor: Thomas Efferth

Copyright © 2014 Hongzhuan Xuan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [40 citations]

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  • Karina Bettega Felipe, Maicon Roberto Kviecinski, Fabiana Ourique da Silva, Nádia Falcão Bücker, Mirelle Sinfroni Farias, Luiza Sheyla Evenni Porfirio Will Castro, Valdelúcia Maria Alves de Souza Grinevicius, Nadia Sandrini Motta, João Francisco Gomes Correia, Maria Helena Rossi, and Rozangela Curi Pedrosa, “Inhibition of tumor proliferation associated with cell cycle arrest caused by extract and fraction from Casearia sylvestris (Salicaceae),” Journal of Ethnopharmacology, 2014. View at Publisher · View at Google Scholar
  • Ricardo Silva-Carvalho, Vera Miranda-Gonçalves, Ana Margarida Ferreira, Susana M. Cardoso, Abílio J.F.N. Sobral, Cristina Almeida-Aguiar, and Fátima Baltazar, “Antitumoural and antiangiogenic activity of Portuguese propolis in in vitro and in vivo models,” Journal of Functional Foods, vol. 11, pp. 160–171, 2014. View at Publisher · View at Google Scholar
  • Omer Abdalla Ahmed Hamdi, Syarifah Nur Syed Abdul Rahman, Khalijah Awang, Norhanom Abdul Wahab, Chung Yeng Looi, Noel Francis Thomas, and Sri Nurestri Abd Malek, “ Cytotoxic Constituents from the Rhizomes of Curcuma zedoaria ,” The Scientific World Journal, vol. 2014, pp. 1–11, 2014. View at Publisher · View at Google Scholar
  • Eduardo Morgado Schmidt, Daniele Stock, Fabio José Garcia Chada, Daiane Finger, Alexandra Christine Helena Frankland Sawaya, Marcos Nogueira Eberlin, Maria Lurdes Felsner, Sueli Pércio Quináia, Marta Chagas Monteiro, and Yohandra Reyes Torres, “A Comparison between Characterization and Biological Properties of Brazilian Fresh and Aged Propolis,” BioMed Research International, vol. 2014, pp. 1–10, 2014. View at Publisher · View at Google Scholar
  • Simona Martinotti, and Elia Ranzato, “Propolis: a new frontier for wound healing?,” Burns & Trauma, vol. 3, no. 1, 2015. View at Publisher · View at Google Scholar
  • Aglaé Trejo-Vargas, Elisa Hernández-Mercado, Rosa María Ordóñez-Razo, Roberto Lazzarini, Diego Julio Arenas-Aranda, María Concepción Gutiérrez-Ruiz, Mina Königsberg, and Armando Luna-López, “Bik subcellular localization in response to oxidative stress induced by chemotherapy, in Two different breast cancer cell lines and a Non-tumorigenic epithelial cell line,” Journal of Applied Toxicology, 2015. View at Publisher · View at Google Scholar
  • Anna Rzepecka-Stojko, Agata Kabala-Dzik, Aleksandra Mozdzierz, Robert Kubina, Robert D. Wojtyczka, Rafal Stojko, Arkadiusz Dziedzic, Zaneta Jastrzebska-Stojko, Magdalena Jurzak, Ewa Buszman, and Jerzy Stojko, “Caffeic Acid Phenethyl Ester and Ethanol Extract of Propolis Induce the Complementary Cytotoxic Effect on Triple-Negative Breast Cancer Cell Lines,” Molecules, vol. 20, no. 5, pp. 9242–9262, 2015. View at Publisher · View at Google Scholar
  • Ahmet Mentese, Ahmet Alver, Aysegul Sumer, and Selim Demir, “Effects of homocysteine on adipocyte differentiation and CD36 gene expression in 3T3-L1 adipocytes,” Journal of Cell Communication and Signaling, 2015. View at Publisher · View at Google Scholar
  • Daichi Kudo, Masatoshi Inden, Shin-ichiro Sekine, Naritaka Tamaoki, Kazuki Iida, Eiji Naito, Kazuhiro Watanabe, Hiroaki Kamishina, Toshiyuki Shibata, and Hozumi Isao, “Conditioned medium of dental pulp cells stimulated by Chinese propolis show neuroprotection and neurite extension in vitro,” Neuroscience Letters, 2015. View at Publisher · View at Google Scholar
