Evidence-Based Complementary and Alternative Medicine

Research Article

Acute and Long-Term Toxicity of Mango Leaves Extract in Mice and Rats

Table 4

The effects on hematology and coagulation function of MLE in SD rats (, g).


Sex	Parameters	Control group	Low dose group	Medium dose group	High dose group

♂	WBC (×10⁹/L)	10.08 ± 1.29	12.47 ± 3.03	11.66 ± 2.32	11.58 ± 3.36
	Neut (%)	12.06 ± 1.38	15.48 ± 4.58	12.33 ± 2.89	12.30 ± 5.21
	Lymph (%)	83.32 ± 1.64	79.10 ± 4.80	81.78 ± 3.14	81.85 ± 5.50
	Mono (%)	2.58 ± 0.64	3.02 ± 0.66	2.95 ± 0.71	3.00 ± 0.87
	Eos (%)	1.24 ± 0.33	1.10 ± 0.18	1.33 ± 0.56	1.65 ± 0.32
	RBC (×10¹²/L)	9.24 ± 0.36	9.52 ± 0.59	9.57 ± 0.36	9.79 ± 0.34*
	HGB (g/L)	167.40 ± 6.80	166.17 ± 9.33	162.33 ± 4.27	167.50 ± 3.15
	HCT (%)	48.32 ± 1.57	48.40 ± 3.48	48.00 ± 1.08	49.87 ± 1.64
	MCV (fL)	52.28 ± 0.55	50.82 ± 0.77**	50.20 ± 1.44*	50.98 ± 2.29
	MCH (pg)	18.16 ± 1.10	17.50 ± 0.67	16.98 ± 0.57*	17.13 ± 0.72
	MCHC (g/L)	347.20 ± 20.66	344.50 ± 13.40	338.33 ± 3.33	336.67 ± 5.99
	PLT (×10⁹/L)	1145.00 ± 121.6	1208.00 ± 158.73	1216.17 ± 98.95	1217.00 ± 104.08
	Retic ()	2.96 ± 0.42	2.80 ± 0.43	2.96 ± 0.36	2.56 ± 0.40
	PT (s)	16.04 ± 1.13	16.48 ± 2.71	15.68 ± 0.93	16.15 ± 1.22

♀	WBC (×10⁹/L)	5.10 ± 1.44	5.97 ± 0.89	5.77 ± 1.01	5.45 ± 1.41
	Neut (%)	15.92 ± 2.58	15.62 ± 3.79	17.77 ± 2.32	16.38 ± 5.62
	Lymph (%)	78.27 ± 2.64	78.38 ± 4.06	76.48 ± 2.70	78.08 ± 7.14
	Mono (%)	2.57 ± 0.46	3.02 ± 0.58	2.95 ± 1.11	2.73 ± 1.18
	Eos (%)	2.00 ± 0.40	1.60 ± 0.67	1.73 ± 0.29	1.97 ± 0.58
	RBC (×10¹²/L)	8.63 ± 0.23	8.81 ± 0.56	8.55 ± 0.26	8.64 ± 0.48
	HGB (g/L)	159.17 ± 2.93	158.50 ± 7.34	157.50 ± 2.88	159.17 ± 6.55
	HCT (%)	46.53 ± 1.29	46.52 ± 2.61	46.28 ± 1.16	46.45 ± 2.14
	MCV (fL)	53.92 ± 1.66	52.83 ± 1.26	54.18 ± 1.70	53.78 ± 0.95
	MCH (pg)	18.43 ± 0.46	18.05 ± 0.63	18.43 ± 0.37	18.47 ± 0.32
	MCHC (g/L)	342.17 ± 5.78	341.33 ± 5.79	340.50 ± 6.06	343.50 ± 2.88
	PLT (×10⁹/L)	1134.67 ± 63.64	1268.33 ± 182.79	1211.17 ± 121.14	1197.83 ± 73.19
	Retic ()	2.86 ± 0.71	2.45 ± 0.63	2.79 ± 0.37	2.57 ± 0.57
	PT (s)	16.52 ± 0.82	16.00 ± 1.20	16.27 ± 0.63	16.57 ± 1.29

*Means ; **means ; means the number of animals.