Evidence-Based Complementary and Alternative Medicine

Research Article

Neurotrophic Signaling Factors in Brain Ischemia/Reperfusion Rats: Differential Modulation Pattern between Single-Time and Multiple Electroacupuncture Stimulation

Table 2

Differentiation changes (greater than 2.0-fold) of gene expression in MCAO rats under single-time EA stimulation (EA Rep 1 d) or multiple EA stimulation (EA Rep 7 d) when compared with ischemia group (isc).
(a) List of genes which had similar expression change tendency at day 1 and day 7 of reperfusion
Functional groupsGeneRep 1 d (EA/isc)Rep 7 d (EA/isc)
Apoptosis-related genesApaf1↑↑↑
Tnfrsf6↑↑
Hspb1↑↑↑
Tp53↑↑
Growth factors and receptorsFgf2↑↑↑
Neurotrophins and receptorsCntfr↑↑
Gfra3↑↑↑
Gmfg↑↑↑
Cd200r1↑↑
Pnoc↓↓↓
Vgf↑↑
Stat5a↑↑↑
(b) List of genes which had different expression change pattern at the two time points
Functional groupsGeneRep 1 d (EA/isc)Rep 7 d (EA/isc)
Apoptosis-related genesBax↓—
Growth factors and receptorsPtn↑—
Tgfb1↓—
Fgfr1—↑
Neuropeptides and receptorsNpff—↑
Nmbr↑—
Npy1r↑—
Npy2r↑—
Npy6r—↓
Inflammatory-related factorsCd40—↑
Cxcr4↑↑—
Il10—↑
Il1b↓↑
Lifr↓↑
Tac1↑↑↓
Il6st—↑
Signaling moleculesFos—↑
Jun↓↑↑
Myc↓↑
Ets1↑—
Mef2c↑—
Rps6ka6↑↑—
Stat1—↓
Stat2—↓↓
Stat5b↑↑—
Stat6↑—
Neurotrophins and receptorsArtn↑—
Adcyap1r1—↑
Bdnf—↑
Cbln1↑—
Cntf↑—
Crh—↑
Crhbp↑—
Gfra1↑—
Gfra2↑↑—
Gmfb—↑
Ngfb↑—
Ngfr—↑
Nrg1↑↓
Penk—↓
Snt-2↑—
Tro—↓
Ucn—↑
Zfp110↑↑—