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Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 642128, 5 pages
http://dx.doi.org/10.1155/2014/642128
Research Article

History and Experience: A Survey of Traditional Chinese Medicine Treatment for Alzheimer's Disease

1Key Laboratory of Traditional Chinese Medicine Resource and Compound Prescription of the Ministry of Education, Hubei University of Chinese Medicine, Wuhan 430065, China
2Key Laboratory of Senile Dementia (Xing Nao Yi Zhi), State Administration of Traditional Chinese Medicine of the People’s Republic of China, Hubei University of Chinese Medicine, Wuhan 430065, China

Received 16 September 2013; Revised 4 December 2013; Accepted 17 December 2013; Published 29 January 2014

Academic Editor: Chun Fu Wu

Copyright © 2014 Ping Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Solomon, M. Kivipelto, and H. Soininen, “Prevention of Alzheimer's disease: moving backward through the life span,” Journal of Alzheimer’s Disease, vol. 33, supplement 1, pp. 465–469, 2013. View at Google Scholar
  2. Y. Huang and L. Mucke, “Alzheimer mechanisms and therapeutic strategies,” Cell, vol. 148, no. 6, pp. 1204–1222, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. J. E. Galvin and C. H. Sadowsky, “Pratical guidelines for the recognition and diagnosis of dementia,” Journal of the American Board of Family Medicine, vol. 25, no. 3, pp. 367–382, 2012. View at Google Scholar
  4. P. Martin, B. Renata, and F. Cleusa, World Alzheimer Report 2011: The Benefits of Early Diagnosis and Intervention, Alzheimer's Disease International, London, UK, 2011.
  5. J. Fantini and N. Yahi, “Molecular insights into amyloid regulation by membrane cholesterol and sphingolipids: common mechanisms in neurodegenerative diseases,” Expert Reviews in Molecular Medicine, vol. 12, p. e27, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. H. Q. Lin, M. T. Ho, L. S. Lau, K. K. Wong, P. C. Shaw, and D. C. C. Wan, “Anti-acetylcholinesterase activities of traditional Chinese medicine for treating Alzheimer's disease,” Chemico-Biological Interactions, vol. 175, no. 1–3, pp. 352–354, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. J. de la Torre, G. Aliev, G. Perry, T. E. Finucane, M. A. Meyer, and J. L. Cummings, “Drug therapy in Alzheimer's disease,” The New England Journal of Medicine, vol. 351, no. 18, pp. 1911–1913, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. T. Y. Wu, C. P. Chen, and T. R. Jinn, “Traditional Chinese medicines and alzheimer's disease,” Taiwanese Journal of Obstetrics and Gynecology, vol. 50, no. 2, pp. 131–135, 2011. View at Google Scholar
  9. J. Gao, Y. Inagaki, X. Li et al., “Research progress on natural products from traditional Chinese medicine in treatment of Alzheimer's disease,” Drug Discoveries & Therapeutics, vol. 7, no. 2, pp. 46–57, 2013. View at Google Scholar
  10. H. Yan, L. Li, and X. C. Tang, “Treating senile dementia with traditional Chinese medicine,” Clinical Interventions in Aging, vol. 2, no. 2, pp. 201–208, 2007. View at Google Scholar · View at Scopus
  11. Y.-C. Miao, J.-Z. Tian, J. Shi, and M. Mao, “Effects of Chinese medicine for tonifying the kidney and resolving phlegm and blood stasis in treating patients with amnestic mild cognitive impairment: a randomized, double-blind and parallel-controlled trial,” Zhong Xi Yi Jie He Xue Bao, vol. 10, no. 4, pp. 390–397, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. Z. K. Sun, H. Q. Yang, and S. D. Chen, “Traditional Chinese medicine: a promising candidate for the treatment of Alzheimer's disease,” Translational Neurodegeneration, vol. 2, no. 1, pp. 6–8, 2013. View at Google Scholar
