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Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 703624, 8 pages
http://dx.doi.org/10.1155/2014/703624
Research Article

Protein Fractions from Korean Mistletoe (Viscum Album coloratum) Extract Induce Insulin Secretion from Pancreatic Beta Cells

1School of Life Sciences, Handong Global University, Pohang, Gyungbuk 791-708, Republic of Korea
2Department of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
3Department of Biological Chemistry, The Weizmann Institute of Science, 76100 Rehovot, Israel

Received 23 February 2014; Accepted 22 April 2014; Published 14 May 2014

Academic Editor: Cicero L. T. Chang

Copyright © 2014 Ki-Wook Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Mistletoe (Viscum Album coloratum) has been known as a medicinal plant in European and Asian countries. Recent data show that biological activity of mistletoe alleviates hypertension, heart disease, renal failure, and cancer development. In this study, we report the antidiabetic effect of Korean mistletoe extract (KME). KME treatments enhanced the insulin secretion from the pancreatic β-cell without any effects of cytotoxicity. PDX-1 and beta2/neuroD known as transcription factors that regulate the expression of insulin gene were upregulated by treatment of the KME protein fractions isolated by ion-exchange chromatography after ammonium sulfate precipitation. Furthermore, these KME protein fractions significantly lowered the blood glucose level and the volume of drinking water in alloxan induced hyperglycemic mice. Taken together with the findings, it provides new insight that KME might be served as a useful source for the development of medicinal reagent to reduce blood glucose level of type I diabetic patients.