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Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 381649, 6 pages
http://dx.doi.org/10.1155/2014/381649
Research Article

Long-Term Treatment with Aqueous Garlic and/or Tomato Suspensions Decreases Ehrlich Ascites Tumors

1Environmental and Experimental Pathology Post-Graduation, Paulista University (UNIP), Rua José Maria Whitaker 290, 05622-001 São Paulo, SP, Brazil
2Pharmacology Department, Federal University of São Paulo (UNIFESP), Rua Sena Madureira, 04021-001 São Paulo, SP, Brazil
3Veterinary Medicine, University Metodista of São Paulo, Rua Alfeu Tavares 149, 09641-000 São Bernardo do Campo, SP, Brazil

Received 23 February 2014; Revised 26 April 2014; Accepted 28 April 2014; Published 30 June 2014

Academic Editor: Khalid Rahman

Copyright © 2014 Jenifer Bom et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Y. Shukla and N. Kalra, “Cancer chemoprevention with garlic and its constituents,” Cancer Letters, vol. 247, no. 2, pp. 167–181, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. B. N. Ames, “Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases,” Science, vol. 221, no. 4617, pp. 1256–1263, 1983. View at Publisher · View at Google Scholar · View at Scopus
  3. J. G. Graham, M. L. Quinn, D. S. Fabricant, and N. R. Farnsworth, “Plants used against cancer—an extension of the work of Jonathan Hartwell,” Journal of Ethnopharmacology, vol. 73, no. 3, pp. 347–377, 2000. View at Publisher · View at Google Scholar · View at Scopus
  4. R. H. Liu, “Potential synergy of phytochemicals in cancer prevention: mechanism of action,” Journal of Nutrition, vol. 134, no. 12, pp. 3479S–3485S, 2004. View at Google Scholar · View at Scopus
  5. C. J. Schorah, “Micronutrients, vitamins, and cancer risk,” Vitamines & Hormones, vol. 57, pp. 1–23, 1997. View at Publisher · View at Google Scholar · View at Scopus
  6. F. Khanum, K. R. Anilakumar, and K. R. Viswanathan, “Anticarcinogenic properties of garlic: a review,” Critical Reviews in Food Science and Nutrition, vol. 44, no. 6, pp. 479–488, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. J. H. Woo, Y. H. Kim, Y. J. Choi et al., “Molecular mechanisms of curcumin-induced cytotoxicity:induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl–XL and IAP, the release of cytochrome c and inhibition of Akt,” Carcinogenesis, vol. 24, no. 7, pp. 1199–1208, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Hsu, B. Singh, and G. Schuster, “Induction of apoptosis in oral cancer cells: agents and mechanisms for potential therapy and prevention,” Oral Oncology, vol. 40, no. 5, pp. 461–473, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. N. Murthy, S. Mukherjee, G. Ray, and A. Ray, “Dietary factors and cancer chemoprevention: an overview of obesity-related malignancies,” Journal of Postgraduate Medicine, vol. 55, no. 1, pp. 45–54, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. N. Ota, F. Takano, S. Muroga et al., “Garlic extract and its selected organosulphur constituents promote ileal immune responses ex vivo,” Journal of Functional Foods, vol. 4, no. 1, pp. 243–252, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. E. Block, “The chemistry of garlic and onions,” Scientific American, vol. 252, no. 3, pp. 114–119, 1985. View at Google Scholar · View at Scopus
  12. J. P. Perchellet, E. M. Perchellet, and S. Belman, “Inhibition of DMBA-induced mouse skin tumorigenesis by garlic oil and inhibition of two tumor-promotion stages by garlic and onion oils,” Nutrition and Cancer, vol. 14, no. 3-4, pp. 183–193, 1990. View at Publisher · View at Google Scholar · View at Scopus
  13. J. A. Milner, “Garlic: its anticarcinogenic and antitumorigenic properties,” Nutrition Reviews, vol. 54, no. 11, pp. S82–S86, 1996. View at Google Scholar · View at Scopus
  14. A. Sengupta, S. Ghosh, S. Bhattacharjee, and S. Das, “Indian food ingredients and cancer prevention–An experimental evaluation of anticarcinogenic effects of garlic in rat colon,” Asian Pacific Journal of Cancer Prevention, vol. 5, no. 2, pp. 126–132, 2004. View at Google Scholar · View at Scopus
  15. M. Karas, H. Amir, D. Fishman et al., “Lycopene interferes with cell cycle progression and insulin-like growth factor I signaling in mammary cancer cells,” Nutrition and Cancer, vol. 36, no. 1, pp. 101–111, 2000. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Sengupta, S. Ghosh, and S. Das, “Modulatory influence of garlic and tomato on cyclooxygenase-2 activity, cell proliferation and apoptosis during azoxymethane induced colon carcinogenesis in rat,” Cancer Letters, vol. 208, no. 2, pp. 127–136, 2004. View at Publisher · View at Google Scholar · View at Scopus