  13. J. B. Zhang, Jing Yue Quan Shu, Peoples Medical Publishing House, Beijing, China, 2007.
  14. S. D. Chen, Bianzheng Lu, Traditional Chinese Medicine Press, Beijing, China, 2010.
  15. C. P. Yao, Huangdi Neijing, Chinese Publishing House, 2010.
  16. E. K. Perry, A. T. Pickering, W. W. Wang, P. J. Houghton, and N. S. L. Perry, “Medicinal plants and Alzheimer's disease: from ethnobotany to phytotherapy,” Journal of Pharmacy and Pharmacology, vol. 51, no. 5, pp. 527–534, 1999. View at Publisher · View at Google Scholar · View at Scopus
  17. L. L. D. Santos-Neto, M. A. de Vilhena Toledo, P. Medeiros-Souza, and G. A. de Souza, “The use of herbal medicine in Alzheimer's disease—a systematic review,” Evidence-Based Complementary and Alternative Medicine, vol. 3, no. 4, pp. 441–445, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. Z. Lin, J. Gu, J. Xiu, T. Mi, J. Dong, and J. K. Tiwari, “Traditional Chinese medicine for senile dementia,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 692621, 13 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. D. P. Yuen, X. F. Qiu, P. Wang et al., “Deficiency of kidney and febility of marrow, blockage of brain vollateral: basic pathogenesis of Alzheimer's disease,” Zhonghua Zhongyiyao Zazhi, vol. 23, no. 8, pp. 732–734, 2008. View at Google Scholar
  20. N. Egashira, K. Iwasaki, Y. Akiyoshi et al., “Protective effect of Toki-shakuyaku-san on amyloid β25-35- induced neuronal damage in cultured rat cortical neurons,” Phytotherapy Research, vol. 19, no. 5, pp. 450–453, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. Z.-Y. Hu, G. Liu, H. Yuan et al., “Danggui-Shaoyao-San and its active fraction JD-30 improve Aβ-induced spatial recognition deficits in mice,” Journal of Ethnopharmacology, vol. 128, no. 2, pp. 365–372, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. T. Itoh, S. Michijiri, S. Murai et al., “Regulatory effect of danggui-shaoyao-san on central cholinergic nervous system dysfunction in mice,” The American Journal of Chinese Medicine, vol. 24, no. 3-4, pp. 205–217, 1996. View at Google Scholar · View at Scopus
  23. J. Kou, D. Zhu, and Y. Yan, “Neuroprotective effects of the aqueous extract of the Chinese medicine Danggui-Shaoyao-san on aged mice,” Journal of Ethnopharmacology, vol. 97, no. 2, pp. 313–318, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. Y.-F. Qian, H. Wang, W.-B. Yao, and X.-D. Gao, “Aqueous extract of the Chinese medicine, Danggui-Shaoyao-San, inhibits apoptosis in hydrogen peroxide-induced PC12 cells by preventing cytochrome c release and inactivating of caspase cascade,” Cell Biology International, vol. 32, no. 2, pp. 304–311, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Maruyama, N. Tomita, K. Iwasaki et al., “Benefits of combining donepezil plus traditional Japanese herbal medicine on cognition and brain perfusion in Alzheimer's disease: a 12-week observer-blind, donepezil monotherapy controlled trial,” Journal of the American Geriatrics Society, vol. 54, no. 5, pp. 869–871, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. S. de Caires and V. Steenkamp, “Use of Yokukansan (TJ-54) in the treatment of neurological disorders: a review,” Phytotherapy Research, vol. 24, no. 9, pp. 1265–1270, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Tabuchi, T. Yamaguchi, S. Iizuka, S. Imamura, Y. Ikarashi, and Y. Kase, “Ameliorative effects of yokukansan, a traditional Japanese medicine, on learning and