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Evidence-Based Complementary and Alternative Medicine
Volume 2014 (2014), Article ID 648308, 18 pages
http://dx.doi.org/10.1155/2014/648308
Review Article

Herbal Medicines for the Treatment of Nonalcoholic Steatohepatitis: Current Scenario and Future Prospects

1Division of Gastroenterology and Hepatology, Department of Medicine, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA
2Division of Phytotherapeutics and Metabolic Endocrinology, Department of Zoology, Faculty of Science, The M. S. University of Baroda, Vadodara, Gujarat 390002, India
3School of Science and Health, University of Western Sydney, Sydney, NSW 2751, Australia
4NICM, Centre for Complementary Medicine Research, University of Western Sydney, Sydney, NSW 2751, Australia

Received 17 March 2014; Accepted 30 April 2014; Published 3 June 2014

Academic Editor: Menaka C. Thounaojam

Copyright © 2014 Ravirajsinh Jadeja et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. N. Chalasani, Z. Younossi, J. E. Lavine et al., “The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association,” Hepatology, vol. 55, no. 6, pp. 2005–2023, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. P. Paschos and K. Paletas, “Non alcoholic fatty liver disease and metabolic syndrome,” Hippokratia, vol. 13, no. 1, pp. 9–19, 2009. View at Google Scholar · View at Scopus
  3. J. Ludwig, T. R. Viggiano, D. B. McGill, and B. J. Ott, “Nonalcoholic steatohepatitis. Mayo Clinic experiences with a hitherto unnamed disease,” Mayo Clinic Proceedings, vol. 55, no. 7, pp. 434–438, 1980. View at Google Scholar · View at Scopus
  4. M. D. Beaton, “Current treatment options for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis,” Canadian Journal of Gastroenterology, vol. 26, no. 6, pp. 353–357, 2012. View at Google Scholar · View at Scopus
  5. M. Durazzo, P. Belci, A. Collo, E. Grisoglio, and S. Bo, “Focus on therapeutic strategies of nonalcoholic fatty liver disease,” International Journal of Hepatology, vol. 2012, Article ID 464706, 9 pages, 2012. View at Publisher · View at Google Scholar
  6. B. Lam and Z. M. Younossi, “Review: treatment options for nonalcoholic fatty liver disease,” Therapeutic Advances in Gastroenterology, vol. 3, no. 2, pp. 121–137, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Mouzaki and J. Allard, “Non-alcoholic steatohepatitis: the therapeutic challenge of a global epidemic,” Annals of Gastroenterology, vol. 25, no. 3, pp. 207–217, 2012. View at Google Scholar · View at Scopus
  8. M. C. Thounaojam, R. N. Jadeja, R. V. Devkar, and A. V. Ramachandran, “Non-alcoholic steatohepatitis: an overview including treatments with herbals as alternative therapeutics,” Journal of Applied Biomedicine, vol. 10, no. 3, pp. 119–136, 2012. View at Google Scholar
  9. B. A. Neuschwander-Tetri and S. H. Caldwell, “Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference,” Hepatology, vol. 37, no. 5, pp. 1202–1219, 2003. View at Publisher · View at Google Scholar · View at Scopus
  10. K. Nakajima, “Multidisciplinary pharmacotherapeutic options for nonalcoholic fatty liver disease,” International Journal of Hepatology, vol. 2012, Article ID 950693, 13 pages, 2012. View at Publisher · View at Google Scholar
  11. C. P. Day and O. F. W. James, “Steatohepatitis: a tale of two “Hits”,” Gastroenterology, vol. 114, no. 4 I, pp. 842–845, 1998. View at Publisher · View at Google Scholar · View at Scopus
  12. H. Cortez-Pinto, M. C. de Moura, and C. P. Day, “Non-alcoholic steatohepatitis: from cell biology to clinical practice,” Journal of Hepatology, vol. 44, no. 1, pp. 197–208, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. H. Tilg and A. R. Moschen, “Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis,” Hepatology, vol. 52, no. 5, pp. 1836–1846, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Bongiovanni and F. Tordato, “Steatohepatitis in HIV-infected subjects: pathogenesis, clinical impact and implications in clinical management,” Current HIV Research, vol. 5, no. 5, pp. 490–498, 2007. View at Google Scholar · View at Scopus
  15. Y. Takahashi, Y. Soejima, and T. Fukusato, “Animal models of nonalcoholic fatty liver disease/ nonalcoholic steatohepatitis,” World Journal of Gastroenterology, vol. 18, no. 19, pp. 2300–2308, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Ninomiya, Y. Kondo, and T. Shimosegawa, “Murine models of nonalcoholic fatty liver disease and steatohepatitis,” ISRN Hepatology, vol. 2013, Article ID 237870, 7 pages, 2013. View at Publisher · View at Google Scholar
  17. K. Nakajima, “Multidisciplinary pharmacotherapeutic options for nonalcoholic fatty liver disease,” International Journal of Hepatology, vol. 2012, Article ID 950693, 13 pages, 2012. View at Publisher · View at Google Scholar
  18. N. C. Chavez-Tapia, F. I. Tellez-Avila, T. Barrientos-Gutierrez, N. Mendez-Sanchez, J. Lizardi-Cervera, and M. Uribe, “Bariatric surgery for non-alcoholic steatohepatitis in obese patients,” Cochrane Database of Systematic Reviews, no. 1, Article ID CD007340, 2010. View at Google Scholar · View at Scopus
  19. R. N. Jadeja, M. C. Thounaojam, D. S. Dandekar, R. V. Devkar, and A. V. Ramachandran, “Clerodendron glandulosum.Coleb extract ameliorates high fat diet/fatty acid induced lipotoxicity in experimental models of non-alcoholic steatohepatitis,” Food and Chemical Toxicology, vol. 48, no. 12, pp. 3424–3431, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. C. Jaya and C. V. Anuradha, “Cissus quadrangularis stem alleviates insulin resistance, oxidative injury and fatty liver disease in rats fed high fat plus fructose diet,” Food and Chemical Toxicology, vol. 48, no. 8-9, pp. 2021–2029, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. Z.-J. Xu, J.-G. Fan, X.-D. Ding, L. Qiao, and G.-L. Wang, “Characterization of high-fat, diet-induced, non-alcoholic steatohepatitis with fibrosis in rats,” Digestive Diseases and Sciences, vol. 55, no. 4, pp. 931–940, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. H. S. Oz, T. S. Chen, and M. Neuman, “Methionine deficiency and hepatic injury in a dietary steatohepatitis model,” Digestive Diseases and Sciences, vol. 53, no. 3, pp. 767–776, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. Z. Li, S. Yang, H. Lin et al., “Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease,” Hepatology, vol. 37, no. 2, pp. 343–350, 2003. View at Publisher · View at Google Scholar · View at Scopus
