Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 683293, 6 pages
http://dx.doi.org/10.1155/2014/683293
Research Article

Treatment of Posttraumatic Stress Disorder Using the Traditional Japanese Herbal Medicine Saikokeishikankyoto: A Randomized, Observer-Blinded, Controlled Trial in Survivors of the Great East Japan Earthquake and Tsunami

1Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, No. 1-1, Seiryo-Machi, Aoba Ward, Sendai City 980-8574, Japan
2Department of Internal Medicine and Rehabilitation Science, Tohoku University Graduate School of Medicine, No. 1-1, Seiryo-Machi, Aoba Ward, Sendai City 980-8574, Japan
3Comprehensive Education Center for Community Medicine, Tohoku University Graduate School of Medicine, No. 2-1, Seiryo-Machi, Aoba Ward, Sendai City 980-8575, Japan
4Center for Traditional Asian Medicine, National Sendai-Nishitaga Hospital, No. 2-11-11, Kagitorihoncho, Taihaku Ward, Sendai City 982-8555, Japan
5Graduate Medical Education Center, Tohoku University Hospital, No. 1-1, Seiryo-Machi, Aoba Ward, Sendai City 980-8574, Japan
6Division of General Medicine, Saitama Medical Center, Jichi Medical University, No. 1-847, Amanumacho, Oomiya Ward, Saitama City 330-8503, Japan
7Department of Education and Support for Community Medicine, Tohoku University Hospital, No. 1-1, Seiryo-Machi, Aoba Ward, Sendai City 980-8574, Japan

Received 3 December 2013; Accepted 27 February 2014; Published 24 March 2014

Academic Editor: Pinar Atukeren

Copyright © 2014 Takehiro Numata et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. Nishi, Y. Koido, N. Nakaya et al., “Peritraumatic Distress, watching television, and posttraumatic stress symptoms among rescue workers after the Great Japan earthquake,” PLOS ONE, vol. 7, no. 4, 2012. View at Google Scholar
  2. X.-Z. Meng, F. Wu, P.-K. Wei et al., “A Chinese herbal formula to improve general psychological status in posttraumatic stress disorder: a randomized placebo-controlled trial on Sichuan earthquake survivors,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 691258, 11 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. T. Takeda, M. Tadakawa, S. Koga et al., “Premenstrual symptoms and posttraumatic stress disorder in Japanese high school students 9 months after the Great East Japan Earthquake,” The Tohoku Journal of Experimental Medicine, vol. 230, no. 3, pp. 151–154, 2013. View at Google Scholar
  4. K. Iwasaki, T. Satoh-Nakagawa, M. Maruyama et al., “A randomized, observer-blind, controlled trial of the traditional Chinese medicine Yi-Gan San for improvement of behavioral and psychological symptoms and activities of daily living in dementia patients,” Journal of Clinical Psychiatry, vol. 66, no. 2, pp. 248–252, 2005. View at Google Scholar · View at Scopus
  5. T. C. Neylan, C. R. Marmar, T. J. Metzler et al., “Sleep disturbances in the Vietnam generation: findings from a nationally representative sample of male Vietnam Veterans,” American Journal of Psychiatry, vol. 155, no. 7, pp. 929–933, 1998. View at Google Scholar · View at Scopus
  6. H. D. Chilcoat and N. Breslau, “Posttraumatic stress disorder and drug disorders: testing causal pathways,” Archives of General Psychiatry, vol. 55, no. 10, pp. 913–917, 1998. View at Publisher · View at Google Scholar · View at Scopus
  7. F. Oosthuizen, G. Wegener, and B. H. Harvey, “Nitric oxide as inflammatory mediator in post-traumatic stress disorder (PTSD): evidence from an animal model,” Neuropsychiatric Disease and Treatment, vol. 1, no. 2, pp. 109–123, 2005. View at Publisher · View at Google Scholar
  8. T. Itoh, S. Michijiri, S. Murai et al., “Effects of Chaihu-Guizhi-Ganjiang-Tang on the levels of monoamines and their related substances, and acetylcholine in discrete brain regions of mice,” American Journal of Chinese Medicine, vol. 24, no. 1, pp. 53–64, 1996. View at Google Scholar · View at Scopus
  9. T. Ushiroyama, A. Ikeda, K. Sakuma, and M. Ueki, “Chai-hu-gui-zhi-gan-jiang-tang regulates plasma interleukin-6 and soluble interleukin-6 receptor concentrations and improves depressed mood in climacteric women with insomnia,” American Journal of Chinese Medicine, vol. 33, no. 5, pp. 703–711, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. K. Takeshita, Y. Saisho, K. Kitamura et al., “Pneumonitis induced by ou-gon (scullcap),” Internal Medicine, vol. 40, no. 8, pp. 764–768, 2001. View at Google Scholar · View at Scopus
  11. K. Iwasaki, K. Kosaka, H. Mori et al., “Open label trial to evaluate the efficacy and safety of yokukansan, A traditional Asian medicine, in dementia with Lewy bodies,” Journal of the American Geriatrics Society, vol. 59, no. 5, pp. 936–938, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. S. Takayama, T. Kamiya, M. Watanabe et al., “Report on disaster medical operations with acupuncture/massage therapy after the great East Japan earthquake,” Integrative Medicine Insights, vol. 7, pp. 1–5, 2012. View at Google Scholar
  13. S. Takayama, R. Okitsu, K. Iwasaki et al., “The role of oriental medicine in the great East Japan Earthquake disaster,” Kampo Medicine, vol. 62, no. 5, pp. 621–626, 2011 (Japanese). View at Publisher · View at Google Scholar
  14. S. Takayama, R. Okitsu, K. Iwasaki et al., “Role of oriental medicine in the great East Japan earthquake,” German Journal of Acupuncture and Related Tequniques, vol. 55, no. 2, 2012 (German). View at Google Scholar