Subacute Oral Toxicity of Yukmijiwhang-Tang in Crl:CD Sprague-Dawley Rats and Its Cytotoxicity

Table 6

Absolute organ weights in rats treated with YMJ for 4 weeks.

Dose (mg/kg/day)	0	500	1000	2000
Male rats
Brain	1.919 ± 0.0808	1.880 ± 0.1136	1.949 ± 0.0403	1.945 ± 0.0833
Pituitary gland	0.010 ± 0.0026	0.010 ± 0.0023	0.010 ± 0.0022	0.009 ± 0.0028
Liver	10.102 ± 0.5764	10.403 ± 0.7475	10.483 ± 0.1410	10.234 ± 1.5110
Spleen	0.607 ± 0.0700	0.640 ± 0.0979	0.725 ± 0.0848	0.643 ± 0.1482
Heart	1.180 ± 0.0643	1.172 ± 0.1247	1.173 ± 0.0273	1.110 ± 0.1174
Thymus	0.558 ± 0.1072	0.600 ± 0.0548	0.492 ± 0.0949	0.550 ± 0.1330
Salivary glands	0.625 ± 0.0561	0.581 ± 0.0779	0.593 ± 0.0475	0.547 ± 0.0688
Seminal vesicle	1.031 ± 0.1515	1.089 ± 0.1220	0.944 ± 0.1084	0.994 ± 0.1193
Prostate	0.468 ± 0.1143	0.405 ± 0.1367	0.405 ± 0.0543	0.402 ± 0.0394
Kidneys	2.501 ± 0.1742	2.506 ± 0.1711	2.535 ± 0.0996	2.498 ± 0.2781
Adrenal glands	0.052 ± 0.0073	0.046 ± 0.0044	0.049 ± 0.0073	0.047 ± 0.0060
Testes	3.237 ± 0.2174	2.971 ± 0.2266	3.177 ± 0.1425	3.023 ± 0.1289
Epididymides	0.911 ± 0.0681	0.893 ± 0.0425	0.831 ± 0.0345^*	0.815 ± 0.0289^*
Lung	1.317 ± 0.0284	1.313 ± 0.1563	1.359 ± 0.0700	1.278 ± 0.1018
Thyroid/parathyroid	0.016 ± 0.0053	0.015 ± 0.0046	0.014 ± 0.0025	0.015 ± 0.0047
Female rats
Brain	1.780 ± 0.0734	1.740 ± 0.0536	1.825 ± 0.0755	1.758 ± 0.0998
Pituitary gland	0.010 ± 0.0034	0.010 ± 0.0025	0.010 ± 0.0023	0.011 ± 0.0017
Liver	7.387 ± 0.7843	6.397 ± 0.5466	7.076 ± 1.3626	6.948 ± 0.5587
Spleen	0.504 ± 0.0368	0.451 ± 0.0938	0.511 ± 0.1144	0.543 ± 0.0822
Heart	0.889 ± 0.1013	0.838 ± 0.0615	0.864 ± 0.1392	0.825 ± 0.0920
Thymus	0.455 ± 0.0396	0.433 ± 0.0476	0.447 ± 0.1072	0.460 ± 0.0314
Salivary glands	0.426 ± 0.0514	0.390 ± 0.0262	0.418 ± 0.0558	0.376 ± 0.0244
Kidneys	1.814 ± 0.1545	1.731 ± 0.1631	1.880 ± 0.2300	1.684 ± 0.1485
Adrenal glands	0.066 ± 0.0088	0.059 ± 0.0090	0.067 ± 0.0108	0.068 ± 0.0123
Ovaries	0.087 ± 0.0092	0.079 ± 0.0223	0.092 ± 0.0311	0.088 ± 0.0194
Lung	1.094 ± 0.0422	1.042 ± 0.0847	1.034 ± 0.1157	1.090 ± 0.1078
Thyroid/parathyroid	0.012 ± 0.0048	0.011 ± 0.0025	0.015 ± 0.0023	0.014 ± 0.0037
Uterus/cervix	0.614 ± 0.3916	0.458 ± 0.1359	0.617 ± 0.2779	0.402 ± 0.0820

Values are presented as the mean ± SD.
^* < 0.05 compared with the vehicle control.