Evidence-Based Complementary and Alternative Medicine / 2014 / Article / Tab 2

Research Article

Neurotrophic Signaling Factors in Brain Ischemia/Reperfusion Rats: Differential Modulation Pattern between Single-Time and Multiple Electroacupuncture Stimulation

Table 2

Differentiation changes (greater than 2.0-fold) of gene expression in MCAO rats under single-time EA stimulation (EA Rep 1 d) or multiple EA stimulation (EA Rep 7 d) when compared with ischemia group (isc).
(a) List of genes which had similar expression change tendency at day 1 and day 7 of reperfusion

Functional groupsGeneRep 1 d (EA/isc)Rep 7 d (EA/isc)

Apoptosis-related genesApaf1↑↑
Tnfrsf6
Hspb1↑↑
Tp53

Growth factors and receptorsFgf2↑↑

Neurotrophins and receptorsCntfr
Gfra3↑↑
Gmfg↑↑
Cd200r1
Pnoc↓↓
Vgf
Stat5a↑↑

(b) List of genes which had different expression change pattern at the two time points

Functional groupsGeneRep 1 d (EA/isc)Rep 7 d (EA/isc)

Apoptosis-related genesBax

Growth factors and receptorsPtn
Tgfb1
Fgfr1

Neuropeptides and receptorsNpff
Nmbr
Npy1r
Npy2r
Npy6r

Inflammatory-related factorsCd40
Cxcr4↑↑
Il10
Il1b
Lifr
Tac1↑↑
Il6st

Signaling moleculesFos
Jun↑↑
Myc
Ets1
Mef2c
Rps6ka6↑↑
Stat1
Stat2↓↓
Stat5b↑↑
Stat6

Neurotrophins and receptorsArtn
Adcyap1r1
Bdnf
Cbln1
Cntf
Crh
Crhbp
Gfra1
Gfra2↑↑
Gmfb
Ngfb
Ngfr
Nrg1
Penk
Snt-2
Tro
Ucn
Zfp110↑↑