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Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 704507, 5 pages
Research Article

Specificity Study on Concentration of Monoamine Transmitters at Acupoint and Effect of Acupuncture on Its Distribution

College of Acupuncture and Moxibustion, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China

Received 5 August 2014; Accepted 15 September 2014; Published 2 December 2014

Academic Editor: Zhang Weibo

Copyright © 2014 Ting Luo and Yi Guo. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


To investigate the distribution of monoamine transmitters at acupoints and effect of acupuncture on it. Take this experiment by means of microdialysis. Twenty rabbits were randomly assigned to two groups (Group A: acupuncture Guanyuan (RN4), Group B: acupuncture nonacupoint which is besides Guanyuan (RN4) 1 cm). Before and after acupuncture was taken, tissue fluids both at Zhongwan (RN12) which is on the same meridian as Guanyuan and at a nonacupoint 1 cm away from Zhongwan were collected through microdialysis, respectively. The collected samples were analyzed to determine concentrations of monoamine transmitters. Epinephrine and 5-HT were detected. An unknown substance was found. Its concentration at acupoint was significantly higher than that at nonacupoint and decreased after acupuncture. Its significant specificity at acupoints suggests that it may play an important role in meridian’s activity.