New Treatment for Alzheimer’s Disease, Kamikihito, Reverses Amyloid--Induced Progression of Tau Phosphorylation and Axonal Atrophy
Figure 4
KKT enhances PP2A activity in vitro and in vivo. (a) Cortical neurons were cultured for 3 d and then treated with vehicle solution or KKT (10 μg/mL). At 1 h after each treatment, the cells were treated with A (25–35) (10 μM) for 72 h. The cell lysates were prepared for the PP2A activity assay. PP2A activity was measured using a serine/threonine phosphatase assay system. (b) Vehicle solution or KKT (500 mg/kg/day) was administered once a day for 15 days to wild-type or 5XFAD mice. Cerebral cortex homogenates were used for the PP2A activity assay. versus Veh (, One-way ANOVA, post hoc Dunnett’s test).
