Effects of Brown Seaweed (Sargassum polycystum) Extracts on Kidney, Liver, and Pancreas of Type 2 Diabetic Rat Model

Table 1

Changes in blood glucose level (mmol/L) of rats during the treatment period (Mean ± SE).

Days	NC	DC	DE300	DE150	DW300	DW150	DM
D 1	4.9 ± 0.3^Ba	20.3 ± 0.8^Aab	19.8 ± 2.5^Aa	20.7 ± 2.0^Aa	19.2 ± 1.3^Aa	19.3 ± 0.5^Aa	19.4 ± 2.0^Aa
D 7	5.4 ± 0.3^Ca	20.8 ± 1.7^Aab	17.3 ± 1.2^ABab	16.5 ± 0.7^Bb	18.1 ± 1.4^ABab	18.3 ± 0.8^ABa	16.1 ± 1.4^Bab
D 13	4.9 ± 0.1^Ca	18.3 ± 0.1^Ab	15.5 ± 0.7^ABb	15.4 ± 1.0^ABb	16.6 ± 1.6^ABab	20.1 ± 2.0^Aa	12.4 ± 3.0^Bb
D 19	5.4 ± 0.7^Ea	22.4 ± 0.6^Aa	14.6 ± 0.5^DCb	15.6 ± 1.1^BCb	15.9 ± 1.4^BCab	18.0 ± 0.4^Ba	11.9 ± 1.5^Db
D 22	5.2 ± 0.2^Ea	19.9 ± 1.1^Aab	14.6 ± 0.6^BCb	16.2 ± 1.2^BCb	14.2 ± 1.1^Cb	17.4 ± 1.1^ABa	10.5 ± 1.0^Db
HA; %	+5.80%; Increase	−2.00%; Decrease	−35.60%; Decrease	−27.80%; Decrease	−35.2%; Decrease	−10.92%; Decrease	−84.76%; Decrease

A,B,C,D,EValues with the same superscript/s within row do not differ significantly at 𝑃<0.05. a,b,cValues with the same superscript/s within column do not differ significantly at 𝑃<0.05  (𝑛=6). HA: hypoglycemic activity. NC: normal control group. DC: diabetic control group. DE300: diabetic group treated with 300 mg/kg/BW of the ethanolic extract. DE150: diabetic group treated with 150 mg/kg/BW of the ethanolic extract. DW300: diabetic group treated with 300 mg/kg/BW of the water extract. DW150: diabetic group treated with 150 mg/kg/BW of the water extract. DM: diabetic group treated with 250 mg/kg/BW of metformin.