Research Article

Influence of First-Line Antibiotics on the Antibacterial Activities of Acetone Stem Bark Extract of Acacia mearnsii De Wild. against Drug-Resistant Bacterial Isolates

Table 1

Average inhibition zones (±1.0 mm) produced by acetone extract of Acacia mearnsii and their different combinations.

AMA aloneEry aloneCombined AMA + EryTet aloneCombined AMA + Tet
5102062.51252501.25 + 62.52.5 + 1255 + 25062.51252501.25 + 62.52.5 + 1255 + 250
mg/mLµg/mLmg/mL + µg/mLµg/mLmg/mL + µg/mL

Escherichia  coli ATCC 25922131518000000222427222528
Bacillus  cereus ATCC 10702172023252830202327252731252832
Pseudomonas  aeruginosa ATCC 19582161821263034212325222528252730
Serratia  marcescens ATCC 998601418000000161822151822
Enterococcus  faecalis KZN172023000000000000
Staphylococcus  aureus OK1171921283033252628313436303438
Salmonella  typhi ATCC 1331125293200001416293133313336
Micrococcus  luteus 141619202327172024222630273033
Proteus  vulgaris CSIR 0030182123222325222425232628252730
Shigella  flexneri KZN202224252730152731222325252628

AMA aloneMet aloneCombined AMA + MetAmx aloneCombine AMA + Amx
5102062.51252501.25 + 62.52.5 + 1255 + 25062.51252501.25 + 62.52.5 + 1255 + 250
mg/mLµg/mLmg/mL + µg/mLµg/mLmg/mL + µg/mL

Escherichia  coli ATCC 259221315180152001517222427222427
Bacillus  cereus ATCC 10702172023000172022151820182022
Pseudomonas  aeruginosa ATCC 19582161821000141719202122192022
Serratia  marcescens ATCC 99860141800001418141720172023
Enterococcus  faecalis KZN172023000172023000000
Staphylococcus  aureus OK1171921000162124283032272932
Salmonella  typhi ATCC 1331125293200001518283234303537
Micrococcus  luteus 141619000111416283236333640
Proteus  vulgaris CSIR 003018212300014161818202220232
Shigella  flexneri KZN202224000151820192023222526

AMA aloneCip aloneCombined AMA + Cip Nal aloneCombined AMA + Nal
510201.252.551.25 + 1.252.5 + 2.55 + 562.51252501.25 + 62.52.5 + 1255 + 250
mg/mLµg/mLmg/mL + µg/mLµg/mLmg/mL + µg/mL

Escherichia  coli ATCC 25922131518303335202427252730202428
Bacillus  cereus ATCC 10702172023202427182227202528171922
Pseudomonas  aeruginosa ATCC 19582161821212528182125242730171924
Serratia  marcescens ATCC 998601418323540262932273033252830
Enterococcus  faecalis KZN172023333842212428000000
Staphylococcus  aureus OK1171921303538252730000151821
Salmonella  typhi ATCC 13311252932323740151618293234242629
Micrococcus  luteus 141619232832192427000000
Proteus  vulgaris CSIR 0030182123252628232527242630232529
Shigella  flexneri KZN202224283033303235182022202123

AMA aloneChl aloneCombined AMA + Chl Kan aloneCombined AMA + Kan
5102062.51252501.25 + 62.52.5 + 1255 + 25062.51252501.25 + 62.52.5 + 1255 + 250
mg/mLµg/mLmg/mL + µg/mLµg/mLmg/mL + µg/mL

Escherichia  coli ATCC 25922131518222530161921232528162023
Bacillus  cereus ATCC 10702172023252830192024242730151721
Pseudomonas  aeruginosa ATCC 19582161821252830202226222528202326
Serratia  marcescens ATCC 998601418000162024232528192426
Enterococcus  faecalis KZN172023000000000000
Staphylococcus  aureus OK1171921212528172023182227222628
Salmonella  typhi ATCC 13311252932303235232730283032293234
Micrococcus  luteus 141619293035202427222528202426
Proteus  vulgaris CSIR 0030182123252830252628232628252729
Shigella  flexneri KZN202224252729252628192325232527

AMA: acetone extract of A. mearnsii; Ery: erythromycin; Tet: tetracycline; Met: metronidazole; Cip: ciprofloxacin; Nal: nalidixic acid; Chl: chloramphenicol; Kan: kanamycin.