  24. C. Z. Larter and M. M. Yeh, “Animal models of NASH: getting both pathology and metabolic context right,” Journal of Gastroenterology and Hepatology, vol. 23, no. 11, pp. 1635–1648, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. H. Nakayama, S. Otabe, T. Ueno et al., “Transgenic mice expressing nuclear sterol regulatory element-binding protein 1c in adipose tissue exhibit liver histology similar to nonalcoholic steatohepatitis,” Metabolism, vol. 56, no. 4, pp. 470–475, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. K. Okumura, K. Ikejima, K. Kon et al., “Exacerbation of dietary steatohepatitis and fibrosis in obese, diabetic KK-Ay mice,” Hepatology Research, vol. 36, no. 3, pp. 217–228, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. Y. Horie, A. Suzuki, E. Kataoka et al., “Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas,” Journal of Clinical Investigation, vol. 113, no. 12, pp. 1774–1783, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. P. Nagarajan, M. Jerald Mahesh Kumar, R. Venkatesan, S. S. Majundar, and R. C. Juyal, “Genetically modified mouse models for the study of nonalcoholic fatty liver disease,” World Journal of Gastroenterology, vol. 18, no. 11, pp. 1141–1153, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. S. C. Lu, L. Alvarez, Z.-Z. Huang et al., “Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation,” Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 10, pp. 5560–5565, 2001. View at Publisher · View at Google Scholar · View at Scopus
  30. T. Asano, K. Watanabe, N. Kubota et al., “Adiponectin knockout mice on high fat diet develop fibrosing steatohepatitis,” Journal of Gastroenterology and Hepatology, vol. 24, no. 10, pp. 1669–1676, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. S. Wueest, R. A. Rapold, D. M. Schumann et al., “Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice,” Journal of Clinical Investigation, vol. 120, no. 1, pp. 191–202, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. N. Ouchi, A. Higuchi, K. Ohashi et al., “Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity,” Science, vol. 329, no. 5990, pp. 454–457, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. C. P. M. S. de Oliveira, V. M. R. de Lima, F. I. Simplicio et al., “Prevention and reversion of nonalcoholic steatohepatitis in OB/OB mice by S-nitroso-N-acetylcysteine treatment,” Journal of the American College of Nutrition, vol. 27, no. 2, pp. 299–305, 2008. View at Google Scholar · View at Scopus
  34. M. E. Rinella, M. S. Elias, R. R. Smolak, T. Fu, J. Borensztajn, and R. M. Green, “Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet,” Journal of Lipid Research, vol. 49, no. 5, pp. 1068–1076, 2008. View at Publisher · View at Google Scholar · View at Scopus
  35. M. Carmiel-Haggai, A. I. Cederbaum, and N. Nieto, “A high-fat diet leads to the progression of non-alcoholic fatty liver disease in obese rats,” FASEB Journal, vol. 19, no. 1, pp. 136–138, 2005. View at Publisher · View at Google Scholar · View at Scopus
  36. J. M. Schattenberg, Y. Wang, R. Singh, R. M. Rigoli, and M. J. Czaja, “Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling,” Journal of Biological Chemistry, vol. 280, no. 11, pp. 9887–9894, 2005. View at Publisher · View at Google Scholar · View at Scopus
  37. F. T. Wunderlich, T. Luedde, S. Singer et al., “Hepatic NF-κB essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 4, pp. 1297–1302, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. J.-H. Fu, H.-S. Sun, Y. Wang, W.-Q. Zheng, Z.-Y. Shi, and Q.-J. Wang, “The effects of a fat- and sugar-enriched diet and chronic stress on nonalcoholic fatty liver disease in male wistar rats,” Digestive Diseases and Sciences, vol. 55, no. 8, pp. 2227–2236, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. L. Bujanda, E. Hijona, M. Larzabal et al., “Resveratrol inhibits nonalcoholic fatty liver disease in rats,” BMC Gastroenterology, vol. 8, article 40, 2008. View at Publisher · View at Google Scholar · View at Scopus
  40. N. Rafiq and Z. M. Younossi, “Effects of weight loss on nonalcoholic fatty liver disease,” Seminars in Liver Disease, vol. 28, no. 4, pp. 427–433, 2008. View at Publisher · View at Google Scholar · View at Scopus
  41. S. A. Al-Busafi, P. Wong, P. Ghali, and M. Deschenes, “Antioxidant therapy in nonalcoholic steatohepatitis,” Hepatitis Research and Treatment, vol. 2012, Article ID 947575, 8 pages, 2012. View at Publisher · View at Google Scholar
  42. A. Duseja, “Therapy of nonalcoholic steatohepatitis (NASH)—antioxidants and cytoprotective agents,” Tropical Gastroenterology, vol. 32, supplement 1, pp. S33–S37, 2011. View at Google Scholar
  43. L. L. Stein, M. H. Dong, and R. Loomba, “Insulin sensitizers in nonalcoholic fatty liver disease and steatohepatitis: current status,” Advances in Therapy, vol. 26, no. 10, pp. 893–907, 2009. View at Publisher · View at Google Scholar · View at Scopus
  44. W. Nseir, J. Mograbi, and M. Ghali, “Lipid-lowering agents in nonalcoholic fatty liver disease and steatohepatitis: human studies,” Digestive Diseases and Sciences, vol. 57, no. 7, pp. 1773–1781, 2012. View at Publisher · View at Google Scholar · View at Scopus
  45. H.-X. Guo, D.-H. Liu, Y. Ma et al., “Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet,” Acta Pharmacologica Sinica, vol. 30, no. 11, pp. 1505–1512, 2009. View at Publisher · View at Google Scholar · View at Scopus
  46. T. Murase, K. Misawa, Y. Minegishi et al., “Coffee polyphenols suppress diet-induced body fat accumulation by downregulating SREBP-1c and related molecules in C57BL/6J mice,” The American Journal of Physiology—Endocrinology and Metabolism, vol. 300, no. 1, pp. E122–E133, 2011. View at Publisher · View at Google Scholar · View at Scopus
