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Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 378684, 6 pages
http://dx.doi.org/10.1155/2014/378684
Research Article

Role of JNK Activation and Mitochondrial Bax Translocation in Allicin-Induced Apoptosis in Human Ovarian Cancer SKOV3 Cells

1Department of Traditional Chinese Gynecology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
2Traditional Chinese Medicine University of Shanghai, Shanghai 201203, China
3Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai 200433, China

Received 2 January 2014; Revised 8 May 2014; Accepted 5 June 2014; Published 8 July 2014

Academic Editor: Leo M. Lee

Copyright © 2014 Ling Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Data. Result of human phospho-kinase array assays.

Allicin activated the AKT, P53, and JNK (c-Jun) pathway in SKOV3 cells were detected by human phospho-kinase array analysis. As shown, the first photo was negative control while the second was allicin (12.5μg/ml) intervention group; As a result, the signals of AKT and P53 were weakly different between the two photos; However, the signal of JNK was extremely increased in allicin group compared with the negative control. Therefore, JNK pathway was novel finding in this setting.

  1. Supplementary Material