Table 3: Antihypertensive effect produced by losartan (10 mg/kg) and fractions (50 mg/kg) obtained from SeRAce, on pretreated mice with AG II (1.0  g/kg, i.v. ).

Treatment Systolic BP mmHg Diastolic BP mmHg

Vehicle 127.51 ± 3.24 61.14 ± 6.74
AG II 146.40 ± 3.01 95.90 ± 8.01
R2 133.98 ± 15.86 86.3 ± 14.86
R5 122.61 ± 16.43 84.5 ± 18.08
R6 132.38 ± 17.87 93.03 ± 20.83
R8 138.01 ± 14.84 93.63 ± 13.98
R11 119.45 ± 19.85 82.07 ± 16.23
R14 109.21 ± 13.94*68.88 ± 12.10*
R17 109.09 ± 8.73*71.66 ± 14.53*
R20 122.55 ± 13.15 77.71 ± 10.97
Losartan 119.50 ± 11.73 77.45 ± 12.41

Data are presented as means ± SD with   . ANOVA and post hoc Bonferroni test. is with respect to the negative control (AG II 1.0  g/kg).