  47. E. Kim, Y. Choi, J. Jang, and T. Park, “Carvacrol protects against hepatic steatosis in mice fed a high-fat diet by enhancing SIRT1-AMPK signaling,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 290104, 10 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  48. I. A. Leclercq, G. C. Farrell, C. Sempoux, A. D. Peña, and Y. Horsmans, “Curcumin inhibits NF-κB activation and reduces the severity of experimental steatohepatitis in mice,” Journal of Hepatology, vol. 41, no. 6, pp. 926–934, 2004. View at Publisher · View at Google Scholar · View at Scopus
  49. F. Vizzutti, A. Provenzano, S. Galastri et al., “Curcumin limits the fibrogenic evolution of experimental steatohepatitis,” Laboratory Investigation, vol. 90, no. 1, pp. 104–115, 2010. View at Publisher · View at Google Scholar · View at Scopus
  50. J. M. Li, Y. C. Li, L. D. Kong, and Q. H. Hu, “Curcumin inhibits hepatic protein-tyrosine phosphatase 1B and prevents hypertriglyceridemia and hepatic steatosis in fructose-fed rats,” Hepatology, vol. 51, no. 5, pp. 1555–1566, 2010. View at Google Scholar
  51. M. Bose, J. D. Lambert, J. Ju, K. R. Reuhl, S. A. Shapses, and C. S. Yang, “The major green tea polyphenol, (-)-epigallocatechin-3-gallate, inhibits obesity, metabolic syndrome, and fatty liver disease in high-fat-fed mice,” Journal of Nutrition, vol. 138, no. 9, pp. 1677–1683, 2008. View at Google Scholar · View at Scopus
  52. T. Ueno, T. Torimura, T. Nakamura et al., “Epigallocatechin-3-gallate improves nonalcoholic steatohepatitis model mice expressing nuclear sterol regulatory element binding protein-1c in adipose tissue,” International Journal of Molecular Medicine, vol. 24, no. 1, pp. 17–22, 2009. View at Publisher · View at Google Scholar · View at Scopus
  53. I. H. Bahcecioglu, N. Kuzu, K. Metin et al., “Lycopene prevents development of steatohepatitis in experimental nonalcoholic steatohepatitis model induced by high-fat diet,” Veterinary Medicine International, vol. 2010, Article ID 262179, 8 pages, 2010. View at Publisher · View at Google Scholar · View at Scopus
  54. C. J. Chang, T.-F. Tzeng, S.-S. Liou, Y.-S. Chang, and I.-M. Liu, “Myricetin increases hepatic peroxisome proliferator-activated receptor protein expression and decreases plasma lipids and adiposity in rats,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 787152, 11 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  55. K. W. Cho, Y. O. Kim, J. E. Andrade, J. R. Burgess, and Y.-C. Kim, “Dietary naringenin increases hepatic peroxisome proliferators-activated receptor α protein expression and decreases plasma triglyceride and adiposity in rats,” European Journal of Nutrition, vol. 50, no. 2, pp. 81–88, 2011. View at Publisher · View at Google Scholar · View at Scopus
  56. S. Park, Y. Choi, S.-J. Um, S. K. Yoon, and T. Park, “Oleuropein attenuates hepatic steatosis induced by high-fat diet in mice,” Journal of Hepatology, vol. 54, no. 5, pp. 984–993, 2011. View at Publisher · View at Google Scholar · View at Scopus
  57. H. Jwa, Y. Choi, U.-H. Park, S.-J. Um, S. K. Yoon, and T. Park, “Piperine, an LXRα antagonist, protects against hepatic steatosis and improves insulin signaling in mice fed a high-fat diet,” Biochemical Pharmacology, vol. 84, no. 11, pp. 1501–1510, 2012. View at Publisher · View at Google Scholar · View at Scopus
  58. E. Marcolin, B. San-Miguel, D. Vallejo et al., “Quercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis,” Journal of Nutrition, vol. 142, no. 10, pp. 1821–1828, 2012. View at Publisher · View at Google Scholar · View at Scopus
  59. É. Marcolin, L. F. Forgiarini, G. Rodrigues et al., “Quercetin decreases liver damage in mice with non-alcoholic steatohepatitis,” Basic and Clinical Pharmacology and Toxicology, vol. 112, no. 6, pp. 385–391, 2013. View at Publisher · View at Google Scholar · View at Scopus
  60. H.-Z. Ying, Y.-H. Liu, B. Yu, Z.-Y. Wang, J.-N. Zang, and C.-H. Yu, “Dietary quercetin ameliorates nonalcoholic steatohepatitis induced by a high-fat diet in gerbils,” Food and Chemical Toxicology, vol. 52, pp. 53–60, 2013. View at Publisher · View at Google Scholar · View at Scopus
  61. J. Shang, L.-L. Chen, F.-X. Xiao, H. Sun, H.-C. Ding, and H. Xiao, “Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase,” Acta Pharmacologica Sinica, vol. 29, no. 6, pp. 698–706, 2008. View at Publisher · View at Google Scholar · View at Scopus
  62. S. K. Panchal, H. Poudyal, T. V. Arumugam, and L. Brown, “Rutin attenuates metabolic changes, nonalcoholic steatohepatitis, and cardiovascular remodeling in high-carbohydrate, high-fat diet-fed rats,” Journal of Nutrition, vol. 141, no. 6, pp. 1062–1069, 2011. View at Publisher · View at Google Scholar · View at Scopus
  63. M. Kim, S.-G. Yang, J. M. Kim, J.-W. Lee, Y. S. Kim, and J. I. Lee, “Silymarin suppresses hepatic stellate cell activation in a dietary rat model of non-alcoholic steatohepatitis: analysis of isolated hepatic stellate cells,” International Journal of Molecular Medicine, vol. 30, no. 3, pp. 473–479, 2012. View at Publisher · View at Google Scholar · View at Scopus
  64. X.-Y. Luo, T. Takahara, J. Hou et al., “Theaflavin attenuates ischemia-reperfusion injury in a mouse fatty liver model,” Biochemical and Biophysical Research Communications, vol. 417, no. 1, pp. 287–293, 2012. View at Publisher · View at Google Scholar · View at Scopus
  65. H.-Y. Song, Z.-M. Mao, L.-L. Yang et al., “Dangfei liganning capsules attenuate the susceptibility of rat nonalcoholic fatty liver to carbon tetrachloride toxicity,” Journal of Traditional Chinese Medicine, vol. 31, no. 4, pp. 327–333, 2011. View at Google Scholar · View at Scopus
  66. G. Ji, J.-G. Fan, J.-J. Chen et al., “Effectiveness of Danning Tablet in patients with non-alcoholic fatty liver of damp-heat syndrome type: a multicenter randomized controlled trial,” Zhong Xi Yi Jie He Xue Bao, vol. 6, no. 2, pp. 128–133, 2008. View at Publisher · View at Google Scholar · View at Scopus
  67. Y.-H. Jia, R.-Q. Wang, H.-M. Mi et al., “Fuzheng Huayu recipe prevents nutritional fibrosing steatohepatitis in mice,” Lipids in Health and Disease, vol. 11, article 45, 2012. View at Publisher · View at Google Scholar · View at Scopus
  68. M. Fujimoto, K. Tsuneyama, M. Kainuma et al., “Evidence-based efficacy of kampo formulas in a model of non alcoholic fatty liver,” Experimental Biology and Medicine, vol. 233, no. 3, pp. 328–337, 2008. View at Publisher · View at Google Scholar · View at Scopus