  • Rabia Onbas, Aslihan Kazan, Ayse Nalbantsoy, and Ozlem Yesil-Celiktas, “Cytotoxic and Nitric Oxide Inhibition Activities of Propolis Extract along with Microencapsulation by Complex Coacervation,” Plant Foods for Human Nutrition, 2016. View at Publisher · View at Google Scholar
  • Ibrahim Turan, Selim Demir, Kagan Kilinc, Nesibe Arslan Burnaz, Serap Ozer Yaman, Kubra Akbulut, Ahmet Mentese, Yuksel Aliyazicioglu, and Orhan Deger, “Antiproliferative and Apoptotic Effect of Morus nigra Extract on Human Prostate Cancer Cells,” Saudi Pharmaceutical Journal, 2016. View at Publisher · View at Google Scholar
  • Ekrem Darendelioglu, Gurkan Aykutoglu, Musa Tartik, and Giyasettin Baydas, “Turkish propolis protects human endothelial cells in vitro from homocysteine-induced apoptosis,” Acta Histochemica, 2016. View at Publisher · View at Google Scholar
  • ShuYan Liu, ZhaoYang Wang, and JunYing Miao, “Potential roles of annexin A7 GTPase in autophagy, senescence and apoptosis,” RSC Adv., vol. 6, no. 115, pp. 114587–114592, 2016. View at Publisher · View at Google Scholar
  • Selim Demir, Yuksel Aliyazicioglu, Ibrahim Turan, Sema Misir, Ahmet Mentese, Serap Ozer Yaman, Kubra Akbulut, Kagan Kilinc, and Orhan Deger, “Antiproliferative and proapoptotic activity of Turkish propolis on human lung cancer cell line,” Nutrition And Cancer-An International Journal, vol. 68, no. 1, pp. 165–172, 2016. View at Publisher · View at Google Scholar
  • Hongzhuan Xuan, Yuehua Wang, Aifeng Li, Chongluo Fu, Yuanjun Wang, and Wenjun Peng, “Bioactive Components of Chinese Propolis Water Extract on Antitumor Activity and Quality Control,” Evidence-Based Complementary and Alternative Medicine, vol. 2016, pp. 1–9, 2016. View at Publisher · View at Google Scholar
  • Huasong Chang, Yuehua Wang, Xusheng Yin, Xinying Liu, and Hongzhuan Xuan, “Ethanol extract of propolis and its constituent caffeic acid phenethyl ester inhibit breast cancer cells proliferation in inflammatory microenvironment by inhibiting TLR4 signal pathway and inducing apoptosis and autophagy,” BMC Complementary and Alternative Medicine, vol. 17, no. 1, 2017. View at Publisher · View at Google Scholar
  • Tomoyuki Ueda, Masatoshi Inden, Katsuhiro Shirai, Shin-ichiro Sekine, Yuji Masaki, Hisaka Kurita, Kenji Ichihara, Takashi Inuzuka, and Isao Hozumi, “The effects of Brazilian green propolis that contains flavonols against mutant copper-zinc superoxide dismutase-mediated toxicity,” Scientific Reports, vol. 7, no. 1, 2017. View at Publisher · View at Google Scholar
  • Aruna Priyadharshni Subramanian, Agnes Aruna John, Muthu Vignesh Vellayappan, Arunpandian Balaji, Saravana Kumar Jaganathan, Manikandan, and Eko Supriyanto, “An insight into the putative role of victuals like honey and its polyphenols in breast cancer,” Current Science, vol. 112, no. 9, pp. 1839–1854, 2017. View at Publisher · View at Google Scholar
  • Júlia Cisilotto, Louis P. Sandjo, Larissa G. Faqueti, Heloísa Fernandes, Débora Joppi, Maique W. Biavatti, and Tânia Beatriz Creczynski-Pasa, “Cytotoxicity mechanisms in melanoma cells and UPLC-QTOF/MS 2 chemical characterization of two Brazilian stingless bee propolis: the uncommon presence of piperidinic alkaloids,” Journal of Pharmaceutical and Biomedical Analysis, 2017. View at Publisher · View at Google Scholar
