Neuroprotective Effects of Jitai Tablet, a Traditional Chinese Medicine, on the MPTP-Induced Acute Model of Parkinson’s Disease: Involvement of the Dopamine System

Figure 5

JTT protected against MPTP-induced reductions in D₂R expression in the mouse striatum as measured by autoradiography. MPTP (20 mg/kg, 4 times, at 2-hour interval, i.p.) was injected on the 8th day of the 15-day experiment period. Mice were sacrificed for the autoradiography study on the 7th day after MPTP injections. [¹²⁵I]-IBZM D₂ binding is shown in autoradiograms (a). A decrease in D₂R expression was observed in MPTP mice. Treatment with JTT partially prevented this decrease. Radioactivity binding of D₂ in the striatum (b) is expressed as the mean ± S.D, 𝑛=5. *𝑃<0.05, **𝑃<0.01 versus vehicle group.

(a)

(b)