Tanshinone IIA Downregulates HMGB1 and TLR4 Expression in a Spinal Nerve Ligation Model of Neuropathic Pain
Figure 1
Tanshinone IIA alleviates the neuropathic pain. (a) PWT decreased in the SNL rats ( versus sham group). After Tan IIA treatment, the PWT increased ( < 0.05 versus model group). Data are shown as the mean ± S. D. (b) PWL decreased in the SNL rats ( versus sham group). After Tan IIA treatment, the PWL increased ( versus model group). Data are shown as the mean ± S.D. L: lumbar. SNL: spinal nerve ligation. PWT: paw withdrawal threshold (g). PWL: paw withdrawal latency. S.D: standard deviation.