  • Agata Kabała-Dzik, Anna Rzepecka-Stojko, Robert Kubina, Żaneta Jastrzębska-Stojko, Rafał Stojko, Robert Wojtyczka, and Jerzy Stojko, “Migration Rate Inhibition of Breast Cancer Cells Treated by Caffeic Acid and Caffeic Acid Phenethyl Ester: An In Vitro Comparison Study,” Nutrients, vol. 9, no. 10, pp. 1144, 2017. View at Publisher · View at Google Scholar
  • Visweswara Rao Pasupuleti, Lakhsmi Sammugam, Nagesvari Ramesh, and Siew Hua Gan, “Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits,” Oxidative Medicine and Cellular Longevity, vol. 2017, pp. 1–21, 2017. View at Publisher · View at Google Scholar
  • Tugba Ozdal, Gulce Sari-Kaplan, Ergul Mutlu-Altundag, Dilek Boyacioglu, and Esra Capanoglu, “Evaluation of Turkish propolis for its chemical composition, antioxidant capacity, anti-proliferative effect on several human breast cancer cell lines and proliferative effect on fibroblasts and mouse mesenchymal stem cell line,” Journal of Apicultural Research, pp. 1–12, 2018. View at Publisher · View at Google Scholar
  • Yufei Zheng, Yuqi Wu, Xi Chen, Xiasen Jiang, Kai Wang, and Fuliang Hu, “Chinese Propolis Exerts Anti-Proliferation Effects in Human Melanoma Cells by Targeting NLRP1 Inflammatory Pathway, Inducing Apoptosis, Cell Cycle Arrest, and Autophagy,” Nutrients, vol. 10, no. 9, pp. 1170, 2018. View at Publisher · View at Google Scholar
  • Aris Rosidah, Eviana Norahmawati, Agustina Tri Endharti, Ihda Dian Kusuma, and Nurdiana, “Indonesian Pasuruan propolis extract does not exert anti-proliferation and pro-apoptotic effect on human colon carcinoma cell line HT-29,” Tropical Journal of Pharmaceutical Research, vol. 17, no. 7, pp. 1345–1351, 2018. View at Publisher · View at Google Scholar
  • Santi Phosri, Nisachon Jangpromma, Ghee T. Tan, Leng Chee Chang, Supakit Wongwiwatthananukit, Surachai Maijaroen, Preeyanan Anwised, Wisarut Payoungkiattikun, and Sompong Klaynongsruang, “Siamese crocodile white blood cell extract inhibits cell proliferation and promotes autophagy in multiple cancer cell lines,” Journal of Microbiology and Biotechnology, vol. 28, no. 6, pp. 1007–1021, 2018. View at Publisher · View at Google Scholar
  • Dan Liu, Pengtao You, Yan Luo, Min Yang, and Yanwen Liu, “Galangin Induces Apoptosis in MCF-7 Human Breast Cancer Cells Through Mitochondrial Pathway and Phosphatidylinositol 3-Kinase/Akt Inhibition,” Pharmacology, vol. 102, no. 1-2, pp. 58–66, 2018. View at Publisher · View at Google Scholar
  • Ahmad Oryan, Esmat Alemzadeh, and Ali Moshiri, “Potential role of propolis in wound healing: Biological properties and therapeutic activities,” Biomedicine & Pharmacotherapy, vol. 98, pp. 469–483, 2018. View at Publisher · View at Google Scholar
  • Mehmet Fatih Seyhan, Eren Yılmaz, Özlem Timirci-Kahraman, Neslihan Saygılı, Halil İbrahim Kısakesen, Sema Gazioğlu, Ahmet C. Gören, Allison Pınar Eronat, A. Begüm Ceviz, Tülin Öztürk, Hülya Yılmaz-Aydoğan, and Oğuz Öztürk, “Different propolis samples, phenolic content, and breast cancer cell lines: Variable cytotoxicity ranging from ineffective to potent,” IUBMB Life, 2018. View at Publisher · View at Google Scholar
  • Katarzyna Pobiega, Karolina Kraśniewska, and Małgorzata Gniewosz, “Application of propolis in antimicrobial and antioxidative protection of food quality – A review,” Trends in Food Science & Technology, 2018. View at Publisher · View at Google Scholar
  • Tuan Nadrah Naim Tuan Ismail, Kannan Thirumulu Ponnuraj, Siti Amrah Sulaiman, Norul Badriah Hassan, and Che Nin Man, “Chemical constituents of Malaysian apis mellifera propolis,” Sains Malaysiana, vol. 47, no. 1, pp. 117–122, 2018. View at Publisher · View at Google Scholar
