Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 637528, 8 pages
http://dx.doi.org/10.1155/2014/637528
Research Article

Elemene Injection Induced Autophagy Protects Human Hepatoma Cancer Cells from Starvation and Undergoing Apoptosis

1Institute of First Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210046, China
2Department of Oncology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210021, China
3Laboratory of Cellular and Molecular Biology, Jiangsu Province Institute of Traditional Chinese Medicine, 100 Shizi Street, Hongshan Road, Nanjing, Jiangsu 210028, China
4Oncology Center of Chinese, 81 Hospital of PLA, Nanjing, Jiangsu 210002, China

Received 20 May 2014; Accepted 23 May 2014; Published 24 July 2014

Academic Editor: Peng Cao

Copyright © 2014 Yan Lin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. M. Llovet, A. Burroughs, and J. Bruix, “Hepatocellular carcinoma,” The Lancet, vol. 362, no. 9399, pp. 1907–1917, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Hidalgo and S. G. Eckhardt, “Development of matrix metalloproteinase inhibitors in cancer therapy,” Journal of the National Cancer Institute, vol. 93, pp. 178–193, 2001. View at Google Scholar
  3. D. L. Vaux, “A boom time for necrobiology,” Current Biology, vol. 3, pp. 877–878, 1993. View at Publisher · View at Google Scholar
  4. K. Wang, X. Yin, D. T. Chao, C. L. Milliman, and S. J. Korsmeyer, “BID: a novel BH3 domain-only death agonist,” Genes and Development, vol. 10, no. 22, pp. 2859–2869, 1996. View at Publisher · View at Google Scholar · View at Scopus
  5. I. Tanida, “Autophagosome formation and molecular mechanism of autophagy,” Antioxidants and Redox Signaling, vol. 14, no. 11, pp. 2201–2214, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Li, X. Zhao, L. Chen et al., “Safety and pharmacokinetics of novel selective vascular endothelial growth factor receptor-2 inhibitor YN968D1 in patients with advanced malignancies,” BMC Cancer, vol. 10, article 529, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Jemal, F. Bray, M. M. Center, J. Ferlay, E. Ward, and D. Forman, “Global cancer statistics,” CA: A Cancer Journal for Clinicians, vol. 61, no. 2, pp. 69–90, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. J. F. Perz, G. L. Armstrong, L. A. Farrington, Y. J. F. Hutin, and B. P. Bell, “The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide,” Journal of Hepatology, vol. 45, no. 4, pp. 529–538, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. Z. Y. Tang, “Hepatocellular carcinoma surgery—review of the past and prospects for the 21st century,” Journal of Surgical Oncology, vol. 91, pp. 95–96, 2005. View at Google Scholar
  10. E. H. Park, Y. J. Kim, N. Yamabe et al., “Stereospecific anticancer effects of ginsenoside Rg3 epimers isolated from heat-processed American ginseng on human gastric cancer cell,” Journal of Ginseng Research, vol. 38, no. 1, pp. 22–27, 2014. View at Publisher · View at Google Scholar
  11. S. I. Jang, Y. W. Lee, C. K. Cho, H. S. Yoo, and J. H. Jang, “Identification of target genes involved in the antiproliferative effect of enzyme-modified ginseng extract in HepG2 hepatocarcinoma cell,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 502568, 8 pages, 2013. View at Publisher · View at Google Scholar
  12. X. Chen, Y. Wang, H. Luo et al., “β-elemene acts as an antitumor factor and downregulates the expression of survivin, Bcl-xL and Mta-1,” Molecular Medicine Reports, vol. 6, no. 5, pp. 989–995, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. X. Lu, Y. Wang, H. Luo et al., “β-elemene inhibits the proliferation of T24 bladder carcinoma cells through upregulation of the expression of Smad4,” Molecular Medicine Reports, vol. 7, no. 2, pp. 513–518, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. H. Shi, L. Liu, J. Geng, Y. Zhou, and L. Chen, “beta-Elemene inhibits the metastasis of B16F10 melanoma cells by downregulation of the expression of uPA, uPAR, MMP-2, and MMP-9,” Melanoma Research, vol. 24, pp. 99–107, 2014. View at Google Scholar
  15. H. Q. Hua, S. K. Qin, J. H. Wang, and H. Chen, “Study on effect of arsenic trioxide on adhesion and invasion of human hepatocarcinoma cells in vitro,” Chinese journal of integrated traditional and Western medicine, vol. 24, no. 10, pp. 922–925, 2004. View at Google Scholar · View at Scopus
  16. N. Y. Lin, C. Beyer, A. Gießl et al., “Autophagy regulates TNFα-mediated joint destruction in experimental arthritis,” Annals of the Rheumatic Diseases, vol. 72, no. 5, pp. 761–768, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. K. S. Choi, “Autophagy and cancer,” Experimental & Molecular Medicine, vol. 44, pp. 109–120, 2012. View at Publisher · View at Google Scholar
  18. R. Mathew, C. M. Karp, B. Beaudoin et al., “Autophagy suppresses tumorigenesis through elimination of p62,” Cell, vol. 137, pp. 1062–1075, 2009. View at Google Scholar · View at Scopus
  19. A. Herman-Antosiewicz, D. E. Johnson, and S. V. Singh, “Sulforaphane causes autophagy to inhibit release of cytochrome c and apoptosis in human prostate cancer cells,” Cancer Research, vol. 66, no. 11, pp. 5828–5835, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. C. Ji, L. Zhang, Y. Cheng et al., “Induction of autophagy contributes to crizotinib resistance in ALK-positive lung cancer,” Cancer Biology & Therapy, vol. 15, no. 5, pp. 570–577, 2014. View at Publisher · View at Google Scholar
  21. J. Wang and G. S. Wu, “Role of autophagy in cisplatin resistance in ovarian cancer cells,” The Journal of Biological Chemistry, vol. 289, no. 24, pp. 17163–17173, 2014. View at Google Scholar
  22. M. K. Sannigrahi, V. Singh, R. Sharma, N. K. Panda, and M. Khullar, “Role of autophagy in head and neck cancer and therapeutic resistance,” Oral Diseases, 2014. View at Publisher · View at Google Scholar