  17. L. Tang, T. Jin, X. Zeng, and J. S. Wang, “Lycopene inhibits the growth of human androgen-independent prostate cancer cells in vitro and in BALB/c nude mice,” Journal of Nutrition, vol. 135, no. 2, pp. 287–290, 2005. View at Google Scholar · View at Scopus
  18. A. Basu and V. Imrhan, “Tomatoes versus lycopene in oxidative stress and carcinogenesis: conclusions from clinical trials,” European Journal of Clinical Nutrition, vol. 61, no. 3, pp. 295–303, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. S. R. Kleeb, J. G. Xavier, R. Frussa-Filho, and M. L. Z. Dagli, “Effect of haloperidol on the development of the solid Ehrlich tumor in mice,” Life Sciences, vol. 60, no. 4-5, pp. 69–74, 1997. View at Google Scholar · View at Scopus
  20. M. L. Z Dagli, J. L. Guerra, and P. H. N. Saldiva, “An experimental study on the lymphatic dissemination of the solid Ehrlich tumor in mice,” Brazilian Journal of Veterinary Research and Animal Science, vol. 29, pp. 97–103, 1992. View at Google Scholar
  21. D. Ploton, M. Menager, P. Jeannesson, G. Himber, F. Pigeon, and J. J. Adnet, “Improvement in the staining and in the visualization of the argyrophilic proteins of the nucleolar organizer region at the optical level,” The Histochemical Journal, vol. 18, no. 1, pp. 5–14, 1986. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Aubele, S. Biesterfeld, M. Derenzini et al., “Guidelines of AgNOR quantitation. Committee on AgNOR quantitation within the European Society of pathology,” Zentralblatt für Pathologie, vol. 140, no. 1, pp. 107–108, 1994. View at Google Scholar · View at Scopus
  23. S. Mirunalini, G. Dhamodharan, and K. A. Karthishwaran, “Natural wonder drug helps to prevent cancer: garlic oil,” Notulae Scientia Biologicae, vol. 2, pp. 14–19, 2010. View at Google Scholar
  24. A. Herzog, U. Siler, V. Spitzer et al., “Lycopene reduced gene expression of steroid targets and inflammatory markers in normal rat prostate,” The FASEB Journal, vol. 19, no. 2, pp. 272–274, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Porrini, P. Riso, A. Brusamolino, C. Berti, S. Guarnieri, and F. Visioli, “Daily intake of a formulated tomato drink affects carotenoid plasma and lymphocyte concentrations and improves cellular antioxidant protection,” British Journal of Nutrition, vol. 93, no. 1, pp. 93–99, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. J. A. Segura, L. G. Barbero, and J. Márquez, “Ehrlich ascites tumour unbalances splenic cell populations and reduces responsiveness of T cells to Staphylococcus aureus enterotoxin B stimulation,” Immunology Letters, vol. 74, no. 2, pp. 111–115, 2000. View at Publisher · View at Google Scholar · View at Scopus
  27. P. C. Bergami-Santos, M. Mariano, and J. A. M. Barbuto, “Dual role of polymorphonuclear neutrophils on the growth of Ehrlich ascites tumor (EAT) in mice,” Life Sciences, vol. 75, no. 2, pp. 245–255, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. D. Fecchio, P. Sirois, M. Russo, and S. Jancar, “Studies on inflammatory response induced by Ehrlich tumor in mice peritoneal cavity,” Inflammation, vol. 14, no. 1, pp. 125–132, 1990. View at Publisher · View at Google Scholar · View at Scopus
  29. I. Das and T. Saha, “Effect of garlic on lipid peroxidation and antioxidation enzymes in DMBA-induced skin carcinoma,” Nutrition, vol. 25, no. 4, pp. 459–471, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. O. Halevy and D. Sklan, “Inhibition of arachidonic acid oxidation by β-carotene, retinol and α-tocopherol,” Biochimica et Biophysica Acta: Lipids and Lipid Metabolism, vol. 918, no. 3, pp. 304–307, 1987. View at Publisher · View at Google Scholar · View at Scopus
  31. J. K. Willcox, S. L. Ash, and G. L. Catignani, “Antioxidants and prevention of chronic disease,” Critical Reviews in Food Science and Nutrition, vol. 44, no. 4, pp. 275–295, 2004. View at Publisher · View at Google Scholar · View at Scopus
  32. P. Rose, M. Whiteman, P. K. Moore, and Y. Z. Zhu, “Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents,” Natural Product Reports, vol. 22, no. 3, pp. 351–368, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. V. Canet, M. P. Montmasson, Y. Usson, F. Giroud, and G. Brugal, “Correlation between silver-stained nucleolar organizer region area and cell cycle time,” Cytometry, vol. 43, pp. 110–116, 2001. View at Publisher · View at Google Scholar
  34. E. S. Freitas, E. D. Leite, A. E. Silva et al., “Effect of thyroxine and propylthiouracil in ehrlich ascitic tumor cells,” International Journal of Morphology, vol. 24, no. 4, pp. 665–671, 2006. View at Google Scholar · View at Scopus