Lingonberry (Vaccinium vitis-idaea L.) Exhibits Antidiabetic Activities in a Mouse Model of Diet-Induced Obesity
Figure 5
V. vitis-idaea treatment activates Akt and AMPK pathway but does not increase PPAR-α content in the liver of DIO mice. Samples of liver tissue from CHOW, control DIO, and DIO mice fed with V. vitis-idaea (125, 250, and 500 mg/Kg) were homogenized and analysed by immunoblotting. (a) Representative immunoblots of samples probed with p-AMPK, p-Akt, PPARα, and β-actin as loading control are shown. Data are expressed as mean ± SEM from 12 animals per experimental group for (b) p-AMPK/ β -actin, (c) p-Akt/ β -actin, and (d) PPARα / β -actin andlevels were quantified using densitometry. † indicates a value < 0.05 significantly different from DIO control group.