  69. M. Suriyavathana Vedanarayanan and N. Krishnan, “Ayurvedic formulation of Liv-Pro-08 reduces nonalcoholic fatty liver disease in rats fed with high-fat diet,” Journal of Acupuncture and Meridian Studies, vol. 4, no. 4, pp. 236–241, 2011. View at Publisher · View at Google Scholar · View at Scopus
  70. S.-Y. Yang, N.-J. Zhao, X.-J. Li, H.-J. Zhang, K.-J. Chen, and C.-D. Li, “Ping-tang recipe improves insulin resistance and attenuates hepatic steatosis in high-fat diet-induced obese rats,” Chinese Journal of Integrative Medicine, vol. 18, no. 4, pp. 262–268, 2012. View at Publisher · View at Google Scholar · View at Scopus
  71. L. Li, X.-J. Zhang, Y. Lan, L. Xu, X.-Z. Zhang, and H.-H. Wang, “Treatment of non-alcoholic fatty liver disease by Qianggan capsule,” Chinese Journal of Integrative Medicine, vol. 16, no. 1, pp. 23–27, 2010. View at Publisher · View at Google Scholar · View at Scopus
  72. H.-S. Li, Q. Feng, L.-L. Xu, S.-D. Chen, X.-M. Li, and Y.-Y. Hu, “Effects of Qushi Huayu Decoction in prevention and treatment of fatty liver in rats based on adiponection-free fatty acid pathway,” Zhong Xi Yi Jie He Xue Bao, vol. 7, no. 6, pp. 546–551, 2009. View at Publisher · View at Google Scholar · View at Scopus
  73. H. Zhang, Q. Feng, H.-S. Li et al., “Effects of Qushi Huayu Decoction on cathepsin B and tumor necrosis factor-α expression in rats with non-alcoholic steatohepatitis,” Zhong Xi Yi Jie He Xue Bao, vol. 6, no. 9, pp. 928–933, 2008. View at Publisher · View at Google Scholar · View at Scopus
  74. J. S. Kang, W. K. Lee, W. K. Yoon et al., “A combination of grape extract, green tea extract and l -carnitine improves high-fat diet-induced obesity, hyperlipidemia and non-alcoholic fatty liver disease in mice,” Phytotherapy Research, vol. 25, no. 12, pp. 1789–1795, 2011. View at Publisher · View at Google Scholar · View at Scopus
  75. J. S. Kang, W. K. Lee, C. W. Lee et al., “Improvement of high-fat diet-induced obesity by a mixture of red grape extract, soy isoflavone and l-carnitine: implications in cardiovascular and non-alcoholic fatty liver diseases,” Food and Chemical Toxicology, vol. 49, no. 9, pp. 2453–2458, 2011. View at Publisher · View at Google Scholar · View at Scopus
  76. Q. Zhang, Y. Zhao, D.-B. Zhang, and L.-J. Sun, “Effect of Sinai San decoction on the development of non-alcoholic steatohepatitis in rats,” World Journal of Gastroenterology, vol. 11, no. 9, pp. 1392–1395, 2005. View at Google Scholar · View at Scopus
  77. C.-L. Gu, Y.-K. Zhang, Y.-X. Fu, S.-F. Yang, and X.-Q. Li, “Effect of Tiaozhi Yanggan Decoction in treating patients with non-alcoholic fatty liver,” Chinese Journal of Integrative Medicine, vol. 13, no. 4, pp. 275–279, 2007. View at Publisher · View at Google Scholar · View at Scopus
  78. S.-D. Chen, Y. Fan, and W.-J. Xu, “Effects of Yinchenhao Decoction for non-alcoholic steatohepatitis in rats and study of the mechanism,” Journal of Traditional Chinese Medicine, vol. 31, no. 3, pp. 220–223, 2011. View at Google Scholar · View at Scopus
  79. N. Chande, M. Laidlaw, P. Adams, and P. Marotta, “Yo Jyo Hen Shi Ko (YHK) improves transaminases in nonalcoholic steatohepatitis (NASH): a randomized pilot study,” Digestive Diseases and Sciences, vol. 51, no. 7, pp. 1183–1189, 2006. View at Publisher · View at Google Scholar · View at Scopus
  80. I. Vermaak, A. M. Viljoen, and J. H. Hamman, “Natural products in anti-obesity therapy,” Natural Product Reports, vol. 28, no. 9, pp. 1493–1533, 2011. View at Publisher · View at Google Scholar · View at Scopus
  81. T.-P. Liu, C.-S. Lee, S.-S. Liou, I.-M. Liu, and J.-T. Cheng, “Improvement of insulin resistance by Acanthopanax senticosus root in fructose-rich chow-fed rats,” Clinical and Experimental Pharmacology and Physiology, vol. 32, no. 8, pp. 649–654, 2005. View at Publisher · View at Google Scholar · View at Scopus
  82. J. Fu, J. Fu, J. Yuan et al., “Anti-diabetic activities of Acanthopanax senticosus polysaccharide (ASP) in combination with metformin,” International Journal of Biological Macromolecules, vol. 50, no. 3, pp. 619–623, 2012. View at Publisher · View at Google Scholar · View at Scopus
  83. Y.-S. Cha, S.-J. Rhee, and Y.-R. Heo, “Acanthopanax senticosus extract prepared from cultured cells decreases adiposity and obesity indices in C57BL/6J mice fed a high fat diet,” Journal of Medicinal Food, vol. 7, no. 4, pp. 422–429, 2004. View at Google Scholar · View at Scopus
  84. S. H. Park, S. G. Lee, S. K. Kang, and S. H. Chung, “Acanthopanax senticosus reverses fatty liver disease and hyperglycemia in ob/ob mice,” Archives of Pharmacal Research, vol. 29, no. 9, pp. 768–776, 2006. View at Google Scholar · View at Scopus
  85. X. Hong, H. Tang, L. Wu, and A. Li, “Protective effects of the Alisma orientalis extract on the experimental nonalcoholic fatty liver disease,” Journal of Pharmacy and Pharmacology, vol. 58, no. 10, pp. 1391–1398, 2006. View at Publisher · View at Google Scholar · View at Scopus
  86. X. B. Yang and Z. M. Huang, “Effects of rhizome alismatis extract on blood glucose in normal and diabetes,” Pharmacology and Clinics of Chinese Materia Medica, vol. 14, pp. 19–23, 2004. View at Google Scholar
  87. X.-B. Yang, Z.-M. Huang, W.-B. Cao et al., “Effects of rhizome alismatis extract on blood biochemical indices and insulin in hyperglycemic mice,” Chinese Journal of Clinical Rehabilitation, vol. 8, no. 6, pp. 1196–1197, 2004. View at Google Scholar · View at Scopus
  88. R. S. Bruno, C. E. Dugan, J. A. Smyth, D. A. DiNatale, and S. I. Koo, “Green tea extract protects leptin-deficient, spontaneously obese mice from hepatic steatosis and injury,” Journal of Nutrition, vol. 138, no. 2, pp. 323–331, 2008. View at Google Scholar · View at Scopus
  89. N. Kuzu, I. H. Bahcecioglu, A. F. Dagli, I. H. Ozercan, B. Ustündag, and K. Sahin, “Epigallocatechin gallate attenuates experimental non-alcoholic steatohepatitis induced by high fat diet,” Journal of Gastroenterology and Hepatology, vol. 23, no. 8, pp. e465–e470, 2008. View at Publisher · View at Google Scholar · View at Scopus
