Evidence-Based Complementary and Alternative Medicine

Research Article

Preclinical Safety of the Root Extract of Polygala tenuifolia Willdenow in Sprague-Dawley Rats and Beagle Dogs

Table 3

Incidence of clinical signs of female beagle dogs orally treated with Polygala tenuifolia extracts in single dose oral toxicity study.
Sex: female
DaySigns observedGroup
01,0002,000
0-1 (0.5 hours)Appears normal 2/2*2/20/2
Vomiting (severe)0/20/22/2
0–2 (1 hour)Appears normal 2/21/22/2
Vomiting (moderate)0/21/20/2
0–3 (2 hours)Appears normal 2/22/22/2
0–4 (3 hours)Appears normal 2/22/22/2
0–5 (4 hours)Appears normal 2/22/22/2
0–6 (5 hours)Appears normal 2/22/22/2
0–7 (6 hours)Appears normal 2/22/22/2
1Appears normal 1/22/20/2
Vomiting (food)1/20/20/2
2Appears normal 2/22/22/2
3Appears normal 2/22/22/2
4Appears normal 2/22/22/2
5Appears normal 2/22/22/2
6Appears normal2/22/22/2
7Vomiting (food)2/22/22/2
8Appears normal2/22/22/2
9Appears normal2/22/22/2
10Appears normal2/22/22/2
11Appears normal2/22/22/2
12Appears normal2/22/22/2
13Appears normal2/22/22/2
14Appears normal2/22/22/2
Number of animals with the sign/number of animals examined.