First author (year) Intervention group Control group Patches Incidence AEs Patches Incidence AEs
Cao*, 2002 [84 ] Qu Tong 11.49% (10/87) Skin allergy Gu Tong Not stated Not stated Du, 1997 [53 ] Ji Li Huo Xue 10.00% (6/60) Erythema after 4-5 days; itching in the location of patch Dong Fang Huo Xue Not stated Not stated Guo, 2008 [36 ] Xiong Zhi Tong Xiao 0.66% (1/152) Itching Tong Luo Qu Yu 2% (1/50) Itching Hao, 1999 [70 ] Feng Shi Shang Tong 6.67% (4/60) Contact dermatitis and exit, itchy skin NA NA NA Hao, 1999 [64 ] Fu Fang Ling Zhi 6.67% (4/60) Contact dermatitis and exit, itching after 48 hours NA NA NA Li, 2009 [66 ] Yao Tong Ning 2.08% (1/48) Terminated with locally severe blister NA NA NA Li, 2009
[71 ] Ba Wei No data Local discomfort, burning sensation, itching, or rash Shang Shi Zhi Tong No data Local discomfort, burning sensation, itching, or rash Li, 2005 [67 ] Mei Pu Zheng Gu No data Rash, blister, and itching NA NA NA Lin, 2006 [25 ] Shang Ke Xiao Yan No data No significant allergic reaction Diclofenac sodium tablets No data Not stated Liu, 2011 [72 ] Xiao Tong 8.89% (4/45) Rash, burning sensation, and itching Gu Tong 6.67% (3/45) Rash Liu, 2008 [49 ] Hei Hu No data Redness, oozing, purulent or itching, and rash Qian Shan Huo Xue Few people Local itching Ren, 1998 [68 ] Gu Ci Ting No data Skin redness and blister NA NA NA Su, 2010 [73 ] Jie Gu 6.41% (5/78) Gastrointestinal discomfort, unsatisfied Glucosamine sulfate 5.71% (4/70) Gastrointestinal discomfort, unsatisfied Tao, 2005 [69 ] Xiao Zhong Zhi Tong No data Skin redness, itching, and blister NA NA NA Wang, 2002 [85 ] Fu Fang Yan Tong Ning 1.00% (2/200) Rash and itching Gou Pi 4.00% (4/100) Rash and itching Wang, 2012 [4 ] Fu Fang Nan Xing and Shang Shi Jie Tong 7.50% (9/120) Rash, itching, and erythema; contact dermatitis Placebo 0.00% (0/30) None Wang, 2008 [57 ] Feng Shi Gu Tong 2.00% (2/100) Rash Gou Pi 4.44% (4/90) Allergic reactions Xu, 2000 [48 ] Fu Fang San Sheng 2.64% (2/76) Itchy skin after 48 hours Zhuang Gu Guan Jie pill 0.00% (0/20) None Yang, 1999 [30 ] Gu Zheng Sheng Zheng 4.00% (2/50) Rash Gu Yong Ling liniment 8.00% (2/25) Mild rash, flushing
Wu, 2005 [41 ] Blistering therapy 50.00% (15/30) Pain and itching rash He Luo Zhi Tong 6.67% (2/30) Allergic reactions Zeng, 2010 [74 ] Tong Yu 8.00% (2/25) Mild stomach discomfort and mild nausea in the beginning Xiao Tong Not stated Not stated Zhang, 2008 [20 ] Zhi Tong Tou Gu 12.24% (6/49) Skin rash, erythema, and so forth. Diclofenac ointment 24.00% (6/25) Skin rash, erythema, and so forth. Zhang, 2005 [35 ] She Xiang Tong Bi Ba Bu 5.22% (6/115) Rash and itching Tong Luo Qu Gu
7.96% (9/113) Itching, flushing, swelling, and so forth.
Pan, 2008 [32 ] Gu Tong Ning 5.65% (19/336) Redness and itching Gu Tong 8.93% (10/112) Redness and itching
Zhang, 2011 [86 ] Qu Yu Zhi Tong No data Few AEs Sodium hyaluronate Not stated Not stated
Zhou, 2003 [87 ] Wei Ling Xian Few patients Blistering NA NA NA