The Effects of Herbs and Fruits on Leukaemia

Table 2

Biological properties of some fruits with antileukaemic effect.

Names of fruits	Activity/uses	Human/animal subjects	Results	References
Grape seed	(i) Cell death; (ii) Apoptosis	Leukaemic cells	(i) Forces leukaemia cells to commit cell suicide; (ii) Activation of the JNK pathway	Ning et al., 2009 [38]
Pomegranate	(i) Antioxidant; (ii) Antileukaemic	Leukaemia cell lines	The acetonitrile fractions decreased (ATP) levels in all leukaemic cell lines	Dahlawi et al., 2013 [39]
Carrot	Strong source of bioactive chemicals for the treatment of leukaemia	Leukaemia cell lines	Antileukaemic	Zaini et al., 2011 [40]
Ganoderma lucidum	Antitumour	WEHI-3 leukaemic cells (BALB/c mice)	(i) It decreased the weight of spleens as compared with control mice; (ii) To increase the percentages of CD3 and CD19 but decrease the percentages of Mac-3 and CD11b markers	Chang et al., 2009 [41]
Berberis vulgaris (berberine)	(i) Antioxidant; (ii) Antimicrobial; (iii) Anticancer	HL-60 & WEHI-3	(i) Suppress the growth and proliferation of different HL-60; (ii) Induced G1-phase cell cycle arrest; (iii) Influence p53; (iv) Anticancer activity against leukaemic cells (WEHI-3)	Andola et al., 2010 [42]; Kulkarni and Dhir 2010 [43]