Effects of Brown Seaweed (Sargassum polycystum) Extracts on Kidney, Liver, and Pancreas of Type 2 Diabetic Rat Model
Figure 1
Photomicrographs of pancreas tissues of rats from different experimental groups. (a) Normal control rats pancreatic endocrine and exocrine showing islets of Langerhans and acini (200x). (b) Diabetic rats pancreas shows degeneration and shrinkage (white arrow), vacuolar change (dashed black arrow), necrotic cells with pyknotic nuclei and acidophilic cytoplasm (black arrow), and disruption of normal endocrine architecture (200x). (c) Pancreas of metformin treated diabetic rats shows degeneration and shrinkage (irregular space in the islets of Langerhans—black arrow), swelling of the acinar epithelial lining and irregular arrangements (luminal disappearing—white arrow), and reduced necrosis (dashed black arrow) (200x). (d) Pancreas of 300 mg ethanol extract treated diabetic rats shows significantly reduced necrosis (dashed black arrow), reduced degeneration (black arrows), reduced irregular spaces (white arrow), and normal acinar epithelial lining (dashed white arrow) (200x). (e) Pancreas of 300 mg water extract treated diabetic rats shows significant cellular and architectural restoration, reduced necrosis (dashed black arrow), reduced degeneration (black arrows), minimum vacuolar degeneration (white arrow), and normal endocrine and exocrine (dashed white arrow) (200x). (f) Pancreas of 150 mg ethanol extract treated diabetic rats shows multifocal area of necrosis condensed nuclei and acidophilic cytoplasm (dashed black arrow), reduced cellular degeneration and reduced vacuolar swelling (black arrows), and normal exocrine (white arrow) (200x). (g) Pancreas of 150 mg water extract treated diabetic rats shows slight necrosis reduction (dashed black arrow), cellular degeneration and acute swelling (absence of spaces in the islets of Langerhans—black arrows), and irregular arrangement of the acinar epithelial lining (white arrow) (200x).
