Huperzine A in the Treatment of Alzheimer's Disease and Vascular Dementia: A Meta-Analysis

Table 3

Incidence of adverse events for AD.

Adverse event	Number of subjects (pooled occurrence)		Odd ratio (fixed); 95% CI
	Huperzine A; (𝑛=360)	Placebo; (𝑛=373)
Agitation	3 (0.83)	3 (0.80)	1.04 [0.21, 5.17]
Ankles edema	1 (0.28)	0 (0.00)	3.12 [0.13, 76.76]
Anorexia	12 (3.33)	6 (1.60)	2.11 [0.78, 5.68]
Bradycardia	0 (0.00)	1 (0.27)	0.34 [0.01, 8.48]
Constipation	4 (1.11)	0 (0.00)	9.43 [0.51, 175.77]
Diarrhea	5 (1.39)	2 (0.54)	2.61 [0.50, 13.55]
Dizziness	9 (2.5)	12 (3.21)	0.77 [0.32, 1.85]
Dry mouth	4 (1.11)	0 (0.00)	9.43 [0.51, 175.77]
Diaphoresis	4 (1.11)	0 (0.00)	9.43 [0.51, 175.77]
Dimness of vision	0 (0.00)	1 (0.27)	0.34 [0.01, 8.48]
Festinating gait	0 (0.00)	1 (0.27)	0.34 [0.01, 8.48]
Headache	2 (0.56)	4 (1.07)	0.52 [0.09, 2.83]
Hyperactivity	5 (1.39)	3 (0.80)	1.74 [0.41, 7.32]
Hypopraxia	0 (0.00)	1 (0.27)	0.34 [0.01, 8.48]
Hypersomnia	4 (1.11)	0 (0.00)	9.43 [0.51, 175.77]
Indigestion	5 (1.39)	2 (0.54)	2.61 [0.50, 13.55]
Insomnia	6 (1.67)	6 (1.60)	1.04 [0.33, 3.24]
Mild bellyache	6 (1.67)	0 (0.00)	13.70 [0.77, 244.02]
Nasal obstruction	4 (1.11)	4 (1.07)	1.04 [0.26, 4.18]
Nausea or vomiting	15 (4.16)	5 (1.34)	3.20 [1.15, 8.90]