Gyejigachulbu-Tang Relieves Oxaliplatin-Induced Neuropathic Cold and Mechanical Hypersensitivity in Rats via the Suppression of Spinal Glial Activation

Figure 1

Effects of GBT on oxaliplatin-induced cold and mechanical hypersensitivity. (a) The average tail withdrawal latency in response to cold stimuli prior to (left) and 3 days (middle) and 5 days (right) after an oxaliplatin (6 mg/kg, i.p.) injection. (b) The mechanical threshold in response to von Frey hair stimuli prior to (left) and 3 days (middle) and 5 days (right) after an oxaliplatin (6 mg/kg, i.p.) injection. Data are presented as .^*, ^*** versus NS/Vehicle; ^##, ^### versus NS/Oxali by one-way ANOVA followed by Dunnett’s post hoc test.

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