  90. K. Nakamoto, F. Takayama, M. Mankura et al., “Beneficial effects of fermented green tea extract in a rat model of non-alcoholic steatohepatitis,” Journal of Clinical Biochemistry and Nutrition, vol. 44, no. 3, pp. 239–246, 2009. View at Publisher · View at Google Scholar · View at Scopus
  91. A. H. M. Viswanatha Swamy, R. V. Kulkarni, A. H. M. Thippeswamy, B. C. Koti, and A. Gore, “Evaluation of hepatoprotective activity of Cissus quadrangularis stem extract against isoniazid-induced liver damage in rats,” Indian Journal of Pharmacology, vol. 42, no. 6, pp. 397–400, 2010. View at Publisher · View at Google Scholar · View at Scopus
  92. M. K. Sen and B. K. Dash, “A review on phytochemical and pharmacological aspects of Cissus quadrangularis L,” International Journal of Green Pharmacy, vol. 6, no. 3, pp. 169–173, 2012. View at Publisher · View at Google Scholar · View at Scopus
  93. J. Chidambaram and A. Carani Venkatraman, “Cissus quadrangularis stem alleviates insulin resistance, oxidative injury and fatty liver disease in rats fed high fat plus fructose diet,” Food and Chemical Toxicology, vol. 48, no. 8-9, pp. 2021–2029, 2010. View at Publisher · View at Google Scholar · View at Scopus
  94. J. Chidambaram, V. Vetriselvi, and A. Carani Venkatraman, “Inflammatory responses in liver induced by high fat plus fructose diet: therapeutic potential of cissus quadrangularis stem,” International Journal Of Biological and Medical Research, vol. 1, no. 4, pp. 120–124, 2010. View at Google Scholar
  95. R. N. Jadeja, M. C. Thounaojam, T. B. Singh, R. V. Devkar, and A. Ramachandran, “Traditional uses, phytochemistry and pharmacology of Clerodendron glandulosum Coleb—a review,” Asian Pacific Journal of Tropical Medicine, vol. 5, no. 1, pp. 1–6, 2012. View at Google Scholar · View at Scopus
  96. C. P. Kala, “Ethnomedicinal botany of the Apatani in the Eastern Himalayan region of India,” Journal of Ethnobiology and Ethnomedicine, vol. 1, article 11, 2005. View at Publisher · View at Google Scholar · View at Scopus
  97. S. Deb, A. Arunachalam, and A. K. Das, “Indigenous knowledge of Nyishi tribes on traditional agroforestry systems,” Indian Journal of Traditional Knowledge, vol. 8, no. 1, pp. 41–46, 2009. View at Google Scholar · View at Scopus
  98. J. Purkayastha, S. C. Nath, and M. Islam, “Ethnobotany of medicinal plants from Dibru-Saikhowa Biosphere Reserve of Northeast India,” Fitoterapia, vol. 76, no. 1, pp. 121–127, 2005. View at Publisher · View at Google Scholar · View at Scopus
  99. R. N. Jadeja, M. C. Thounaojam, R. V. Devkar, and A. V. Ramachandran, “A preliminary study on hypolipidemic effect of aqueous leaf extract of Clerodendron glandulosum.Coleb,” International Journal of Green Pharmacy, vol. 3, no. 4, pp. 285–289, 2009. View at Publisher · View at Google Scholar · View at Scopus
  100. R. N. Jadeja, M. C. Thounaojam, R. V. Devkar, and A. V. Ramachandran, “Clerodendron glandulosum Coleb., Verbenaceae, ameliorates high fat diet-induced alteration in lipid and cholesterol metabolism in rats,” Brazilian Journal of Pharmacognosy, vol. 20, no. 1, pp. 117–123, 2010. View at Google Scholar · View at Scopus
  101. R. N. Jadeja, M. C. Thounaojam, V. B. Patel, R. V. Devkar, and A. V. Ramachandran, “Protective effect of Clerodendron glandulosum extract against experimentally induced metabolic syndrome in rats,” Pharmaceutical Biology, vol. 48, no. 12, pp. 1312–1319, 2010. View at Publisher · View at Google Scholar · View at Scopus
  102. R. N. Jadeja, M. C. Thounaojam, U. V. Ramani, R. V. Devkar, and A. V. Ramachandran, “Anti-obesity potential of Clerodendron glandulosum.Coleb leaf aqueous extract,” Journal of Ethnopharmacology, vol. 135, no. 2, pp. 338–343, 2011. View at Publisher · View at Google Scholar · View at Scopus
  103. R. N. Jadeja, M. C. Thounaojam, S. V. Jadav et al., “Toxicological evaluation and hepatoprotective potential of Clerodendron glandulosum.Coleb leaf extract,” Human and Experimental Toxicology, vol. 30, no. 1, pp. 63–70, 2011. View at Publisher · View at Google Scholar · View at Scopus
  104. “Curcuma longa (turmeric). Monograph,” Alternative Medicine Review, vol. 6, supplement, pp. S62–S66, 2001.
  105. L. Alappat and A. B. Awad, “Curcumin and obesity: evidence and mechanisms,” Nutrition Reviews, vol. 68, no. 12, pp. 729–738, 2010. View at Publisher · View at Google Scholar · View at Scopus
  106. R. Kaffashi Elahi, “Preventive effects of turmeric (Curcuma longa Linn.) powder on hepatic steatosis in the rats fed with high fat diet,” Life Science Journal, vol. 9, no. 4, pp. 5462–5468, 2012. View at Google Scholar · View at Scopus
  107. W.-F. Yiu, P.-L. Kwan, C.-Y. Wong et al., “Attenuation of fatty liver and prevention of hypercholesterolemia by extract of Curcuma longa through regulating the expression of CYP7A1, LDL-receptor, HO-1, and HMG-CoA reductase,” Journal of Food Science, vol. 76, no. 3, pp. H80–H89, 2011. View at Publisher · View at Google Scholar · View at Scopus
  108. A. Asai and T. Miyazawa, “Dietary curcuminoids prevent high-fat diet-induced lipid accumulation in rat liver and epididymal adipose tissue,” Journal of Nutrition, vol. 131, no. 11, pp. 2932–2935, 2001. View at Google Scholar · View at Scopus
  109. I. A. Leclercq, G. C. Farrell, C. Sempoux, A. D. Peña, and Y. Horsmans, “Curcumin inhibits NF-κB activation and reduces the severity of experimental steatohepatitis in mice,” Journal of Hepatology, vol. 41, no. 6, pp. 926–934, 2004. View at Publisher · View at Google Scholar · View at Scopus
  110. J. Oh, O.-J. Min, H.-A. Kim, Y. J. Kim, H. Y. Baek, and D. Y. Rhyu, “Effect of Eriobotrya japonica on adipogenesis and body weight,” Journal of Applied Biological Chemistry, vol. 54, no. 3, pp. 382–387, 2011. View at Publisher · View at Google Scholar · View at Scopus
  111. K. Tanaka, S. Nishizono, N. Makino, S. Tamaru, O. Terai, and I. Ikeda, “Hypoglycemic activity of Eriobotrya japonica seeds in type 2 diabetic rats and mice,” Bioscience, Biotechnology and Biochemistry, vol. 72, no. 3, pp. 686–693, 2008. View at Publisher · View at Google Scholar · View at Scopus
