Paeonol Inhibits Proliferation of Vascular Smooth Muscle Cells Stimulated by High Glucose via Ras-Raf-ERK1/2 Signaling Pathway in Coculture Model

Figure 5

Effect of paeonol on VEGF and PDGF-B expression in VECs. VEGF (a and b) and PDGF-B (c and d) expression in VECs was performed through immunocytochemical staining as described in Section 2. (A) NG (5.5 mM); (B) HG (35.5 mM); (C) HG + Pae (30 μM); (D) HG + Pae (60 μM); (E) HG + Pae (120 μM); (F) HG + Sunitinib (0.135 μM). ^##𝑃<0.01 versus NG (5.5 mM) group; *𝑃<0.05, **𝑃<0.01 versus HG (35.5 mM) group.

(a)

(b)

(c)

(d)