Review Article

Effectiveness, Medication Patterns, and Adverse Events of Traditional Chinese Herbal Patches for Osteoarthritis: A Systematic Review

Table 7

Detailed AEs of TCHPs for OA after 3-4-week follow-ups.

First author (year)Intervention groupControl group
PatchesIncidenceAEsPatchesIncidenceAEs

Cao*, 2002 [84]Qu Tong11.49% (10/87)Skin allergyGu TongNot statedNot stated

Du, 1997 [53]Ji Li Huo Xue 10.00% (6/60)Erythema after 4-5 days; itching in the location of patchDong Fang Huo XueNot statedNot stated

Guo, 2008 [36]Xiong Zhi Tong Xiao 0.66% (1/152)ItchingTong Luo Qu Yu2% (1/50)Itching

Hao, 1999 [70]Feng Shi Shang Tong 6.67% (4/60)Contact dermatitis and exit, itchy skinNANANA

Hao, 1999 [64]Fu Fang Ling Zhi 6.67% (4/60)Contact dermatitis and exit, itching after 48 hoursNANANA

Li, 2009 [66]Yao Tong Ning 2.08% (1/48)Terminated with locally severe blister NANANA

Li, 2009 [71] Ba Wei No dataLocal discomfort, burning sensation, itching, or rashShang Shi Zhi TongNo dataLocal discomfort, burning sensation, itching, or rash

Li, 2005 [67]Mei Pu Zheng Gu No dataRash, blister, and itchingNANANA

Lin, 2006 [25]Shang Ke Xiao Yan No data No significant allergic reactionDiclofenac sodium tabletsNo dataNot stated

Liu, 2011 [72]Xiao Tong 8.89% (4/45)Rash, burning sensation, and itchingGu Tong6.67% (3/45)Rash

Liu, 2008 [49]Hei Hu No dataRedness, oozing, purulent or itching, and rashQian Shan Huo Xue Few peopleLocal itching

Ren, 1998 [68]Gu Ci Ting No dataSkin redness and blisterNANANA

Su, 2010 [73]Jie Gu 6.41% (5/78)Gastrointestinal discomfort, unsatisfied Glucosamine sulfate5.71% (4/70)Gastrointestinal discomfort, unsatisfied

Tao, 2005 [69] Xiao Zhong Zhi Tong No dataSkin redness, itching, and blisterNANANA

Wang, 2002 [85]Fu Fang Yan Tong Ning1.00% (2/200)Rash and itchingGou Pi4.00% (4/100)Rash and itching

Wang, 2012 [4]Fu Fang Nan Xing and Shang Shi Jie Tong 7.50% (9/120) Rash, itching, and erythema; contact dermatitisPlacebo0.00% (0/30)None

Wang, 2008 [57]Feng Shi Gu Tong 2.00% (2/100)RashGou Pi4.44% (4/90)Allergic reactions

Xu, 2000 [48]Fu Fang San Sheng 2.64% (2/76)Itchy skin after 48 hoursZhuang Gu Guan Jie pill 0.00% (0/20)None

Yang, 1999 [30]Gu Zheng Sheng Zheng 4.00% (2/50)RashGu Yong Ling liniment 8.00% (2/25)Mild rash, flushing

Wu, 2005 [41] Blistering therapy50.00% (15/30) Pain and itching rashHe Luo Zhi Tong 6.67% (2/30)Allergic reactions

Zeng, 2010 [74]Tong Yu 8.00% (2/25)Mild stomach discomfort and mild nausea in the beginningXiao TongNot statedNot stated

Zhang, 2008 [20]Zhi Tong Tou Gu 12.24% (6/49)Skin rash, erythema, and so forth.Diclofenac ointment24.00% (6/25)Skin rash, erythema, and so forth.

Zhang, 2005 [35]She Xiang Tong Bi Ba Bu 5.22% (6/115)Rash and itching Tong Luo Qu Gu 7.96% (9/113)Itching, flushing, swelling, and so forth.

Pan, 2008 [32] Gu Tong Ning 5.65% (19/336)Redness and itchingGu Tong8.93% (10/112)Redness and itching

Zhang, 2011 [86]Qu Yu Zhi Tong No data Few AEs Sodium hyaluronateNot statedNot stated

Zhou, 2003 [87] Wei Ling XianFew patients BlisteringNANANA

Values are based on identified data. *No specific data reported for each AEs. Lower AEs in intervention group. #A special therapy mainly for blistering. NA: not applicable.