Evidence-Based Complementary and Alternative Medicine / 2014 / Article / Tab 1

Research Article

Neurotrophic Signaling Factors in Brain Ischemia/Reperfusion Rats: Differential Modulation Pattern between Single-Time and Multiple Electroacupuncture Stimulation

Table 1

Differentiation changes (greater than 2.0-fold) of gene expression in MCAO rats at day 1 (Rep 1 d) and day 7 (Rep 7 d) of reperfusion in ischemia (isc) or ischemia plus EA (EA) group. Sham, sham-operation group.
(a) List of genes which had similar expression change tendency at the two reperfusion time points

Functional groupsGeneRep 1 d (isc/sham)Rep 7 d (isc/sham)

Apoptosis-related genesApaf1↓↓
Tp53↓↓

Neuropeptides and receptorsNpff
Nmbr

Inflammatory-related factorsIl10
Il10ra
Il6
Tac1

Signaling moleculesFos
Jun↑↑
Stat2

Neurotrophins and receptorsCntfr↓↓
Gmfg↓↓
Hcrtr1
Snt-2↓↓
Vgf

(b) List of genes which had different expression change pattern at the two time points

Functional groupsGeneRep 1 d (isc/sham)Rep 7 d (isc/sham)

Apoptosis-related genesBax
Tnfrsf6↓↓
Hspb1

Growth factors and receptorsPtn
Tgfa

Neuropeptides and receptorsNpy
Npy1r
Npy2r↓↓

Inflammatory-related factorsCxcr4↓↓
Cx3cr1
Il1b
Il1r1
Il6r
Lifr

Signaling moleculesAtf2
Myc
Elk1
Ets1
Mef2c
Rps6ka6 ↓↓
Stat1
Stat4
Stat5a
Stat5b↓↓

Neurotrophins and receptorsArtn
Bdnf
Gfra1
Gfra2↓↓↓
Gfra3↓↓
Gmfb
Cd200r1↓↓
Mt3
Ngfb
Ngfr
Nrg1
Nrg4
Ntrk2
Nr1i2
Tro
Ucn