Coadministration of <i>Pinellia ternata</i> Can Significantly Reduce <i>Aconitum carmichaelii</i> to Inhibit CYP3A Activity in Rats

<div>CYP3A protein (a), CYP3A1 mRNA (b), and CYP3A2 mRNA (c) expression levels in rat livers. Before the rat livers were prepared, rats were pretreated with the studied drugs or saline once daily for 7 d. The rats were pretreated with SKF-525A hydrochloride (0.1 g<svg height="4.3561pt" id="M244" style="vertical-align:-0.04981995pt" version="1.1" viewbox="-0.0498162 -4.30628 3.20019 4.3561" width="3.20019pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0135,0,0,-0.0135,0,0)"><path d="M170 255C170 288 146 313 114 313S58 288 58 255C58 221 82 198 114 198S170 221 170 255Z" id="g113-46"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="228" vert-adv-y="228"></glyph.data></g></svg>kg<sup>−1</sup>, 7 d, p.o.) as the positive control (PC) for CYP3A inhibition. <svg height="14.4438pt" id="M245" style="vertical-align:-3.9935pt" version="1.1" viewbox="-0.0498162 -10.4503 53.3164 14.4438" width="53.3164pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0095,0,0,-0.0095,0,-5.984)"><path d="M499 152C501 180 492 209 480 228C432 233 403 235 357 256C403 278 432 279 480 284C492 303 504 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Data are expressed as mean <svg height="7.66065pt" id="M249" style="vertical-align:-0.3625798pt" version="1.1" viewbox="-0.0498162 -7.29807 8.08224 7.66065" width="8.08224pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0135,0,0,-0.0135,0,0)"><path d="M535 290V340H323V533H265V340H52V290H265V84H323V290H535ZM535 -22V28H52V-22H535Z" id="g117-37"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="587" vert-adv-y="587"></glyph.data></g></svg> SD.</div>

Evidence-Based Complementary and Alternative Medicine

fig4

Figure 4

Figure 4: Coadministration of <i>Pinellia ternata</i> Can Significantly Reduce <i>Aconitum carmichaelii</i> to Inhibit CYP3A Activity in Rats 

Evidence-Based Complementary and Alternative Medicine

Coadministration of Pinellia ternata Can Significantly Reduce Aconitum carmichaelii to Inhibit CYP3A Activity in Rats

Figure 4