TY - JOUR
A2 - Albuquerque, Ulysses Paulino
AU - De Queiroz, Aline Cavalcanti
AU - Dias, Thays de Lima Matos Freire
AU - Da Matta, Carolina Barbosa Brito
AU - Cavalcante Silva, Luiz Henrique Agra
AU - de Araújo-Júnior, João Xavier
AU - Araújo, Givanildo Bernardino de
AU - Moura, Flávia de Barros Prado
AU - Alexandre-Moreira, Magna Suzana
PY - 2014
DA - 2014/07/13
TI - Antileishmanial Activity of Medicinal Plants Used in Endemic Areas in Northeastern Brazil
SP - 478290
VL - 2014
AB - This study investigates the leishmanicidal activity of five species of plants used in folk medicine in endemic areas of the state of Alagoas, Brazil. Data were collected in the cities of Colonia Leopoldina, Novo Lino, and União dos Palmares, Alagoas state, from patients with cutaneous leishmaniasis (Leishmania amazonensis) who use medicinal plants to treat this disease. Plants extracts were tested at a concentration of 1–100 μg/mL in all experiments, except in an assay to evaluate activity against amastigotes, when 10 μg/mL was used. All plants extracts did not show deleterious activity to the host cell evidenced by LDH assay at 100, 10, and 1 μg/mL after 48 h of incubation. The plants extracts Hyptis pectinata (L.) Poit, Aloe vera L., Ruta graveolens L., Pfaffia glomerata (Spreng.) Pedersen, and Chenopodium ambrosioides L. exhibited direct activity against extracellular forms at 100 μg/mL; these extracts inhibited growth by 81.9%, 82.9%, 74.4%, 88.7%, and 87.4%, respectively, when compared with promastigotes. The plants extracts H. pectinata, A. vera, and R. graveolens also significantly diminished the number of amastigotes at 10 μg/mL, inhibiting growth by 85.0%, 40.4%, 94.2%, and 97.4%, respectively, when compared with control. Based on these data, we conclude that the five plants exhibited considerable leishmanicidal activity.
SN - 1741-427X
UR - https://doi.org/10.1155/2014/478290
DO - 10.1155/2014/478290
JF - Evidence-Based Complementary and Alternative Medicine
PB - Hindawi Publishing Corporation
KW -
ER -