Pharmacokinetic Alteration of Baclofen by Multiple Oral Administration of Herbal Medicines in Rats
Table 2
Population pharmacokinetic parameter estimates for baclofen obtained after oral administration of baclofen (1 mg/kg) to each pretreated group. Distilled water (control) or each herbal medicine, that is, Oyaksungisan (OY) or Achyranthes bidentata radix (AB) extract, was administered orally for 7 consecutive days. On the final day, baclofen was administered orally after 10 min of the distilled water or each herbal medicine.