Connectomics: A New Direction in Research to Understand the Mechanism of Acupuncture

Table 1

Studies on the acupuncture and cerebral functional connectivity.

Author	Year	Language	Participants	Case number	Group number	Intervention	Points	Control
Qin et al. [24]	2006	E	HS	14	1	MA	ST36	Baseline versus after acupuncture
Bai et al. [39]	2007	E	HS	8	2	MA	ST36	Acupuncture versus sham acupuncture
Napadow et al. [33]	2007	E	CTS, HS	25 (13 CTS patients)	2	MA	LI-4	Baseline versus after acupuncture; CTS patients versus HS
Qin et al. [40]	2008	E	HS	18	2	MA	ST36	Acupuncture versus sham acupuncture
Dhond et al. [41]	2008	E	HS	15	2	MA	left PC6	Acupuncture versus sham acupuncture
Zhang et al. [30]	2009	E	HS	36	3	EA	GB 37, KI 8	EA versus light flash stimulation
Liu et al. [42]	2009	E	HS	56	4	EA	GB37, BL60, KI8, a sham point	Acupuncture versus sham acupuncture
Liu et al. [28]	2009	E	HS	28	2	EA	GB37, KI8	Puncturing at GB37 versus puncturing at K18
Hui et al. [25]	2009	E	HS	48	3	MA	LI4, ST36, LV3	Acupuncture versus superficial tactile stimulation
Liu et al. [43]	2009	C	HS	21	2	MA	ST36	Puncturing at nonacupoints versus puncturing at ST36
Long et al. [44]	2009	C	HS	17	1	MA	ST36	Baseline versus after acupuncture
Zyloney et al. [45]	2010	E	HS	48	4	EA	LI3, LI4	Acupuncture versus sham acupuncture
Qiu et al. [46]	2010	E	HS	38	2	MA	LV3	Female versus male
Ren et al. [32]	2010	E	HS	36	3	MA	PC6, PC7, GB37	Puncturing at PC6 versus puncturing at PC7 versus puncturing at GB37
Hui et al. [47]	2010	E	HS	37	3	MA	LI4, ST36, LV3	Acupuncture versus sham acupuncture
Liu et al. [48]	2011	E	HS	14	2	MA	ST36	Acupuncture versus sham acupuncture
Feng et al. [49]	2011	E	HS	36	3	MA	PC6, PC7, GB37	Puncturing at PC6 versus puncturing at PC7 versus puncturing at GB37
Feng et al. [50]	2011	E	HS	36	3	MA	PC6, PC7, GB37	Puncturing at PC6 versus puncturing at PC7 versus puncturing at GB37
Feng et al. [12]	2011	E	HS	14	2	MA	ST36	Acupuncture versus sham acupuncture
Ye et al. [51]	2011	C	HS	10	1	MA	EX-UE7; (Yaotongdian)	Baseline versus after acupuncture
Ye et al. [51]	2011	C	LIDP, HS	20 (10 HS)	2	MA	EX-UE7; (Yaotongdian)	Baseline versus after acupuncture; LIDP patients versus HS
Ye et al. [52]	2011	C	LIDP	10	1	MA	EX-UE7; (Yaotongdian)	Baseline versus after acupuncture
Li et al. [53]	2011	C	HS	9	1	MA	ST36	Baseline versus after acupuncture
Fang et al. [54]	2011	C	HS	21	1	EA	RN12	Baseline versus after acupuncture
Zhong et al. [55]	2012	E	HS	12	2	MA	GB40, KI3	Baseline versus after acupuncture; puncturing at GB40 versus puncturing at KI3
You et al. [56]	2012	E	HS	28	2	MA	ST36	Acupuncture versus sham acupuncture
Jiang et al. [57]	2012	E	HS	40	2	TEAS		TEAS versus intermittent minimal TEAS
Fang et al. [29]	2012	E	HS	21	2	EA	CV4, CV12	Puncturing at CV4 versus puncturing at CV12
Feng et al. [11]	2012	E	MCI	24	2	MA	KI3	Baseline versus after acupuncture
Li et al. [38]	2012	C	Chronic sciatica, HS	20 (10 HS)	2	EA	GB30, BL40, BL25, BL23, BL57	Chronic sciatica patients versus HS
Zhao et al. [58]	2012	C	HS	20	1	MA	LI4	Baseline versus after acupuncture
Yi et al. [37]	2012	C	Depression, HS	39 (13 HS)	3	MA	LV3	HS versus puncturing at nonacupoints in depressed patients versus puncturing at LV3 in depressed patients
Fang et al. [59]	2012	C	HS	47	3	MA	LV3	Puncturing at LV3 with deqi versus puncturing at LV3 with deqi mixed with sharp pain versus superficial tactile stimulation at LV3
Dai et al. [60]	2012	C	HS	16	1	MA	SP6	Puncturing at nonacupoints versus puncturing at SP6
Zhang et al. [31]	2013	E	HS	12	1	EA	GV20, EX-HN3	5 min versus 15 min after acupuncture
You et al. [27]	2013	E	HS	28	2	MA	ST36	Acupuncture versus sham acupuncture
Jiang et al. [17]	2013	E	HS	18	4	MA, EA, TEAS	ST36	MA versus EA versus TEAS versus sensory stimulation
Dong et al. [61]	2013	E	HS	32	2	NA	NA	Acupuncturist versus nonacupuncturist
Chen et al. [34]	2013	E	MCI	24	2	MA	KI4	Baseline versus after acupuncture
Chen et al. [35]	2013	E	Primary hypertension	30	2	MA	GV20,GV23, EX-HN1 (Sishencong), LI4, ST36, SP6, LR3	Baseline versus after acupuncture
Chen et al. [62]	2013	C	MCI	6	1	MA	DU26	Baseline versus after acupuncture

E: English; C: Chinese; HS: healthy subjects; CTS: carpal tunnel syndrome; MCI: mild cognitive impairment; LIDP: lumbar intervertebral disc protrusion; MA: manual acupuncture; EA: electro-acupuncture; TEAS: transcutanclus electrical acupoint stimulation.