Differential Effects of Naja naja atra Venom on Immune Activity

Table 1

NNAV had no effect on body weight, lymphoid organ index, or T lymphocyte subpopulations in normal mice.

	Control	20 𝜇g/kg	40 𝜇g/kg	80 𝜇g/kg
Body weight	34.41 ± 1.95	35.24 ± 2.19	33.07 ± 2.51	35.61 ± 1.15
Spleen index	38.17 ± 3.21	44.17 ± 4.18	40.55 ± 9.02	38.17 ± 6.58
Thymus index	9.83 ± 2.46	11.65 ± 2.95	11.52 ± 3.93	9.99 ± 3.96
CD4-T %	25.00 ± 1.99	23.59 ± 6.25	26.06 ± 3.47	25.86 ± 4.10
CD8-T %	8.46 ± 2.33	7.74 ± 1.38	7.82 ± 1.37	7.51 ± 1.89
CD4-T/CD8-T	3.09 ± 0.60	3.31 ± 0.33	3.27 ± 0.55	3.36 ± 0.44

After 21 days orally given NNAV or water, all ICR mice were sacrificed; spleen and thymus of each mouse were collected and weighted immediately. The T-lymphocyte subpopulations in spleen were measured by flow cytometer by gating on CD3⁺CD4⁺ (CD4-T) or CD3⁺CD8⁺ (CD8-T) cell population. The data present means ± SD; 𝑛=8.