Neuroprotective Effects of Jitai Tablet, a Traditional Chinese Medicine, on the MPTP-Induced Acute Model of Parkinson’s Disease: Involvement of the Dopamine System

Figure 6

JTT inhibited the increase in the ratio of DOPAC and HVA to DA in the striatum of MPTP mice. MPTP (20 mg/kg, 4 times, at 2-hour interval, i.p.) was injected on the 8th day of 15-day experiment period. The contents of DA, DOPAC, and HVA were detected by HPLC-ECD and the ratio of (DOPAC + HVA) to DA was calculated. Data regarding DA, DOPAC, HVA (a), and (DOPAC + HVA)/DA ratios (b) are expressed as the mean ± S.D, 𝑛=4-5. *𝑃<0.05, **𝑃<0.01 versus vehicle group.

(a)

(b)