  • Virgilio D. Ebajo, Mariquit M. De Los Reyes, Glenn G. Oyong, Consolacion Y. Ragasa, and Chien-Chang Shen, “Cytotoxic prenylflavanones from philippine stingless bee (Tetragonula biroi Friese) nests,” Asian Journal of Chemistry, vol. 30, no. 3, pp. 613–619, 2018. View at Publisher · View at Google Scholar
  • Hassiba Rouibah, Bachaer Aburmeleih, Hemzeh El-Amir, Wided Kebsa, Mesbah Lahouel, Malek Zihlif, Mamoun Ahram, and Ebtihal Mustafa, “Algerian propolis potentiates doxorubicin mediated anticancer effect against human pancreatic panc-1 cancer cell line through cell cycle arrest, apoptosis induction and p-glycoprotein inhibition,” Anti-Cancer Agents in Medicinal Chemistry, vol. 18, no. 3, pp. 375–387, 2018. View at Publisher · View at Google Scholar
  • Watanabe, and Sforcin, “Effects of propolis and caffeic acid phenethyl ester (Cape) on breast cancer cells,” Current Pharmacogenomics and Personalized Medicine, vol. 16, no. 2, pp. 88–93, 2018. View at Publisher · View at Google Scholar
  • Tomoyuki Ueda, Taisei Ito, Hisaka Kurita, Masatoshi Inden, and Isao Hozumi, “p-Coumaric Acid Has Protective Effects against Mutant Copper–Zinc Superoxide Dismutase 1 via the Activation of Autophagy in N2a Cells,” International Journal of Molecular Sciences, vol. 20, no. 12, pp. 2942, 2019. View at Publisher · View at Google Scholar
  • Başak Aru, Etil Güzelmeric, Aslı Akgül, Gülderen Yanıkkaya Demirel, and Hasan Kırmızıbekmez, “Antiproliferative Activity of Chemically Characterized Propolis from Turkey and Its Mechanisms of Action,” Chemistry & Biodiversity, vol. 16, no. 7, 2019. View at Publisher · View at Google Scholar
  • Vedrana Radovanović, Josipa Vlainić, Nikolina Hanžić, Petra Ukić, Nada Oršolić, Goran Baranović, and Maja Jazvinšćak Jembrek, “Neurotoxic Effect of Ethanolic Extract of Propolis in the Presence of Copper Ions is Mediated through Enhanced Production of ROS and Stimulation of Caspase-3/7 Activity,” Toxins, vol. 11, no. 5, pp. 273, 2019. View at Publisher · View at Google Scholar
  • Mehrnoosh Zakerkish, Maryam Jenabi, Narjes Zaeemzadeh, Ali Asghar Hemmati, and Niloofar Neisi, “The Effect of Iranian Propolis on Glucose Metabolism, Lipid Profile, Insulin Resistance, Renal Function and Inflammatory Biomarkers in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind Clinical Trial,” Scientific Reports, vol. 9, no. 1, 2019. View at Publisher · View at Google Scholar
  • Simona Martinotti, Giorgia Pellavio, Umberto Laforenza, and Elia Ranzato, “Propolis Induces AQP3 Expression: A Possible Way of Action in Wound Healing,” Molecules, vol. 24, no. 8, pp. 1544, 2019. View at Publisher · View at Google Scholar
  • Uma Devi, Manjari Singh, Subhadeep Roy, Pushpraj S. Gupta, Mohd. Nazam Ansari, Abdulaziz S. Saeedan, and Gaurav Kaithwas, “Activation of prolyl hydroxylase‐2 for stabilization of mitochondrial stress along with simultaneous downregulation of HIF‐1α/FASN in ER + breast cancer subtype,” Cell Biochemistry and Function, 2019. View at Publisher · View at Google Scholar
  • Yi-zhen Shi, Yi-chen Liu, Yu-fei Zheng, Yi-fan Chen, Juan-juan Si, Min-li Chen, Qi-yang Shou, Huo-qing Zheng, and Fu-liang Hu, “Ethanol Extract of Chinese Propolis Attenuates Early Diabetic Retinopathy by Protecting the Blood-Retinal Barrier in Streptozotocin-Induced Diabetic Rats,” Journal of Food Science, 2019. View at Publisher · View at Google Scholar