Review Article

Effectiveness, Medication Patterns, and Adverse Events of Traditional Chinese Herbal Patches for Osteoarthritis: A Systematic Review

Table 3

Effect estimates of TCHPs compared with diclofenac ointment or placebo for OA.

First author (year)Effect estimate (95% CI)Comparisons

Local pain relief
Liu, 2004 [28]#MD −1.14 (−3.56, 1.28)Self-prescribed herbal patch versus diclofenac ointment
Wang, 2010 [21]MD 0.00 (−1.09, 1.09)Huo Xue Hua Yu patch versus diclofenac ointment
Wang, 2012 [4]*MD −1.44 (−1.69, −1.19)Fu Fang Nan Xing Zhi Tong patch versus placebo
Wang, 2012 [4]*MD 1.08 (0.83, 1.33)Shang Shi Zhi Tong patch versus placebo
Zheng, 2006 [23]RR 0.50 (0.10, 2.56)Qing Peng patch versus diclofenac ointment

Function of knee OA
Liu, 2004 [28]#MD −1.30 (−6.46, 3.86)Self-prescribed herbal patch versus diclofenac ointment (function)
Wang, 2010 [21]MD 0.06 (−0.29, 0.41)Huo Xue Hua Yu patch versus diclofenac ointment (ROM)
Wang, 2010 [21]MD 0.06 (−0.40, 0.52)Huo Xue Hua Yu patch versus diclofenac ointment (flexion deformity)
Wang, 2012 [4]*MD −0.42 (−0.47, −0.37)Fu Fang Nan Xing Zhi Tong patch versus placebo (stiffness)
Wang, 2012 [4]*MD −0.37 (−0.42, −0.32)Shang Shi Zhi Tong patch versus placebo (stiffness)
Wang, 2012 [4]*MD −2.61 (−3.01, −2.21)Fu Fang Nan Xing Zhi Tong patch versus placebo (physical function)
Wang, 2012 [4]*MD −2.97 (−3.38, −2.56)Shang Shi Zhi Tong patch versus placebo (physical function)

Global effectiveness rate
Lin, 2006 [25]#RR 0.67 (0.13, 3.53)Shang Ke Xiao Yan versus diclofenac
Long, 2006 [26]#RR 1.87 (0.50, 7.01)Shang Ke Hei Yao patch versus diclofenac ointment
Guan, 2010 [22]RR 0.43 (0.12, 1.51)Zhuang Gu Tong Bi patch versus diclofenac ointment
Zheng, 2006 [23]RR 0.25 (0.03, 2.13)Qing Peng patch versus diclofenac ointment
Zhang, 2008 [20]RR 0.43 (0.14, 1.26)Zhi Tong Tou Gu patch versus diclofenac ointment
Wang, 2006 [58]RR 0.22 (0.05, 0.97)Xiao Tong patch versus diclofenac ointment

Data was synthesized using MD with 95% CI for continuous outcomes or RR with 95% CI for binary outcomes; *there was no statistically significant difference between the intervention and control group in score reduction or global effectiveness rate ( ); #noninferiority results.