non-cognitive disturbances in the Tg2576 mouse model of Alzheimer's disease,” Journal of Ethnopharmacology, vol. 122, no. 1, pp. 157–162, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. A. Takeda, H. Itoh, H. Tamano, M. Yuzurihara, and N. Oku, “Suppressive effect of Yokukansan on excessive release of glutamate and aspatate in the hippocampus of zinc-deficient rats,” Nutritional Neuroscience, vol. 11, no. 1, pp. 41–46, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Tateno, W. Ukai, S. Saito, T. Ono, E. Hashimoto, and T. Saito, “Neuroprotective effects of Yi-Gan San against beta amyloid-induced cytotoxicity on rat cortical neurons,” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 32, no. 7, pp. 1704–1707, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. T. Yabe, K. Torizuka, and H. Yamada, “Effects of Kampo medicines on choline acetyltransferase activity in rat embryo septal cultures,” Journal of Traditional Chinese Medicine, vol. 12, pp. 54–60, 1995. View at Google Scholar
  31. Z. Kawakami, H. Kanno, T. Ueki et al., “Neuroprotective effects of yokukansan, a traditional japanese medicine, on glutamate-mediated excitotoxicity in cultured cells,” Neuroscience, vol. 159, no. 4, pp. 1397–1407, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. P. Wang, L. Liu, and X. M. Shi, “The influence of Xinnao Yizhi prescription on IAAs in hippocampi, cortex and striate body of brain of SAM-P/10,” Zhong Guo Shi Yan Fang Ji Xue Za Zhi, vol. 7, no. 4, pp. 24–27, 2001. View at Google Scholar
  33. P. Wang, L. Liu, and X. M. Shi, “The influence of Jiawei Wendan prescription on EAAs in hippocampi, cortex and striate body of brain of SAM-P/10,” Zhong Guo Yi Yuan Yao Xue Za Zhi, vol. 22, no. 11, pp. 645–648, 2002. View at Google Scholar
  34. P. Wang, H. Hu, and M. W. Kong, “The effect and potential mechanism of replenishing kidney-essence removing phlegm therapy on GSK-3β on hyperphos-phorylation for AD rat model,” Zhong Hua Zhong Yi Yao Xue Kan, vol. 27, no. 9, pp. 1845–1847, 2009. View at Google Scholar
  35. P. Wang, H. Hu, and M. W. Kong, “Effects and function mechanism of replenishing kidney-essence and removing phlegm therapy on behavior in the rats of AD,” Cheng Du Xi Xue Yuan Xue Bao, vol. 4, no. 2, pp. 79–84, 2009. View at Google Scholar
  36. P. Liu, L. Zhao, J.-Z. Xiang, and S.-L. Zhang, “Modified Wendan decoction can attenuate neurotoxic action associated with Alzheimer's disease,” Evidence-Based Complementary and Alternative Medicine, vol. 6, no. 3, pp. 325–330, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. P. Wang, H. Hu, and M. W. Kong, “Effect and potential mechanism of replenishing the kidney and eliminating phlegm therapy on CaMKII- αactivities of AD rat model,” Zhong Hua Zhong Yi Yao Za Zhi, vol. 25, no. 5, pp. 786–788, 2010. View at Google Scholar
  38. P. Liu and P. Wang, “Clinical study on effect of replenishing kidney-essence, removing phlegm and promoting mentality therapy on treating alzheimer’s disease,” Journal of Traditional Chinese Medicine, vol. 33, no. 4, pp. 449–454, 2013. View at Google Scholar
  39. G. Peter Echkert, “Traditional used plants against cognitive decline and Alzheimer disease,” Frontiers in Pharmacology, vol. 1, pp. 1–10, 2010. View at Google Scholar
  40. L. Yu, S. W. Lin, R. Q. Zhou et al., “Chinese herbal medicine for patients with mild to moderate Alzheimer’s disease based on syndrome differentiation: a randomized controlled trial,” Zhong Xi Yi Jie He Xue Bao, vol. 10, no. 7, pp. 76–82, 2012. View at Google Scholar
