Neurotrophic Signaling Factors in Brain Ischemia/Reperfusion Rats: Differential Modulation Pattern between Single-Time and Multiple Electroacupuncture Stimulation
Table 1
Differentiation changes (greater than 2.0-fold) of gene expression in MCAO rats at day 1 (Rep 1 d) and day 7 (Rep 7 d) of reperfusion in ischemia (isc) or ischemia plus EA (EA) group. Sham, sham-operation group.
(a) List of genes which had similar expression change tendency at the two reperfusion time points
Functional groups
Gene
Rep 1 d (isc/sham)
Rep 7 d (isc/sham)
Apoptosis-related genes
Apaf1
↓↓
↓
Tp53
↓↓
↓
Neuropeptides and receptors
Npff
↓
↓
Nmbr
↓
↓
Inflammatory-related factors
Il10
↑
↑
Il10ra
↓
↓
Il6
↑
↑
Tac1
↓
↓
Signaling molecules
Fos
↓
↓
Jun
↑↑
↑
Stat2
↓
↓
Neurotrophins and receptors
Cntfr
↓↓
↓
Gmfg
↓
↓↓
Hcrtr1
↑
↑
Snt-2
↓
↓↓
Vgf
↓
↓
(b) List of genes which had different expression change pattern at the two time points
