Evidence-Based Complementary and Alternative Medicine / 2014 / Article / Tab 1

Review Article

The Effect of Complementary and Alternative Medicine on Subfertile Women with In Vitro Fertilization

Table 1

Summary of randomized studies of the effect of acupuncture on IVF outcomes.

Study IDDesignSample sizeInterventionsOutcomesLimitation

20RCT273Treatment arm: acupuncture intervention
Control arm: no intervention
Treatment arm: PR, 39% [37 of 95]
Control arm: PR, 26% [21 of 87]
Not mentioned blindness
Small sample size

19RCT160Treatment arm: acupuncture intervention
Control arm: no intervention
Treatment arm: PR, 42.5% [34 of 80]
Control arm: PR, 26.3% [21 of 80]
Not mentioned blindness
Small sample size

21Single-blind, RCT228Treatment arm: acupuncture intervention
Control arm: no intervention
Treatment arm: PR, 31% [33 of 107]
Control arm: PR, 23% [26 of 114]
Single-blind trial
Small sample size

22RCT225Treatment arm: acupuncture intervention
Control arm: no intervention
Treatment arm: PR, 33.6% [39 of 116]
Control arm: PR, 15.6% [17 of 109]
Not mentioned blindness
Small sample size

37Single-blind, RCT150Treatment arm: acupuncture intervention
Control arm: no intervention
Treatment arm: PR, 50% [39 of 78]
Control arm: PR, 42.6% [29 of 68]
Single-blind trial
Small sample size

59RCT44Treatment arm: acupuncture intervention
Control arm: no intervention
Treatment arm: PR, 30% [9 of 30]
Control arm: PR, 28.6% [4 of 14]
Not mentioned blindness
Small sample size

35Double-blind, RCT370 Treatment arm: acupuncture intervention
Control arm: placebo acupuncture intervention
Treatment arm: PR, 55.1 [102 of 185]#
Control arm: PR, 43.8% [81 of 185]

36Double-blind, RCT226Treatment arm: acupuncture intervention
Control arm: placebo acupuncture intervention
There were no significant differences in outcomes of PR, OPR, LBR, and IR in the placebo acupuncture group than in the real acupuncture groupSmall sample size

34Double-blinded, RCT635Treatment arm: acupuncture intervention
Control arm: placebo acupuncture intervention
There were no significant differences in outcomes of OPR and LBR and IR between the placebo acupuncture group and the real acupuncture group

39RCT416Treatment arm: acupuncture intervention
Control arm: no intervention
There was no significantly increased PR in the acupuncture group than in the control group Not mentioned blindness

44Double-blinded, RCT160Treatment arm: acupuncture intervention
Control arm: placebo acupuncture intervention
CPR had no significant difference between the true acupuncture group and the sham acupuncture groupSmall sample size

32RCT66Treatment arm: acupuncture intervention
Control arm: no intervention
The fertilization rate, cleavage rate, and the rate of high-quality embryos were all significantly higher in the acupuncture group than in the control groupNot mentioned blindness
Small sample size

Note: RCT: randomized clinical trial; PR: pregnancy rate; OPR: ongoing pregnancy rate; LBR: live birth rate; IR: implantation rate; FR: fertilization rate; CR: cleavage rate. versus treatment arm; # versus control arm.

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