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Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 408503, 9 pages
http://dx.doi.org/10.1155/2014/408503
Research Article

Auraptene in the Peels of Citrus kawachiensis (Kawachi Bankan) Ameliorates Lipopolysaccharide-Induced Inflammation in the Mouse Brain

1Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan
2Department of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan
3Department of Planning and Development, Ehime Beverage Inc., 478 Anjyoji, Matsuyama, Ehime 791-8603, Japan

Received 27 December 2013; Revised 25 January 2014; Accepted 27 January 2014; Published 15 May 2014

Academic Editor: Ke Ren

Copyright © 2014 Satoshi Okuyama et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Q. Wang, X. N. Tang, and M. A. Yenari, “The inflammatory response in stroke,” The Journal of Neuroimmunology, vol. 184, no. 1-2, pp. 53–68, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. C. Iadecola and J. Anrather, “The immunology of stroke: from mechanisms to translation,” Nature Medicine, vol. 17, no. 7, pp. 796–808, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Okuyama, S. Minami, N. Shimada, N. Makihata, M. Nakajima, and Y. Furukawa, “Anti-inflammatory and neuroprotective effect of auraptene, a Citrus coumarin, following cerebral global ischemia in mice,” Eurpean Journal of Pharmacology, vol. 699, no. 1–3, pp. 118–123, 2013. View at Publisher · View at Google Scholar
  4. Y. Furukawa, S. Okuyama, Y. Amakura et al., “Isolation and characterization of activators of ERK/MAPK from Citrus plants,” International Journal of Molecular Sciences, vol. 13, no. 2, pp. 1832–1845, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. Y. Amakura, M. Yoshimura, K. Ouchi, S. Okuyama, Y. Furukawa, and T. Yoshida, “Characterization of constituents in peel of Citrus kawachiensis (Kawachibankan),” Bioscience, Biotechnology, and Biochemistry, vol. 77, no. 9, pp. 1977–1980, 2013. View at Publisher · View at Google Scholar
  6. S. Okuyama, N. Makihata, M. Yoshimura et al., “Oenothein B suppresses lipopolysaccharide (LPS)-induced inflammation in the mouse brain,” International Journal of Molecular Science, vol. 14, no. 5, pp. 9767–9778, 2013. View at Publisher · View at Google Scholar
  7. C. B. Lawrence, D. Brough, and E. M. Knight, “Obese mice exhibit an altered behavioural and inflammatory response to lipopolysaccharide,” Disease Models & Mechanisms, vol. 5, no. 5, pp. 649–659, 2012. View at Publisher · View at Google Scholar
  8. R. Yirmiya, “Endotoxin produces a depressive-like episode in rats,” Brain Research, vol. 711, no. 1-2, pp. 163–174, 1996. View at Publisher · View at Google Scholar · View at Scopus
  9. G. W. Kreutzberg, “Microglia: a sensor for pathological events in the CNS,” Trends in Neurosciences, vol. 19, no. 8, pp. 312–318, 1996. View at Publisher · View at Google Scholar · View at Scopus
  10. Z. Chen, W. Jalabi, K. B. Shpargel et al., “Lipopolysaccharide-induced microglial activation and neuroprotection against experimental brain injury is independent of hematogenous TLR4,” The Journal of Neuroscience, vol. 32, no. 34, pp. 11706–11715, 2012. View at Publisher · View at Google Scholar
  11. A. M. Blanco, S. L. Vallés, M. Pascual, and C. Guerri, “Involvement of TLR4/type I IL-1 receptor signaling in the induction of inflammatory mediators and cell death induced by ethanol in cultured astrocytes,” The Journal of Immunology, vol. 175, no. 10, pp. 6893–6899, 2005. View at Google Scholar · View at Scopus
  12. Y. Dong and E. N. Benveniste, “Immune function of astrocytes,” Glia, vol. 36, no. 2, pp. 180–190, 2001. View at Publisher · View at Google Scholar · View at Scopus