  112. M. Singh, C. K. Jain, and A. Mathur, “Phyto-pharmacological potential of Ginkgo biloba: a review,” Journal of Pharmacy Research, vol. 5, no. 10, pp. 5028–5030, 2012. View at Google Scholar
  113. T. R. Cong W, J. Tian, J. Zhao, Q. Liu, and F. Ye, “EGb761, an extract of Ginkgo biloba leaves, reduces insulin resistance in a high-fat-fed mouse model,” Acta Pharmaceutica Sinica, vol. 1, no. 1, pp. 14–20, 2011. View at Google Scholar
  114. J. Xia, X. Zhang, X. Ye, J. Liu, L. Wang, and Y. Zhong, “Intervention study of Ginkgo biloba extract in rat model of lipid-induced insulin resistance,” Journal of Medicinal Plant Research, vol. 5, no. 27, pp. 6284–6290, 2011. View at Publisher · View at Google Scholar · View at Scopus
  115. S. D. Wang, Z. Q. Xie, J. Chen et al., “Inhibitory effect of ginkgo biloba extract on fatty liver: regulation of carnitine palmitoyltransferase 1a and fatty acid metabolism,” Journal of Digestive Diseases, vol. 13, no. 10, pp. 525–535, 2012. View at Publisher · View at Google Scholar · View at Scopus
  116. M. F. Elshal and K. O. Abulnaja, “Influence of defatted flaxseed diet on insulin sensitivity, vascular permeability and lipid profile in a rat model of type 2 diabetes mellitus,” Journal of Medicinal Plants Research, vol. 6, no. 11, pp. 2188–2193, 2012. View at Google Scholar
  117. Y. Rhee and A. Brunt, “Flaxseed supplementation improved insulin resistance in obese glucose intolerant people: a randomized crossover design,” Nutrition Journal, vol. 10, no. 1, article 44, 2011. View at Publisher · View at Google Scholar · View at Scopus
  118. S. Fukumitsu, K. Aida, H. Shimizu, and K. Toyoda, “Flaxseed lignan lowers blood cholesterol and decreases liver disease risk factors in moderately hypercholesterolemic men,” Nutrition Research, vol. 30, no. 7, pp. 441–446, 2010. View at Publisher · View at Google Scholar · View at Scopus
  119. M. Kristensen, M. G. Jensen, J. Aarestrup et al., “Flaxseed dietary fibers lower cholesterol and increase fecal fat excretion, but magnitude of effect depend on food type,” Nutrition & Metabolism, vol. 9, article 8, 2012. View at Publisher · View at Google Scholar · View at Scopus
  120. S.-F. Yang, J.-K. Tseng, Y.-Y. Chang, and Y.-C. Chen, “Flaxseed oil attenuates nonalcoholic fatty liver of hyperlipidemic hamsters,” Journal of Agricultural and Food Chemistry, vol. 57, no. 11, pp. 5078–5083, 2009. View at Publisher · View at Google Scholar · View at Scopus
  121. P. K. Mukherjee, D. Mukherjee, A. K. Maji, S. Rai, and M. Heinrich, “The sacred lotus (Nelumbo nucifera)—phytochemical and therapeutic profile,” Journal of Pharmacy and Pharmacology, vol. 61, no. 4, pp. 407–422, 2009. View at Publisher · View at Google Scholar · View at Scopus
  122. B. Xie, J. Wan, W. Q. Wang, C. Y. Shi, X. L. Hou, and J. G. Fang, “Nelumbo nucifera alkaloid inhibits 3T3-L1 preadipocyte differentiation and improves high-fat diet-induced obesity and body fat accumulation in rats,” Journal of Medicinal Plants Research, vol. 5, no. 10, pp. 2021–2028, 2011. View at Google Scholar · View at Scopus
  123. Y. Ono, E. Hattori, Y. Fukaya, S. Imai, and Y. Ohizumi, “Anti-obesity effect of Nelumbo nucifera leaves extract in mice and rats,” Journal of Ethnopharmacology, vol. 106, no. 2, pp. 238–244, 2006. View at Publisher · View at Google Scholar · View at Scopus
  124. C.-H. Wu, M.-Y. Yang, K.-C. Chan, P.-J. Chung, T.-T. Ou, and C.-J. Wang, “Improvement in high-fat diet-induced obesity and body fat accumulation by a nelumbo nucifera leaf flavonoid-rich extract in mice,” Journal of Agricultural and Food Chemistry, vol. 58, no. 11, pp. 7075–7081, 2010. View at Publisher · View at Google Scholar · View at Scopus
  125. Y. Tsuruta, K. Nagao, B. Shirouchi et al., “Effects of lotus root (the edible rhizome of nelumbo nucifera) on the deveolopment of non-alcoholic fatty liver disease in obese diabetic db/db mice,” Bioscience, Biotechnology and Biochemistry, vol. 76, no. 3, pp. 462–466, 2012. View at Publisher · View at Google Scholar · View at Scopus
  126. Y. Tsuruta, K. Nagao, S. Kai et al., “Polyphenolic extract of lotus root (edible rhizome of Nelumbo nucifera) alleviates hepatic steatosis in obese diabetic db/db mice,” Lipids in Health and Disease, vol. 10, article 202, 2011. View at Publisher · View at Google Scholar · View at Scopus
  127. R. Ghanbari, F. Anwar, K. M. Alkharfy, A.-H. Gilani, and N. Saari, “Valuable nutrients and functional bioactives in different parts of olive (Olea europaea L.)—a review,” International Journal of Molecular Sciences, vol. 13, no. 3, pp. 1291–1340, 2012. View at Publisher · View at Google Scholar · View at Scopus
  128. P. Pérez-Martínez, A. García-Ríos, J. Delgado-Lista, F. Pérez-Jiménez, and J. López-Miranda, “Mediterranean diet rich in olive oil and obesity, metabolic syndrome and diabetes mellitus,” Current Pharmaceutical Design, vol. 17, no. 8, pp. 769–777, 2011. View at Publisher · View at Google Scholar · View at Scopus
  129. S.-T. Huang, J.-H. S. Pang, and R.-C. Yang, “Anti-cancer effects of Phyllanthus urinaria and relevant mechanisms,” Chang Gung Medical Journal, vol. 33, no. 5, pp. 477–487, 2010. View at Google Scholar · View at Scopus
  130. H. Poudyal, F. Campbell, and L. Brown, “Olive leaf extract attenuates cardiac, hepatic, and metabolic changes in high carbohydrate-, high fat-fed rats,” Journal of Nutrition, vol. 140, no. 5, pp. 946–953, 2010. View at Publisher · View at Google Scholar · View at Scopus
  131. K. Omagari, S. Kato, K. Tsuneyama et al., “Olive leaf extract prevents spontaneous occurrence of non-alcoholic steatohepatitis in SHR/NDmcr-cp rats,” Pathology, vol. 42, no. 1, pp. 66–72, 2010. View at Publisher · View at Google Scholar · View at Scopus
  132. G. C. Garg Munish, “Effect of phyllanthus urinaria in biochemical profile of experimental hyperglycemic albino rats,” Research Journal of Pharmaceutical Sciences, vol. 1, no. 1, pp. 2–6, 2012. View at Google Scholar
  133. B. Shen, J. Yu, S. Wang et al., “Phyllanthus urinaria ameliorates the severity of nutritional steatohepatitis both in vitro and in vivo,” Hepatology, vol. 47, no. 2, pp. 473–483, 2008. View at Publisher · View at Google Scholar · View at Scopus
  134. “Picrorhiza kurroa. Monograph,” Alternative Medicine Review, vol. 6, no. 3, pp. 319–321, 2001.
