Preclinical Safety of the Root Extract of Polygala tenuifolia Willdenow in Sprague-Dawley Rats and Beagle Dogs
Table 8
Hematological values (mean ± standard deviation) of male rats in the subchronic oral toxicity study of the root of Polygala tenuifolia.
Parameter
Dose (mg/kg/day)
0
360
600
1,000
WBC (103/L)
9.83 ± 2.83
8.19 ± 1.29
8.91 ± 2.14
9.40 ± 1.32
RBC (106/L)
8.75 ± 0.31
8.81 ± 0.24
8.69 ± 0.33
8.65 ± 0.29
Hemoglobin (g/dL)
15.7 ± 0.5
15.7 ± 0.4
15.4 ± 0.3
15.3 ± 0.5
Hematocrit (%)
46.0 ± 1.4
45.5 ± 1.0
45.0 ± 1.0
44.9 ± 1.5
MCV (fL)
52.5 ± 1.6
51.7 ± 1.3
51.8 ± 1.6
52.0 ± 1.4
MCH (pg)
17.9 ± 0.5
17.8 ± 0.5
17.8 ± 0.4
17.7 ± 0.4
MCHC (g/L)
34.1 ± 0.3
34.5 ± 0.4
34.4 ± 0.3
34.1 ± 0.5
RDW (%)
12.0 ± 0.3
11.8 ± 0.3
11.8 ± 0.2
11.6 ± 0.3**
HDW (g/dL)
2.35 ± 0.05
2.35 ± 0.08
2.35 ± 0.09
2.32 ± 0.12
Platelet (103/L)
1061.1 ± 106.5
1030.4 ± 59.9
1043.8 ± 38.4
1103.0 ± 64.7
MPV (fL)
7.0 ± 0.7
6.8 ± 0.7
6.8 ± 0.7
7.0 ± 0.7
Reticulocyte (%)
2.00 ± 0.28
1.84 ± 0.31
1.90 ± 0.31
1.83 ± 0.18
10
10
10
10
WBC: white blood cell count; RBC: red blood cell count; MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin concentration; MCHC; mean corpuscular hemoglobin concentration; RDW: red cell distribution width; HDW: hemoglobin distribution width; MPV: mean platelet volume. **Significant difference at P < 0.01 compared with the vehicle-treated group.
