Puerarin Attenuates Cerebral Damage by Improving Cerebral Microcirculation in Spontaneously Hypertensive Rats

Table 1

Effect of puerarin on mean arterial blood pressure (MAP), blood perfusion, and microvessel diameter in Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHRs).

Groups	Heart rate	MAP	Blood perfusion	Microvessel diameter (𝜇m)
	(beat/min)	(mmHg)	(PU)	Arterioles	Venule
WKY
Control	389±21	83.72±7.82	4.89±1.09	42.64±10.43	44.72±9.51
Vehicle	387±12	90.73±19.67	3.33±0.89	44.78±6.04	43.66±4.51
Puerarin	391±28	91.51±13.58	4.16±0.18	47.8±10.91	43.78±4.04
SHRs
Control	401±26	99.80±16.16^∗	4.43±0.77	42.82±7.69	33.29±8.24
Vehicle	398±38	105.92±22.61	3.84±0.82	42.84±6.83	46.08±15.67
Puerarin	382±21	85.56±15.62^#	3.83±0.89	55.20±15.12^#	47.20±15.13
Nimodipine	378±35	113.38±10.10^#	4.76±0.58	49.94±12.74^#	41.74±7.09

Data are mean ± SD, 𝑛=7. PU: perfusion unit. *𝑃<0.05 compared with WKY control group; ^#𝑃<0.05 compared with SHRs vehicle.