  41. D. J. Cao, X. Y. Li, F. Guo et al., “In vivo effects of Radix Polygalae on learning memory and the hippocampal long term potentiation in AD model rats,” Shi Jie Zhong Xi Yi Jie He Za Zhi, vol. 5, no. 8, pp. 661–664, 2010. View at Google Scholar
  42. J. Wen, B. N. Yang, C. Q. Xue et al., “The study of polygala tenuifolia willd promote neurogenesis in Alzheimer’s disease model mice,” Shen Jing Jie Pou Za Zhi, vol. 26, no. 2, pp. 145–149, 2010. View at Google Scholar
  43. C. N. Shi, X. G. Li, Q. S. Xu et al., “Effects of polygala tenuifolia extracts on learning and memory abilities in Alzeimer’s disease model mice,” Journal Apoplexy & Nervous Disease, vol. 28, no. 7, pp. 620–622, 2011. View at Google Scholar
  44. Z. Lin, Z. Xiao, D. Zhu, Y. Yan, B. Yu, and Q. Wang, “Aqueous extracts of FBD, a Chinese herb formula composed of Poria cocos, Atractylodes macrocephala, and Angelica sinensis reverse scopolamine induced memory deficit in ICR mice,” Pharmaceutical Biology, vol. 47, no. 5, pp. 396–401, 2009. View at Publisher · View at Google Scholar · View at Scopus
  45. S. M. Tian, Y. X. Ma, L. Z. Sun et al., “Effects of different fractions of Acori graminei rhizoma extracts on learning and memory abilities in Aβ-induced Alzheimer disease mice,” Zhong Guo Bing Li Sheng Li Za Zhi, vol. 28, no. 1, pp. 159–162, 2012. View at Google Scholar
  46. Y. Jiang, Y. Q. Fang, and Y. P. He, “Protective effect of combination of effective components in Acorus tatarinowii on PC12 cell injuryed by beta amyloid protein,” Traditional Chinese Drug Research and Clinical Pharmacology, vol. 17, no. 5, pp. 335–338, 2006. View at Google Scholar
  47. X. Y. Yang, “The effects of refined polygonum multiflorum thunb polysaccharide on learning memory and the activities of enzymes in the brain for the experimental mice with dementia,” Yao Xue Jin Zhan, vol. 29, no. 12, pp. 557–559, 2005. View at Google Scholar
  48. Q. C. Zhu, C. Q. Ren, L. Bao et al., “Effect of polygonum multiflorum thumb on learning and memory capacity in mice with AD,” Heilongjiang Yi Yao Ke Xue, vol. 34, no. 3, pp. 8–9, 2011. View at Google Scholar
  49. H. Jiang, X. Luo, and D. Bai, “Progress in clinical, pharmacological, chemical and structural biological studies of huperzine A: a drug of traditional Chinese medicine origin for the treatment of Alzheimer's disease,” Current Medicinal Chemistry, vol. 10, no. 21, pp. 2231–2252, 2003. View at Publisher · View at Google Scholar · View at Scopus
  50. H. Y. Zhang and X. C. Tang, “Neuroprotective effects of huperzine A: new therapeutic targets for neurodegenerative disease,” Trends in Pharmacological Sciences, vol. 27, no. 12, pp. 619–625, 2006. View at Publisher · View at Google Scholar · View at Scopus
  51. Y.-H. Zhang, X.-Y. Zhao, Y. Wang, X.-Q. Chen, H.-H. Yang, and G.-Y. Hu, “Spermidine antagonizes the inhibitory effect of huperzine A on [3H]dizocilpine (MK-801) binding in synaptic membrane of rat cerebral cortex,” Neuroscience Letters, vol. 319, no. 2, pp. 107–110, 2002. View at Publisher · View at Google Scholar · View at Scopus
  52. Y.-C. Miao, J.-Z. Tian, J. Shi et al., “Correlation between cognitive functions and syndromes of traditional Chinese medicine in amnestic mild cognitive impairment,” Journal of Chinese Integrative Medicine, vol. 7, no. 3, pp. 205–211, 2009. View at Publisher · View at Google Scholar · View at Scopus