In Vitro and In Vivo Characterization of the New Analgesic Combination Beta-Caryophyllene and Docosahexaenoic Acid

Figure 7

Formalin test: time course of formalin-induced flexing (AD), licking (BE), and jerking (CF) of the injected paw during FT2 and FT3 in the OIL (■), BCP (□), and BCP+DHA (▼) groups. ANOVA showed that BCP and BCP+DHA administration significantly reduced the formalin-induced responses, in particular, during FT2. Values are means ± SEM. See Section 3 for details. ^∗∗𝑃<0.001 versus BCP, ^∗𝑃<0.05 versus BCP, ^##𝑃<0.001 versus BCP+DHA, and ^#𝑃<0.05 versus BCP+DHA.