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Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 429256, 8 pages
Research Article

Mechanisms Underlying the Antinociceptive, Antiedematogenic, and Anti-Inflammatory Activity of the Main Flavonoid from Kalanchoe pinnata

1Laboratory of Pharmacology, Department of Physiological Sciences, Institute of Biology, Federal Rural University of Rio de Janeiro, BR 465, Km 07, 23890-000 Seropédica, RJ, Brazil
2Núcleo de Pesquisa de Produtos Naturais, Universidade Federal do Rio de Janeiro, Avenida Carlos Chagas Filho 373, 21941-902 Cidade Universitária, RJ, Brazil
3Universidade Federal de Goiás, Instituto de Ciências Biológicas, Departamento de Ciências Fisiológicas, 74001-970 Goiânia, GO, Brazil

Received 30 July 2014; Revised 2 November 2014; Accepted 6 November 2014; Published 11 December 2014

Academic Editor: Jae Youl Cho

Copyright © 2014 Raquel Teixeira Ferreira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

HPLC chromatograms of Kalanchoe pinnata flowers aqueous extract, organic fractions (EtOAcF and BuOHF), and isolated flavonoid [quercetin 3-O-α-L-arabinopyranosyl (1→2) α-L-rhamnopyranoside] (KPFV) are available on Supplementary Material. HPLC analyses were performed on a Shimadzu SPD-M10A VP instrument, using an RP-18 reverse-phase column (5 μm, 250 mm x 4 mm, Lichro-CART/Lichrospher 100; Merck). The main flavonoid in K. pinnata is abundant in both fractions. 1H and 13 spectra of the flavonoid, recorded on a Varian MR-500 NMR spectrometer (1H: 500 MHz; 13C: 125 MHz), are also available.

  1. Supplementary Material