Subacute Oral Toxicity of Yukmijiwhang-Tang in Crl:CD Sprague-Dawley Rats and Its Cytotoxicity
Table 7
Hematological values of animals treated with YMJ for 4 weeks.
Dose (mg/kg/day)
0
500
1000
2000
Male rats
WBC (103/μL)
13.17 ± 3.558
11.65 ± 3.265
14.15 ± 3.582
10.30 ± 3.453
Reticulocytes (%)
2.7 ± 0.33
2.4 ± 0.21
2.5 ± 0.31
2.6 ± 0.56
Neutrophils (%)
15.72 ± 4.759
13.54 ± 3.412
11.46 ± 3.400
13.06 ± 2.859
Lymphocytes (%)
78.9 ± 5.44
81.1 ± 2.97
83.0 ± 4.06
81.6 ± 2.72
Eosinophils (%)
0.9 ± 0.40
0.8 ± 0.18
0.8 ± 0.24
0.9 ± 0.57
Monocytes (%)
3.1 ± 0.54
3.2 ± 0.85
3.2 ± 0.97
3.1 ± 0.61
Basophils (%)
0.3 ± 0.04
0.3 ± 0.07
0.2 ± 0.00
0.3 ± 0.13
Large unstained cells (%)
1.2 ± 0.33
1.0 ± 0.23
1.3 ± 0.52
1.1 ± 0.31
RBC (106/μL)
7.92 ± 0.182
8.02 ± 0.458
7.75 ± 0.149
7.87 ± 0.321
Hemoglobin (g/dL)
15.5 ± 0.37
15.5 ± 0.58
15.4 ± 0.25
15.6 ± 0.55
Hematocrit (%)
46.3 ± 1.09
46.3 ± 1.70
45.8 ± 0.60
46.5 ± 1.49
MCV (fL)
58.4 ± 0.86
57.8 ± 1.65
59.2 ± 1.50
59.2 ± 1.71
MCH (pg)
19.5 ± 0.27
19.3 ± 0.74
20.0 ± 0.57
19.9 ± 0.30
MCHC (g/dL)
33.5 ± 0.62
33.4 ± 0.38
33.7 ± 0.40
33.6 ± 0.60
Platelet (103/μL)
1312 ± 107.8
1112 ± 89.7
1258 ± 168.9
1192 ± 132.3
PT (sec)
13.7 ± 0.13
13.7 ± 0.48
13.6 ± 0.19
13.9 ± 0.25
Female rats
WBC (103/μL)
9.28 ± 1.902
8.15 ± 1.819
8.79 ± 1.528
8.57 ± 0.896
Reticulocytes (%)
2.2 ± 0.35
1.9 ± 0.49
2.6 ± 0.85
2.0 ± 0.47
Neutrophils (%)
15.82 ± 4.190
15.70 ± 6.911
12.10 ± 4.552
19.00 ± 10.368
Lymphocytes (%)
78.7 ± 5.08
78.9 ± 6.51
82.7 ± 3.22
75.8 ± 10.93
Eosinophils (%)
0.9 ± 0.19
1.2 ± 0.24
1.2 ± 0.64
1.2 ± 0.15
Monocytes (%)
3.1 ± 1.17
3.0 ± 1.68
2.4 ± 0.92
2.8 ± 0.93
Basophils (%)
0.3 ± 0.09
0.2 ± 0.12
0.3 ± 0.04
0.2 ± 0.05
Large unstained cells (%)
1.2 ± 0.15
1.0 ± 0.25
1.3 ± 0.48
0.9 ± 0.32
RBC (106/μL)
7.63 ± 0.187
7.76 ± 0.313
7.72 ± 0.287
7.76 ± 0.224
Hemoglobin (g/dL)
15.1 ± 0.29
15.2 ± 0.49
15.3 ± 0.23
15.3 ± 0.30
Hematocrit (%)
44.6 ± 0.38
44.8 ± 1.25
45.4 ± 0.82
44.6 ± 0.76
MCV (fL)
58.5 ± 1.41
57.8 ± 1.21
58.9 ± 2.99
57.5 ± 1.08
MCH (pg)
19.7 ± 0.49
19.7 ± 0.58
19.8 ± 0.83
19.8 ± 0.47
MCHC (g/dL)
33.7 ± 0.40
34.0 ± 0.61
33.7 ± 0.57
34.4 ± 0.24
Platelet (103/μL)
1157 ± 74.5
1329 ± 119.5
1158 ± 71.5
1223 ± 127.7
PT (sec)
14.0 ± 0.29
13.8 ± 0.41
13.2 ± 0.18**
13.4 ± 0.51*
MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; PT, prothrombin time. Values are presented as the mean ± SD. * < 0.05 and ** < 0.01 compared with the vehicle control group.