  13. D. W. Chung, K.-Y. Yoo, I. K. Hwang et al., “Systemic administration of lipopolysaccharide induces cyclooxygenase-2 immunoreactivity in endothelium and increases microglia in the mouse hippocampus,” Cellular and Molecular Neurobiology, vol. 30, no. 4, pp. 531–541, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. Y. C. Oh, W. K. Cho, Y. H. Joeng, G. Y. Im, Y. H. Hwang, and J. Y. Ma, “Anti inflammatory effect of Citrus unshiu peel in LPS-stimulated RAW 264.7 macrophage cells,” The American Journal of Clinical Medicine, vol. 40, no. 3, pp. 611–629, 2012. View at Publisher · View at Google Scholar
  15. M. Cavia-Saiz, M. D. Busto, M. C. Pilar-Izquierdo, N. Ortega, M. Perez-Mateos, and P. Muñiz, “Antioxidant properties, radical scavenging activity and biomolecule protection capacity of flavonoid naringenin and its glycoside naringin: a comparative study,” Journal of the Science of Food and Agriculture, vol. 90, no. 7, pp. 1238–1244, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. Y.-H. Lu, M.-Y. Su, H.-Y. Huang, L.-L. Li, and C.-G. Yuan, “Protective effects of the Citrus flavanones to PC12 cells against cytotoxicity induced by hydrogen peroxide,” Neuroscience Letters, vol. 484, no. 1, pp. 6–11, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. S. K. Ha, H. Y. Park, H. Eom, Y. Kim, and I. Choi, “Narirutin fraction from Citrus peel attenuates LPS-stimulated inflammatory response through inhibition of NF-κB and MSPKs activation,” Food Chemical and Tixicology, vol. 50, no. 10, pp. 3498–3504, 2012. View at Publisher · View at Google Scholar
  18. V. Gaur, A. Aggarwal, and A. Kumar, “Protective effect of naringin against ischemic reperfusion cerebral injury: possible neurobehavioral, biochemical and cellular alterations in rat brain,” European Journal of Pharmacology, vol. 616, no. 1–3, pp. 147–154, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Golechha, U. Chaudhry, J. Bhatia, D. Saluja, and D. S. Arya, “Naringin protects against kainic acid-induced status epilepticus in rats: evidence for an antioxidant, anti-inflammatory and neuroprotective intervention,” Biological and Pharmaceutical Bulletin, vol. 34, no. 3, pp. 360–365, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. K. Gopinath and G. Sudhandiran, “Naringin modulates oxidative stress and inflammation in 3-nitropropionic acid-induced neurodegeneration through the activation of nuclear factor-erythroid 2-related factor-2 signaling pathway,” Neuroscience, vol. 227, no. 27, pp. 134–143, 2012. View at Publisher · View at Google Scholar
  21. A. Kumar, S. Dogra, and A. Prakash, “Protective effect of naringin, a Citrus flavonoid, against colchicine-induced cognitive dysfunction and oxidative damage in rats,” Journal of Medicinal Food, vol. 13, no. 4, pp. 976–984, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Kumar, A. Prakash, and S. Dogra, “Naringin alleviates cognitive impairment, mitochondrial dysfunction and oxidative stress induced by D-galactose in mice,” Food and Chemical Toxicology, vol. 48, no. 2, pp. 626–632, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. D.-M. Wang, Y.-J. Yang, L. Zhang, F.-F. Guan, and L.-F. Zhang, “Naringin enhances CaMK II activity and improves long-term memory in a mouse model of Alzheimer’s disease,” International Journal of Molecular Science, vol. 14, no. 3, pp. 5576–5586, 2013. View at Publisher · View at Google Scholar
  24. W. Zou, C. Yang, and W. Su, “Tissue distribution study of naringin in rats by liquid chromatography-tandem mass spectrometry,” Arzneimittelforschuing, vol. 62, no. 4, pp. 181–186, 2012. View at Publisher · View at Google Scholar
  25. E. G. McGeer, A. Klegeris, and P. L. McGeer, “Inflammation, the complement system and the diseases of aging,” Neurobiology of Aging, vol. 26, supplement 1, pp. S94–S97, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. L. Qin, X. Wu, M. L. Block et al., “Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration,” Glia, vol. 55, no. 5, pp. 453–462, 2007. View at Publisher · View at Google Scholar · View at Scopus