Tetramethylpyrazine Protects against Hydrogen Peroxide-Provoked Endothelial Dysfunction in Isolated Rat Aortic Rings: Implications for Antioxidant Therapy of Vascular Diseases

<table>Tetramethylpyrazine (TMP) does not rescue endothelium-dependent relaxation (EDR) through actions on endothelial nitric oxide synthase (eNOS) expression. Rat aortic rings were subjected to various experimental conditions (phenylephrine (Phe); Phe plus acetylcholine (ACh); hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>, 200 <i>μ</i>M); TMP (10 nM) plus H<sub>2</sub>O<sub>2</sub>; losartan (1 <i>μ</i>M) plus H<sub>2</sub>O<sub>2</sub>; or removal of the endothelium). The bar graph shows the ratio of the eNOS integrated density value (IDV) to the glyceraldehyde 3-phosphate dehydrogenase (GAPDH) IDV for each experimental condition. Data represent the mean ± the standard error of the mean (SEM) of 5–8 independent experiments.</table>

Evidence-Based Complementary and Alternative Medicine

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Figure 3: Tetramethylpyrazine Protects against Hydrogen Peroxide-Provoked Endothelial Dysfunction in Isolated Rat Aortic Rings: Implications for Antioxidant Therapy of Vascular Diseases 

Figure 3 | Tetramethylpyrazine Protects against Hydrogen Peroxide-Provoked Endothelial Dysfunction in Isolated Rat Aortic Rings: Implications for Antioxidant Therapy of Vascular Diseases 