  135. K. L. Joy and R. Kuttan, “Anti-diabetic activity of Picrorrhiza kurroa extract,” Journal of Ethnopharmacology, vol. 67, no. 2, pp. 143–148, 1999. View at Publisher · View at Google Scholar · View at Scopus
  136. H.-S. Lee and S.-K. Ku, “Effect of Picrorrhiza rhizoma extracts on early diabetic nephropathy in streptozotocin-induced diabetic rats,” Journal of Medicinal Food, vol. 11, no. 2, pp. 294–301, 2008. View at Publisher · View at Google Scholar · View at Scopus
  137. H. S. Lee, C. B. Yoo, and S. K. Ku, “Hypolipemic effect of water extracts of Picrorrhiza kurroa in high fat diet treated mouse,” Fitoterapia, vol. 77, no. 7-8, pp. 579–584, 2006. View at Publisher · View at Google Scholar · View at Scopus
  138. G. M. Husain, P. N. Singh, and V. Kumar, “Antidiabetic activity of standardized extract of Picrorhiza kurroa in rat model of NIDDM,” Drug Discoveries & Therapeutics, vol. 3, no. 3, pp. 88–92, 2009. View at Google Scholar
  139. S. N. Shetty, S. Mengi, R. Vaidya, and A. D. B. Vaidya, “A study of standardized extracts of Picrorhiza kurroa Royle ex Benth in experimental nonalcoholic fatty liver disease,” Journal of Ayurveda and Integrative Medicine, vol. 1, no. 3, pp. 203–210, 2010. View at Publisher · View at Google Scholar · View at Scopus
  140. L.-K. Han, B.-J. Xu, Y. Kimura, Y.-N. Zheng, and H. Okuda, “Platycodi radix affects lipid metabolism in mice with high fat diet-induced obesity,” Journal of Nutrition, vol. 130, no. 11, pp. 2760–2764, 2000. View at Google Scholar · View at Scopus
  141. K.-S. Kim, E.-K. Seo, Y.-C. Lee et al., “Effect of dietary Platycodon grandiflorum on the improvement of insulin resistance in obese Zucker rats,” Journal of Nutritional Biochemistry, vol. 11, no. 9, pp. 420–424, 2000. View at Publisher · View at Google Scholar · View at Scopus
  142. J.-R. Noh, Y.-H. Kim, G.-T. Gang et al., “Preventative effects of Platycodon grandiflorum treatment on hepatic steatosis in high fat diet-fed C57BL/6 mice,” Biological and Pharmaceutical Bulletin, vol. 33, no. 3, pp. 450–454, 2010. View at Publisher · View at Google Scholar · View at Scopus
  143. J. Jurenka, “Therapeutic applications of pomegranate (Punica granatum L.): a review,” Alternative Medicine Review, vol. 13, no. 2, pp. 128–144, 2008. View at Google Scholar · View at Scopus
  144. J. Wang, X. Rong, I. S. I. Um, J. Yamahara, and Y. Li, “55-week treatment of mice with the Unani and Ayurvedic medicine pomegranate flower ameliorates ageing-associated insulin resistance and skin abnormalities,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 350125, 8 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  145. M. A. Jafri, M. Aslam, K. Javed, and S. Singh, “Effect of Punica granatum Linn. (flowers) on blood glucose level in normal and alloxan-induced diabetic rats,” Journal of Ethnopharmacology, vol. 70, no. 3, pp. 309–314, 2000. View at Publisher · View at Google Scholar · View at Scopus
  146. T. H. W. Huang, G. Peng, B. P. Kota et al., “Anti-diabetic action of Punica granatum flower extract: activation of PPAR-γ and identification of an active component,” Toxicology and Applied Pharmacology, vol. 207, no. 2, pp. 160–169, 2005. View at Publisher · View at Google Scholar · View at Scopus
  147. T. H.-W. Huang, G. Peng, B. P. Kota et al., “Pomegranate flower improves cardiac lipid metabolism in a diabetic rat model: role of lowering circulating lipids,” British Journal of Pharmacology, vol. 145, no. 6, pp. 767–774, 2005. View at Publisher · View at Google Scholar · View at Scopus
  148. Y. Li, S. Wen, B. P. Kota et al., “Punica granatum flower extract, a potent α-glucosidase inhibitor, improves postprandial hyperglycemia in Zucker diabetic fatty rats,” Journal of Ethnopharmacology, vol. 99, no. 2, pp. 239–244, 2005. View at Publisher · View at Google Scholar · View at Scopus
  149. P. Bagri, M. Ali, V. Aeri, M. Bhowmik, and S. Sultana, “Antidiabetic effect of Punica granatum flowers: effect on hyperlipidemia, pancreatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes,” Food and Chemical Toxicology, vol. 47, no. 1, pp. 50–54, 2009. View at Publisher · View at Google Scholar · View at Scopus
  150. K. Z.-Y. Xu, C. Zhu, M. S. Kim, J. Yamahara, and Y. Li, “Pomegranate flower ameliorates fatty liver in an animal model of type 2 diabetes and obesity,” Journal of Ethnopharmacology, vol. 123, no. 2, pp. 280–287, 2009. View at Publisher · View at Google Scholar · View at Scopus
  151. Y. Li, G. Peng, Q. Li et al., “Salacia oblonga improves cardiac fibrosis and inhibits postprandial hyperglycemia in obese zucker rats,” Life Sciences, vol. 75, no. 14, pp. 1735–1746, 2004. View at Publisher · View at Google Scholar · View at Scopus
  152. T. Hsun-Wei Huang, G. Peng, G. Qian Li, J. Yamahara, B. D. Roufogalis, and Y. Li, “Salacia oblonga root improves postprandial hyperlipidemia and hepatic steatosis in Zucker diabetic fatty rats: activation of PPAR-α,” Toxicology and Applied Pharmacology, vol. 210, no. 3, pp. 225–235, 2006. View at Publisher · View at Google Scholar · View at Scopus
  153. M. C. Thounaojam, R. N. Jadeja, R. V. Devkar, and A. V. Ramachandran, “Prevention of high fat diet induced insulin resistance in C57BL/6J mice by Sida rhomboidea ROXB. extract,” Journal of Health Science, vol. 56, no. 1, pp. 92–98, 2010. View at Publisher · View at Google Scholar · View at Scopus
  154. M. C. Thounaojam, R. N. Jadeja, U. V. Ramani, R. V. Devkar, and A. V. Ramachandran, “Sida rhomboidea. Roxb leaf extract down-regulates expression of PPARγ2 and leptin genes in high fat diet fed C57BL/6J mice and retards in vitro 3T3L1 pre-adipocyte differentiation,” International Journal of Molecular Sciences, vol. 12, no. 7, pp. 4661–4677, 2011. View at Publisher · View at Google Scholar · View at Scopus
  155. M. C. Thounaojam, R. N. Jadeja, S. P. Salunke, R. V. Devkar, and A. V. Ramachandran, “Sida rhomboidea.Roxb aqueous extract down-regulates in vivo expression of vascular cell adhesion molecules in atherogenic rats and inhibits in vitro macrophage differentiation and foam cell formation,” Immunopharmacology and Immunotoxicology, vol. 34, no. 5, pp. 832–843, 2012. View at Publisher · View at Google Scholar · View at Scopus
