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Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 717686, 7 pages
http://dx.doi.org/10.1155/2014/717686
Research Article

Effect of Isopropanolic Cimicifuga racemosa Extract on Uterine Fibroids in Comparison with Tibolone among Patients of a Recent Randomized, Double Blind, Parallel-Controlled Study in Chinese Women with Menopausal Symptoms

1Department of Gynecology, The First Hospital of Peking University, Beijing, China
2Departments of Life Sciences, Technical University of Braunschweig, 38106 Braunschweig, Germany
3Department of Gynecology, Jiangsu Province People’s Hospital, Nanjing, China
4Department of Gynecology, The General Hospital of PLA, Beijing, China
5Department of Gynecology, The Third Hospital of Peking University, Beijing, China
6Department of Gynecology, West China Second Hospital of Sichuan University, Chengdu, China
7Biometrical Department, Excel Pharma Studies, Beijing, China
8Schaper & Brümmer GmbH & Co. KG, Preclinical and Clinical Research, 38259 Salzgitter, Germany

Received 19 April 2013; Revised 11 January 2014; Accepted 15 January 2014; Published 2 March 2014

Academic Editor: José Luis Ríos

Copyright © 2014 Sisi Xi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. Effect of isopropanolic Cimicifuga racemosa extract (iCR) on uterine fibroid size compared with tibolone. Method. The randomized, double-blind, controlled study in China enrolled 244 patients aged 40–60 years with menopausal symptoms (Kupperman Menopause Index ≥ 15). The participants were treated with either iCR of 40 mg crude drug/day () or tibolone 2.5 mg/day () orally for 3 months in 2004. Now, we investigated the subset of all women () with at least one uterine fibroid at onset of treatment for the effect of iCR (N = 34) on fibroid size compared with tibolone () by transvaginal ultrasonography. Results. The median myoma volume decreased upon iCR by as much as −30% () but increased upon tibolone by . The percentage of volume change, mean diameter change and geometric mean diameter change of the iCR group compared to tibolone were statistically significant (, 0.021, 0.016 respectively). Conclusion. Our results suggest that iCR (Remifemin) is a valid herbal medicinal product in patients with uterine myomas as it provides adequate relief from menopausal symptoms and inhibits growth of the myomas in contrast to tibolone.