Effects of Danshen Ethanol Extract on the Pharmacokinetics of Fexofenadine in Healthy Volunteers

<div>Induction of MDR1 mRNA by tanshinone I (TanI), cryptotanshinone (Cry), and tanshinone IIA (Tan IIA). Human hepatocytes were exposed to tanshinone I (2 <i>μ</i>M, 10 <i>μ</i>M), cryptotanshinone (2 <i>μ</i>M, 10 <i>μ</i>M), tanshinone IIA (2 <i>μ</i>M, 10 <i>μ</i>M), or 25 <i>μ</i>M rifampin (PC) for 3 days. MDR1 mRNA levels were measured with reverse transcription real-time PCR. These data were obtained from two independent experiments, and each experiment was performed in triplicate. Each column with bar represents the mean and S.D. The mean is expressed as fold induction over vehicle control (NC).</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 3

Figure 3: Effects of Danshen Ethanol Extract on the Pharmacokinetics of Fexofenadine in Healthy Volunteers 