  156. M. C. Thounaojam, R. N. Jadeja, D. S. Dandekar, R. V. Devkar, and A. V. Ramachandran, “Sida rhomboidea.Roxb extract alleviates pathophysiological changes in experimental in vivo and in vitro models of high fat diet/fatty acid induced non-alcoholic steatohepatitis,” Experimental and Toxicologic Pathology, vol. 64, no. 3, pp. 217–224, 2012. View at Publisher · View at Google Scholar · View at Scopus
  157. Y. Haddad, D. Vallerand, A. Brault, and P. S. Haddad, “Antioxidant and hepatoprotective effects of silibinin in a rat model of nonalcoholic steatohepatitis,” Evidence-based Complementary and Alternative Medicine, vol. 2011, Article ID 647903, 10 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  158. G. Serviddio, F. Bellanti, A. M. Giudetti et al., “A silybin-phospholipid complex prevents mitochondrial dysfunction in a rodent model of nonalcoholic steatohepatitis,” Journal of Pharmacology and Experimental Therapeutics, vol. 332, no. 3, pp. 922–932, 2010. View at Publisher · View at Google Scholar · View at Scopus
  159. R. Amini, N. Nosrati, R. Yazdanparast, and M. Molaei, “Teucrium polium in prevention of steatohepatitis in rats,” Liver International, vol. 29, no. 8, pp. 1216–1221, 2009. View at Publisher · View at Google Scholar · View at Scopus
  160. R. Amini, R. Yazdanparast, S. Aghazadeh, and S. H. Ghaffari, “Teucrium polium reversed the MCD diet-induced liver injury in rats,” Human and Experimental Toxicology, vol. 30, no. 9, pp. 1303–1312, 2011. View at Publisher · View at Google Scholar · View at Scopus
  161. S. Aghazadeh and R. Yazdanparast, “Inhibition of JNK along with activation of ERK1/2 MAPK pathways improve steatohepatitis among the rats,” Clinical Nutrition, vol. 29, no. 3, pp. 381–385, 2010. View at Publisher · View at Google Scholar · View at Scopus
  162. I. Starakis, D. Siagris, L. Leonidou, E. Mazokopakis, A. Tsamandas, and C. Karatza, “Hepatitis caused by the herbal remedy Teucrium polium L,” European Journal of Gastroenterology and Hepatology, vol. 18, no. 6, pp. 681–683, 2006. View at Google Scholar · View at Scopus
  163. S. Savvidou, J. Goulis, I. Giavazis, K. Patsiaoura, P. Hytiroglou, and C. Arvanitakis, “Herb-induced hepatitis by Teucrium polium L.: report of two cases and review of the literature,” European Journal of Gastroenterology and Hepatology, vol. 19, no. 6, pp. 507–511, 2007. View at Publisher · View at Google Scholar · View at Scopus
  164. S. Chrubasik, M. H. Pittler, and B. D. Roufogalis, “Zingiberis rhizoma: a comprehensive review on the ginger effect and efficacy profiles,” Phytomedicine, vol. 12, no. 9, pp. 684–701, 2005. View at Publisher · View at Google Scholar · View at Scopus
  165. S. P. Akhani, S. L. Vishwakarma, and R. K. Goyal, “Anti-diabetic activity of Zingiber officinale in streptozotocin-induced type I diabetic rats,” Journal of Pharmacy and Pharmacology, vol. 56, no. 1, pp. 101–105, 2004. View at Publisher · View at Google Scholar · View at Scopus
  166. V. Sivakumar and S. Sivakumar, “Effect of an indigenous herbal compound preparation 'Trikatu' on the lipid profiles of atherogenic diet and standard diet fed Rattus norvegicus,” Phytotherapy Research, vol. 18, no. 12, pp. 976–981, 2004. View at Publisher · View at Google Scholar · View at Scopus
  167. N. Mascolo, R. Jain, S. C. Jain, and F. Capasso, “Ethnopharmacologic investigation of ginger (Zingiber officinale),” Journal of Ethnopharmacology, vol. 27, no. 1-2, pp. 129–140, 1989. View at Publisher · View at Google Scholar · View at Scopus
  168. A. Kar, B. K. Choudhary, and N. G. Bandyopadhyay, “Comparative evaluation of hypoglycaemic activity of some Indian medicinal plants in alloxan diabetic rats,” Journal of Ethnopharmacology, vol. 84, no. 1, pp. 105–108, 2003. View at Publisher · View at Google Scholar · View at Scopus
  169. Z. M. Al-Amin, M. Thomson, K. K. Al-Qattan, R. Peltonen-Shalaby, and M. Ali, “Anti-diabetic and hypolipidaemic properties of ginger (Zingiber officinale) in streptozotocin-induced diabetic rats,” British Journal of Nutrition, vol. 96, no. 4, pp. 660–666, 2006. View at Publisher · View at Google Scholar · View at Scopus
  170. R. K. Goyal and S. V. Kadnur, “Beneficial effects of Zingiber officinale on goldthioglucose induced obesity,” Fitoterapia, vol. 77, no. 3, pp. 160–163, 2006. View at Publisher · View at Google Scholar · View at Scopus
  171. L.-K. Han, X.-J. Gong, S. Kawano, M. Saito, Y. Kimura, and H. Okuda, “Antiobesity actions of Zingiber officinale Roscoe,” Yakugaku Zasshi, vol. 125, no. 2, pp. 213–217, 2005. View at Publisher · View at Google Scholar · View at Scopus
  172. S. Nammi, S. Sreemantula, and B. D. Roufogalis, “Protective effects of ethanolic extract of zingiber officinale rhizome on the development of metabolic syndrome in high-fat diet-fed rats,” Basic and Clinical Pharmacology and Toxicology, vol. 104, no. 5, pp. 366–373, 2009. View at Publisher · View at Google Scholar · View at Scopus
  173. S. Nammi, M. S. Kim, N. S. Gavande, G. Q. Li, and B. D. Roufogalis, “Regulation of low-density lipoprotein receptor and 3-hydroxy-3- methylglutaryl coenzyme A reductase expression by zingiber officinale in the liver of high-fat diet-fed rats,” Basic and Clinical Pharmacology and Toxicology, vol. 106, no. 5, pp. 389–395, 2010. View at Publisher · View at Google Scholar · View at Scopus
  174. X.-H. Li, K. C.-Y. McGrath, S. Nammi, A. K. Heather, and B. D. Roufogalis, “Attenuation of liver pro-inflammatory responses by zingiber officinale via inhibition of NF-kappa B activation in high-fat diet-fed rats,” Basic and Clinical Pharmacology and Toxicology, vol. 110, no. 3, pp. 238–244, 2012. View at Publisher · View at Google Scholar · View at Scopus
  175. H. Gao, T. Guan, C. Li et al., “Treatment with ginger ameliorates fructose-induced fatty liver and hypertriglyceridemia in rats: modulation of the hepatic carbohydrate response element-binding protein-mediated pathway,” Evidence-based Complementary and Alternative Medicine, vol. 2012, Article ID 570948, 12 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus