Evaluation of a Crataegus-Based Multiherb Formula for Dyslipidemia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Table 4

Changes in biochemical parameters at week 12.

	Placebo (𝑛=20)			Herb formula (𝑛=20)			𝑃 value; (versus placebo)
	Baseline	Week 12	% change	Baseline	Week 12	% change
Creatinine, μmol/L	70.5±13.1	68.1±14.2	−3.3±9.5	68.7±12.5	66.7±12.6	−2.5±9.9	0.799
Creatine kinase, U/L	144.3±72.8	135.7±78.7	−1.0 (−26.8, 10.1)	144.3±101.4	141.2±73.6	1.2 (−7.5, 15.0)	0.563
Total protein, g/L	75.2±3.3	76.1±3.1	1.3±3.7	74.4±4.2	75.1±3.3	1.1±3.8	0.860
Urea, mmol/L	4.78±1.18	5.13±1.15	10.2±24.6	5.35±1.29	5.13±1.36	−3.6±15.6	0.041
Albumin, g/L	44.9±2.4	45.3±2.2	0.9±4.5	43.5±2.7	45.0±2.6^∗∗	3.6±5.4	0.092
Bilirubin, 𝜇mol/L	12.6±5.5	13.1±6.8	4.9±25.2	12.1±4.0	11.9±5.2	1.4±32.2	0.706
ALT, IU/L	31.4±9.9	32.1±14.3	3.2±26.1	24.7±9.8	26.6±10.0	17.7±60.5	0.332
ALP, U/L	73.8±15.8	73.9±14.2	0.8±7.5	59.5±16.8	60.0±14.4	2.1±11.5	0.672
Urate, mmol/L	0.38±0.09	0.38±0.08	3.1±12.6	0.34±0.06	0.35±0.07	0.8±13.2	0.567

ALT: alanine aminotransferase; ALP: alkaline phosphatase; data are presented as mean ± SD or median (interquartile range); ^∗∗𝑃<0.01 compared to baseline.