Treatment of Acute Lymphoblastic Leukemia from Traditional Chinese Medicine

Figure 5

Docking pose of MTX and TCM candidates with DHFR for (a), (b), (c), (d), and (e). Docking pose of MTX-PGs with TS for (f), (g), (h), (i), and (j). TCM candidates are shown in cyan. The cofactors are shown in purple. In H-bond interactions, nitrogen atoms are shown in blue, hydrogen atoms are shown in gray, oxygen atoms are shown in magenta, hydrogen bonds are shown in red dotted line, pi bonds are shown in orange solid line. (a) MTX, (b) and (g) adenosine triphosphate, (c) and (h) manninotriose, (d) and (i) raffinose, (e) and (j) stachyose, and (f) MTX-PGs.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)

(j)