Lingonberry (Vaccinium vitis-idaea L.) Exhibits Antidiabetic Activities in a Mouse Model of Diet-Induced Obesity
Figure 3
V. vitis-idaea activates Akt and AMPK pathways and tends to decrease acetyl p53 content in soleus muscle of DIO mice. Samples of soleus muscles were obtained from CHOW, DIO control, and DIO mice fed with V. vitis-idaea (125, 250, and 500 mg/Kg) and analyzed by immunoblotting. (a) Representative blots for each group are shown for samples probed with p-Akt, p-AMPK, acetyl p53, and β-actin as loading control. Data are expressed as mean ± SEM from 12 animals in each experimental group for (b) p-Akt (Ser 473)/β-actin, (c) p-AMPKα (Thr 172)/β-actin, and (d) Acetyl p53 (Lys 379)/β-actin. * indicates a value ≤ 0.05 significantly different from CHOW group, and † indicates a value ≤ 0.05 significantly different from DIO control group.
