Research Article
Pharmacokinetic and Pharmacodynamic Comparison of Chinese Herbal Ointment Liu-He-Dan and Micron Liu-He-Dan Ointment in Rats with Acute Pancreatitis
Table 2
Pharmacodynamic parameters of LHD and MLHD in the pancreas at 48 h after topical use.
| | | Amylase
(U/L) | MDA
(nmol/mg) | SOD
(U/mgprot) | TNF-α
(pg/mL) | IL-6
(pg/mL) | IL-10
(pg/mL) | Pathologic score |
| | Normal | 1504 ± 372 | 0.03 ± 0.01 | 4.2 ± 1.5 | 0.06 ± 0.02 | 0.09 ± 0.03 | 0.37 ± 0.01 | 0.22 ± 0.22 | | AP model | 4339 ± 611* | 0.10 ± 0.03* | 2.2 ± 1.1* | 0.12 ± 0.05* | 0.16 ± 0.04* | 0.42 ± 0.04 | 5.63 ± 1.31* | | LHD | 2971 ± 730# | 0.05 ± 0.02# | 5.5 ± 1.9# | 0.06 ± 0.01# | 0.09 ± 0.03# | 0.33 ± 0.06 | 5.53 ± 2.27 | | MLHD | 2517 ± 244# | 0.06 ± 0.02# | 5.8 ± 2.1# | 0.06 ± 0.01# | 0.08 ± 0.02# | 0.34 ± 0.03 | 5.75 ± 2.04 |
|
|
Compared with normal, *; compared with AP, #.
MDA: malondialdehyde; SOD: superoxide dismutase.
|
